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Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : CTD - mono-(2-ethylhexyl)phthalate

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Collection	D4 : CTD
Chemical Name	mono-(2-ethylhexyl)phthalate ( From PubChem : MEHP )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Not Not Not Not Not Not Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 278.343 g/mol 1 4 3.758 True
Structure
InChI	InChI=1S/C16H22O4/c1-3-5-8-12(4-2)11-20-16(19)14-10-7-6-9-13(14)15(17)18/h6-7,9-10,12H,3-5,8,11H2,1-2H3,(H,17,18)/t12-/m1/s1
InChIKey	DJDSLBVSSOQSLW-GFCCVEGCSA-N
Links
Gene (68 / 122) ⊖ Less	Source Type Unit Value Gene PMID Assay Other CTD decreases(expression) AMH C016599 CTD increases(expression) AOX1 C016599 CTD increases(expression) ARRDC3 C016599 CTD increases(expression) BAX C016599 CTD decreases(expression) BCL2 C016599 CTD decreases(reaction) CASP3 C016599 CTD increases(activity) CASP3 C016599 CTD increases(reaction) CASP3 C016599 CTD increases(activity) CASP3 C016599 CTD increases(expression) CASP3 C016599 CTD increases(activity) CASP7 C016599 CTD increases(activity) CDKN1A C016599 CTD decreases(reaction) CDKN1A C016599 CTD decreases(activity) CELSR2 C016599 CTD decreases(reaction) CELSR2 C016599 CTD increases(phosphorylation) CELSR2 C016599 CTD decreases(reaction) CGA C016599 CTD increases(abundance) CGA C016599 CTD decreases(reaction) CGB C016599 CTD increases(abundance) CGB C016599 CTD increases(expression) CLDN6 C016599 CTD decreases(activity) CSNK1A1 C016599 CTD decreases(reaction) CSNK1A1 C016599 CTD increases(phosphorylation) CSNK1A1 C016599 CTD increases(expression) CTNNB1 C016599 CTD decreases(reaction) CYP19A1 C016599 CTD increases(expression) CYP19A1 C016599 CTD decreases(activity) CYP19A1 C016599 CTD decreases(expression) CYP19A1 C016599 CTD increases(expression) CYP1A1 C016599 CTD increases(metabolic processing) CYP2C19 C016599 CTD increases(chemical synthesis) CYP2C19 C016599 CTD increases(metabolic processing) CYP2C9 C016599 CTD increases(chemical synthesis) CYP2C9 C016599 CTD increases(metabolic processing) CYP2C9 C016599 CTD increases(chemical synthesis) CYP2C9 C016599 CTD increases(metabolic processing) CYP3A4 C016599 CTD increases(chemical synthesis) CYP3A4 C016599 CTD increases(metabolic processing) CYP3A4 C016599 CTD increases(chemical synthesis) CYP3A4 C016599 CTD affects(cotreatment) CYP3A4 C016599 CTD increases(activity) CYP3A4 C016599 CTD increases(expression) DDIT3 C016599 CTD decreases(expression) DHCR24 C016599 CTD increases(expression) DNAJB1 C016599 CTD affects(binding) EP300 C016599 CTD increases(reaction) EP300 C016599 CTD increases(expression) FASN C016599 CTD decreases(reaction) FSHB C016599 CTD increases(abundance) FSHB C016599 CTD decreases(expression) FSHR C016599 CTD decreases(expression) GJA1 C016599 CTD increases(expression) GLRX2 C016599 CTD increases(expression) HMGCR C016599 CTD decreases(activity) HSD11B2 C016599 CTD increases(expression) HSPA1B C016599 CTD decreases(expression) ID1 C016599 CTD decreases(expression) IL17RD C016599 CTD decreases(expression) LFNG C016599 CTD decreases(expression) LHCGR C016599 CTD increases(expression) MARS C016599 CTD affects(binding) MED1 C016599 CTD increases(reaction) MED1 C016599 CTD increases(activity) MMP2 C016599 CTD increases(expression) MMP2 C016599 CTD increases(secretion) MMP2 C016599 CTD decreases(reaction) MMP2 C016599 CTD decreases(activity) MMP2 C016599 CTD decreases(response to substance) MMP2 C016599 CTD increases(expression) MYC C016599 CTD affects(binding) NCOR1 C016599 CTD decreases(reaction) NCOR1 C016599 CTD increases(expression) NR1H3 C016599 CTD affects(binding) NR1I2 C016599 CTD increases(activity) NR1I2 C016599 CTD decreases(expression) NR4A1 C016599 CTD increases(expression) NR4A1 C016599 CTD increases(expression) NR4A2 C016599 CTD increases(expression) NR4A3 C016599 CTD affects(binding) PPARA C016599 CTD increases(activity) PPARA C016599 CTD affects(binding) PPARA C016599 CTD decreases(reaction) PPARA C016599 CTD increases(reaction) PPARA C016599 CTD increases(activity) PPARA C016599 CTD increases(expression) PPARA C016599 CTD affects(binding) PPARD C016599 CTD decreases(reaction) PPARG C016599 CTD increases(activity) PPARG C016599 CTD increases(reaction) PPARG C016599 CTD affects(binding) PPARG C016599 CTD increases(activity) PPARG C016599 CTD affects(binding) PPARG C016599 CTD decreases(expression) PPARG C016599 CTD increases(activity) PPARG C016599 CTD affects(binding) PPARGC1A C016599 CTD increases(reaction) PPARGC1A C016599 CTD increases(expression) PRNP C016599 CTD increases(expression) PTGS2 C016599 CTD affects(binding) RXRA C016599 CTD affects(binding) RXRB C016599 CTD affects(binding) RXRG C016599 CTD decreases(expression) SCARA3 C016599 CTD increases(expression) SCD C016599 CTD increases(expression) SLC7A11 C016599 CTD increases(expression) SQLE C016599 CTD increases(expression) SREBF1 C016599 CTD increases(expression) SREBF2 C016599 CTD decreases(expression) STAR C016599 CTD increases(activity) TP53 C016599 CTD decreases(reaction) TP53 C016599 CTD increases(expression) TXNRD1 C016599 CTD decreases(expression) VCL C016599 CTD increases(expression) VLDLR C016599 CTD increases(expression) ZNF461 C016599 PubChem Potency uM 54.483 NFE2L2 - GI(Protien) : PubChem Potency-Replicate_1 uM 14.125 NR1I2 - GI(Protien) : PubChem Potency-Replicate_1 uM 39.601 NR3C1 - GI(Protien) : PubChem Potency-Replicate_1 uM 49.854 PPARD - GI(Protien) : PubChem Ratio Potency (uM) uM 3.343 PPARG - GI(Protien) : PubChem Potency uM 14.125 PPARG - GI(Protien) : PubChem None uM PPARG - GI(Protien) :
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