Tan Lab | DSigDB

Gene Set: D4 : TTD - PIPERINE

Collection

D4 : TTD

Chemical Name

PIPERINE ( From PubChem : PIPERINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Approved	Not	Not	Approved	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
285.338 g/mol	0	4	2.9351	True

Structure

InChI

InChI=1S/C17H19NO3/c19-17(18-10-4-1-5-11-18)7-3-2-6-14-8-9-15-16(12-14)21-13-20-15/h2-3,6-9,12H,1,4-5,10-11,13H2/b6-2+,7-3+

InChIKey

Links

Gene (18 / 29)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			MAOA		Successful target
TTD	Inhibitor			MAOB		Successful target
PubChem	None	uM		ABCB1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.613	AHR	-	GI(Protien) :
PubChem	AhR Potency (uM)	uM	1.794	AHR	-	GI(Protien) :
PubChem	AhR Potency (uM)	uM	2.169	AHR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	2.169	AHR	-	GI(Protien) :
PubChem	Potency	uM	14.125	AHR	-	GI(Protien) :
PubChem	Potency	uM	11.577	ATAD5	-	GI(Protien) :
PubChem	Potency	uM	8.912	BRCA1	-	GI(Protien) :
PubChem	Potency	uM	12.589	CYP3A4	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	1.371	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	3.857	ESR1	-	GI(Protien) :
PubChem	Potency	uM	15.849	HPGD	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	17.903	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	2.512	NPC1	-	GI(Protien) :
PubChem	None	uM		NR0B1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	54.948	NR1H4	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	28.184	NR1I2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	43.743	PPARG	-	GI(Protien) :
PubChem	None	uM		PPARG	-	GI(Protien) :
PubChem	Potency	uM	2.512	RAB9A	-	GI(Protien) :
PubChem	Potency	uM	14.125	SMN2	-	GI(Protien) :
ChEMBL	Potency	nM	11577.400	ATAD5	-	Target : CHEMBL1741209
ChEMBL	Potency	nM	12589.300	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	15848.900	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	2511.900	NPC1	-	Target : CHEMBL1293277
ChEMBL	Potency	nM	2511.900	RAB9A	-	Target : CHEMBL1293294
ChEMBL	Potency	nM	14125.400	SMN1; SMN2	-	Target : CHEMBL1293232

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