Tan Lab | DSigDB

Gene Set: D4 : CTD - ipriflavone

Collection

D4 : CTD

Chemical Name

ipriflavone ( From PubChem : IPRIFLAVONE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Approved	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
280.318 g/mol	0	3	4.2472	True

Structure

InChI

InChI=1S/C18H16O3/c1-12(2)21-14-8-9-15-17(10-14)20-11-16(18(15)19)13-6-4-3-5-7-13/h3-12H,1-2H3

InChIKey

SFBODOKJTYAUCM-UHFFFAOYSA-N

Links

Gene (26 / 54)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(binding)			ESR1		C018986
CTD	increases(activity)			ESR1		C018986
CTD	affects(binding)			ESR2		C018986
CTD	increases(activity)			ESR2		C018986
PubChem	AhR Potency (uM)	uM	1.585	AHR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	2.113	AHR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	4.731	AHR	-	GI(Protien) :
PubChem	AhR Potency (uM)	uM	11.436	AHR	-	GI(Protien) :
PubChem	None	uM		APP	-	GI(Protien) :
PubChem	Potency	uM	9.200	ATAD5	-	GI(Protien) :
PubChem	None	uM		CASP1	-	GI(Protien) :
PubChem	IC50_Mean	uM	19.700	CASP3	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.422	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.531	ESR1	-	GI(Protien) :
PubChem	Potency	uM	1.585	HTT	-	GI(Protien) :
PubChem	Potency	uM	17.783	MAPK1	-	GI(Protien) :
PubChem	None	uM		MCL1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	21.957	NFE2L2	-	GI(Protien) :
PubChem	None	uM		NFKB1	-	GI(Protien) :
PubChem	None	uM		NLRP1	-	GI(Protien) :
PubChem	None	uM		NLRP3	-	GI(Protien) :
PubChem	None	uM		NLRP3	-	GI(Protien) :
PubChem	Potency	uM	0.501	NPC1	-	GI(Protien) :
PubChem	Potency	uM	0.794	NPC1	-	GI(Protien) :
PubChem	None	uM		NR0B1	-	GI(Protien) :
PubChem	Potency	uM	0.447	RAB9A	-	GI(Protien) :
PubChem	Potency	uM	0.891	RAB9A	-	GI(Protien) :
PubChem	None	uM		RELA	-	GI(Protien) :
PubChem	IC50_Mean	uM	57.200	SENP6	-	GI(Protien) :
PubChem	None	uM		SENP6	-	GI(Protien) :
PubChem	IC50_Mean	uM	5.350	SENP7	-	GI(Protien) :
PubChem	None	uM		SENP7	-	GI(Protien) :
PubChem	None	uM		SENP7	-	GI(Protien) :
PubChem	IC50_Mean	uM	94.800	SENP8	-	GI(Protien) :
PubChem	None	uM		SENP8	-	GI(Protien) :
PubChem	None	uM		SLC12A5	-	GI(Protien) :
PubChem	None	uM		SLC12A5	-	GI(Protien) :
PubChem	Potency	uM	3.162	SMN2	-	GI(Protien) :
PubChem	EC50	uM	0.418	STAT1	-	GI(Protien) :
PubChem	None	uM		STAT1	-	GI(Protien) :
PubChem	None	uM		STAT1	-	GI(Protien) :
PubChem	Potency	uM	18.356	TDP1	-	GI(Protien) :
ChEMBL	Potency	nM	9200.000	ATAD5	-	Target : CHEMBL1741209
ChEMBL	Potency	nM	1584.900	HTT	-	Target : CHEMBL5514
ChEMBL	Potency	nM	17782.800	MAPK1	-	Target : CHEMBL4040
ChEMBL	Potency	nM	794.300	NPC1	-	Target : CHEMBL1293277
ChEMBL	Potency	nM	501.200	NPC1	-	Target : CHEMBL1293277
ChEMBL	Potency	nM	446.700	RAB9A	-	Target : CHEMBL1293294
ChEMBL	Potency	nM	891.300	RAB9A	-	Target : CHEMBL1293294
ChEMBL	IC50	nM	57200.000	SENP6	-	Target : CHEMBL1741215
ChEMBL	IC50	nM	5350.000	SENP7	-	Target : CHEMBL1741213
ChEMBL	IC50	nM	94800.000	SENP8	-	Target : CHEMBL1741207
ChEMBL	Potency	nM	3162.300	SMN1; SMN2	-	Target : CHEMBL1293232
ChEMBL	EC50	nM	418.000	STAT1	-	Target : CHEMBL6101

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