Tan Lab | DSigDB

Gene Set: D4 : TTD - Pazopanib

Collection

D4 : TTD

Chemical Name

Pazopanib ( From PubChem : PAZOPANIB )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
437.518 g/mol	2	7	4.9931	True

Structure

InChI

InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25)

InChIKey

CUIHSIWYWATEQL-UHFFFAOYSA-N

Links

Gene (13 / 27)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Multitarget			KDR		Successful target
TTD	Inhibitor			KDR		Successful target
TTD	Drug(s)			KDR		Successful target
TTD	Multitarget			KIT		Successful target
TTD	Inhibitor			KIT		Successful target
TTD	Drug(s)			KIT		Successful target
PubChem	AhR Potency (uM)	uM		AHR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	11.883	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	18.281	AR	-	GI(Protien) :
PubChem	None	uM	7.900	CSF1R	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	13.448	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	16.930	ESR1	-	GI(Protien) :
PubChem	None	uM	2.300	KIT	-	GI(Protien) :
PubChem	None	uM	2.800	KIT	-	GI(Protien) :
PubChem	None	uM	6.500	KIT	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	29.847	NR1H4	-	GI(Protien) :
PubChem	None	uM		NR1H4	-	GI(Protien) :
PubChem	None	uM	4.900	PDGFRA	-	GI(Protien) :
PubChem	None	uM	2.000	PDGFRB	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	29.847	PPARD	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	26.601	PPARG	-	GI(Protien) :
PubChem	None	uM		PPARG	-	GI(Protien) :
PubChem	Potency	uM	10.593	TDP1	-	GI(Protien) :
PubChem	Potency	uM	13.336	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.307	YES1		GI(Protien) :
ChEMBL	Inhibition	-		KDR	-	Target : CHEMBL279
ChEMBL	Inhibition	-		KDR	-	Target : CHEMBL279

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