Tan Lab | DSigDB

Gene Set: D4 : CTD - fisetin

Collection

D4 : CTD

Chemical Name

fisetin ( From PubChem : FISETIN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
286.236 g/mol	4	6	2.2824	True

Structure

InChI

InChI=1S/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H

InChIKey

XHEFDIBZLJXQHF-UHFFFAOYSA-N

Links

Gene (56 / 139)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(reaction)			AR		C017875
CTD	increases(expression)			AR		C017875
CTD	increases(folding)			AR		C017875
CTD	increases(stability)			AR		C017875
CTD	decreases(expression)			AR		C017875
CTD	decreases(stability)			AR		C017875
CTD	affects(cotreatment)			BAK1		C017875
CTD	increases(expression)			BAK1		C017875
CTD	affects(cotreatment)			BID		C017875
CTD	increases(cleavage)			BID		C017875
CTD	affects(cotreatment)			BIRC5		C017875
CTD	decreases(expression)			BIRC5		C017875
CTD	decreases(reaction)			CASP3		C017875
CTD	increases(activity)			CASP3		C017875
CTD	affects(cotreatment)			CASP3		C017875
CTD	increases(activity)			CASP3		C017875
CTD	increases(cleavage)			CASP3		C017875
CTD	decreases(reaction)			CASP3		C017875
CTD	increases(expression)			CASP3		C017875
CTD	affects(cotreatment)			CASP7		C017875
CTD	increases(cleavage)			CASP7		C017875
CTD	increases(reaction)			CASP7		C017875
CTD	decreases(reaction)			CASP8		C017875
CTD	increases(activity)			CASP8		C017875
CTD	affects(cotreatment)			CASP8		C017875
CTD	increases(activity)			CASP8		C017875
CTD	increases(cleavage)			CASP8		C017875
CTD	affects(cotreatment)			CASP9		C017875
CTD	increases(cleavage)			CASP9		C017875
CTD	increases(reaction)			CASP9		C017875
CTD	increases(activity)			CASP9		C017875
CTD	affects(cotreatment)			CCNB1		C017875
CTD	decreases(expression)			CCNB1		C017875
CTD	affects(cotreatment)			CD40		C017875
CTD	decreases(reaction)			CD40		C017875
CTD	increases(expression)			CD40		C017875
CTD	affects(cotreatment)			CDKN1A		C017875
CTD	increases(expression)			CDKN1A		C017875
CTD	affects(cotreatment)			COMT		C017875
CTD	decreases(activity)			COMT		C017875
CTD	decreases(reaction)			CXCL8		C017875
CTD	increases(secretion)			CXCL8		C017875
CTD	decreases(reaction)			CXCL8		C017875
CTD	increases(expression)			CXCL8		C017875
CTD	affects(cotreatment)			CXCL8		C017875
CTD	decreases(reaction)			CXCL8		C017875
CTD	increases(expression)			CXCL8		C017875
CTD	increases(secretion)			CXCL8		C017875
CTD	increases(activity)			DIO2		C017875
CTD	affects(cotreatment)			DNMT1		C017875
CTD	decreases(activity)			DNMT1		C017875
CTD	affects(cotreatment)			FASLG		C017875
CTD	increases(expression)			FASLG		C017875
CTD	increases(expression)			HMOX1		C017875
CTD	affects(cotreatment)			IL13		C017875
CTD	decreases(reaction)			IL13		C017875
CTD	increases(expression)			IL13		C017875
CTD	affects(cotreatment)			IL1B		C017875
CTD	decreases(reaction)			IL1B		C017875
CTD	increases(expression)			IL1B		C017875
CTD	increases(secretion)			IL1B		C017875
CTD	affects(cotreatment)			IL4		C017875
CTD	decreases(reaction)			IL4		C017875
CTD	increases(expression)			IL4		C017875
CTD	decreases(expression)			IL4		C017875
CTD	affects(cotreatment)			IL5		C017875
CTD	decreases(reaction)			IL5		C017875
CTD	increases(expression)			IL5		C017875
CTD	decreases(reaction)			IL6		C017875
CTD	increases(expression)			IL6		C017875
CTD	affects(cotreatment)			IL6		C017875
CTD	decreases(reaction)			IL6		C017875
CTD	increases(expression)			IL6		C017875
CTD	increases(secretion)			IL6		C017875
CTD	decreases(reaction)			KLK3		C017875
CTD	increases(expression)			KLK3		C017875
CTD	decreases(expression)			KLK3		C017875
CTD	decreases(secretion)			KLK3		C017875
CTD	increases(phosphorylation)			MAPK1		C017875
CTD	increases(phosphorylation)			MAPK3		C017875
CTD	decreases(reaction)			MMP9		C017875
CTD	increases(expression)			MMP9		C017875
CTD	decreases(reaction)			NFATC2		C017875
CTD	increases(activity)			NFATC2		C017875
CTD	increases(expression)			NFE2L2		C017875
CTD	decreases(activity)			PARP1		C017875
CTD	affects(cotreatment)			RELA		C017875
CTD	affects(localization)			RELA		C017875
CTD	decreases(reaction)			RELA		C017875
CTD	increases(activity)			RELA		C017875
CTD	increases(expression)			SREBF2		C017875
CTD	affects(cotreatment)			TNF		C017875
CTD	decreases(reaction)			TNF		C017875
CTD	increases(expression)			TNF		C017875
CTD	increases(secretion)			TNF		C017875
CTD	affects(cotreatment)			TP53		C017875
CTD	affects(localization)			TP53		C017875
CTD	increases(expression)			TP53		C017875
CTD	increases(phosphorylation)			TP53		C017875
CTD	decreases(reaction)			TP53		C017875
CTD	increases(expression)			TP53		C017875
CTD	decreases(reaction)			TP53		C017875
CTD	increases(glucuronidation)			UGT1A1		C017875
CTD	increases(glucuronidation)			UGT1A10		C017875
CTD	increases(glucuronidation)			UGT1A7		C017875
CTD	increases(glucuronidation)			UGT1A8		C017875
CTD	increases(glucuronidation)			UGT1A9		C017875
PubChem	Potency	uM	15.849	ALOX12	-	GI(Protien) :
PubChem	Potency	uM	1.995	ALOX15	-	GI(Protien) :
PubChem	Potency	uM	5.012	ALOX15	-	GI(Protien) :
PubChem	None	uM		CSNK1G2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	19.953	CYP2C9	-	GI(Protien) :
PubChem	Potency	uM	39.811	CYP3A4	-	GI(Protien) :
PubChem	None	uM		MAP3K5	-	GI(Protien) :
PubChem	Potency	uM	12.589	MAPK1	-	GI(Protien) :
PubChem	Potency	uM	5.012	MAPT	-	GI(Protien) :
PubChem	None	uM		PIM2	-	GI(Protien) :
PubChem	Potency	uM	0.398	POLK	-	GI(Protien) :
PubChem	Potency	uM	0.562	POLK	-	GI(Protien) :
PubChem	None	uM		STK16	-	GI(Protien) :
PubChem	Potency	uM	5.957	TDP1	-	GI(Protien) :
PubChem	Potency	uM	6.684	TDP1	-	GI(Protien) :
ChEMBL	Potency	nM	15848.900	ALOX12	-	Target : CHEMBL3687
ChEMBL	Potency	nM	1995.300	ALOX15	-	Target : CHEMBL2903
ChEMBL	Potency	nM	5011.900	ALOX15	-	Target : CHEMBL2903
ChEMBL	Activity	-		ALOX15	-	Target : CHEMBL2903
ChEMBL	Potency	nM	891.300	APEX1	-	Target : CHEMBL5619
ChEMBL	Potency	nM	19952.600	CYP2C9	-	Target : CHEMBL3397
ChEMBL	Potency	nM	39810.700	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	31622.800	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	1258.900	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	2511.900	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	14125.400	KDM4E	-	Target : CHEMBL1293226
ChEMBL	Potency	nM	12589.300	MAPK1	-	Target : CHEMBL4040
ChEMBL	Potency	nM	5011.900	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	3162.300	RECQL	-	Target : CHEMBL1293236
ChEMBL	Activity	-		TOP1	-	Target : CHEMBL1781
ChEMBL	Activity	-		TOP2A	-	Target : CHEMBL1806

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