Tan Lab | DSigDB

Gene Set: D4 : TTD - 3-Beta-Hydroxy-5-Androsten-17-One

Collection

D4 : TTD

Chemical Name

3-Beta-Hydroxy-5-Androsten-17-One ( From PubChem : PRASTERONE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
288.424 g/mol	1	2	3.8792	True

Structure

InChI

InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3

InChIKey

Links

Gene (8 / 22)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			HSD17B1		Research target
TTD	Inhibitor			HSD3B1		Successful target
TTD	Inhibitor			HSD3B2		Successful target
PubChem	Ratio Potency (uM)	uM	17.593	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	34.670	AR	-	GI(Protien) :
PubChem	AR Potency (uM)	uM	48.558	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	54.483	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	54.538	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.194	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.344	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.376	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.389	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.617	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.674	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.776	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	1.096	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	1.451	ESR1	-	GI(Protien) :
PubChem	None	uM		NR1H4	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	43.647	NR3C1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	43.679	NR3C1	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :
ChEMBL	Potency	nM	15848.900	CYP3A4	-	Target : CHEMBL340

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