Tan Lab | DSigDB

Gene Set: D4 : CTD - diindolylmethane

Collection

D4 : CTD

Chemical Name

diindolylmethane ( From PubChem : 3,3'-DIINDOLYLMETHANE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
246.306 g/mol	2	0	4.24	True

Structure

InChI

InChI=1S/C17H14N2/c1-3-7-16-14(5-1)12(10-18-16)9-13-11-19-17-8-4-2-6-15(13)17/h1-8,10-11,18-19H,9H2

InChIKey

VFTRKSBEFQDZKX-UHFFFAOYSA-N

Links

Gene (104 / 234)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(expression)			ACTG1		C444299
CTD	increases(reaction)			ACTG1		C444299
CTD	affects(binding)			AHR		C016392
CTD	increases(activity)			AHR		C016392
CTD	affects(binding)			AHR		C016392
CTD	decreases(reaction)			AHR		C016392
CTD	increases(reaction)			AHR		C016392
CTD	increases(reaction)			AHR		C016392
CTD	decreases(reaction)			AHR		C016392
CTD	increases(expression)			AHR		C016392
CTD	increases(reaction)			AHR		C016392
CTD	affects(response to substance)			AHR		C016392
CTD	affects(localization)			AHR		C444299
CTD	affects(binding)			ARNT		C016392
CTD	increases(reaction)			ARNT		C016392
CTD	increases(expression)			ATF3		C016392
CTD	decreases(reaction)			ATP5A1		C444299
CTD	increases(expression)			ATP5A1		C444299
CTD	decreases(phosphorylation)			BAD		C016392
CTD	increases(expression)			BAX		C016392
CTD	increases(activity)			BBC3		C016392
CTD	increases(expression)			BBC3		C016392
CTD	increases(phosphorylation)			BBC3		C016392
CTD	decreases(expression)			BCL2		C016392
CTD	increases(reaction)			BCL2		C016392
CTD	decreases(expression)			BCL2		C016392
CTD	decreases(expression)			BCL2		C444299
CTD	increases(expression)			BCL2L1		C016392
CTD	increases(expression)			BCL2L10		C016392
CTD	decreases(expression)			BIRC5		C016392
CTD	decreases(reaction)			BRD2		C444299
CTD	increases(expression)			BRD2		C444299
CTD	decreases(expression)			CALM2		C444299
CTD	increases(reaction)			CALM2		C444299
CTD	decreases(expression)			CCNB1		C016392
CTD	decreases(expression)			CCND1		C016392
CTD	decreases(expression)			CCND1		C444299
CTD	decreases(reaction)			CCND1		C444299
CTD	decreases(expression)			CCND3		C016392
CTD	affects(methylation)			CCR4		C016392
CTD	increases(expression)			CD40LG		C016392
CTD	decreases(expression)			CDC25C		C016392
CTD	decreases(expression)			CDH11		C016392
CTD	affects(binding)			CDK2		C016392
CTD	increases(reaction)			CDK2		C016392
CTD	decreases(activity)			CDK2		C016392
CTD	decreases(expression)			CDK4		C016392
CTD	decreases(expression)			CDK6		C016392
CTD	affects(binding)			CDKN1A		C016392
CTD	increases(reaction)			CDKN1A		C016392
CTD	increases(expression)			CDKN1A		C016392
CTD	increases(expression)			CDKN1A		C016392
CTD	increases(expression)			CDKN1A		C444299
CTD	increases(expression)			CDKN1B		C016392
CTD	increases(expression)			CDKN2D		C016392
CTD	affects(binding)			CECR6		C016392
CTD	increases(reaction)			CECR6		C016392
CTD	increases(expression)			CECR6		C016392
CTD	affects(reaction)			CECR6		C016392
CTD	decreases(reaction)			CECR6		C016392
CTD	decreases(phosphorylation)			CHUK		C016392
CTD	decreases(expression)			CKS1B		C444299
CTD	increases(reaction)			CKS1B		C444299
CTD	decreases(expression)			COX2		C444299
CTD	decreases(reaction)			COX2		C444299
CTD	affects(methylation)			CXCR4		C016392
CTD	affects(localization)			CYCS		C444299
CTD	increases(expression)			CYCS		C444299
CTD	increases(expression)			CYP19A1		C444299
CTD	affects(binding)			CYP1A1		C016392
CTD	increases(reaction)			CYP1A1		C016392
CTD	decreases(activity)			CYP1A1		C016392
CTD	increases(expression)			CYP1A1		C016392
CTD	increases(abundance)			CYP1A1		C016392
CTD	increases(expression)			CYP1A1		C016392
CTD	increases(expression)			CYP1A1		C016392
CTD	increases(activity)			CYP1A1		C444299
CTD	increases(expression)			CYP1A1		C444299
CTD	decreases(activity)			CYP1A1		C444299
CTD	increases(expression)			CYP1A1		C444299
CTD	decreases(activity)			CYP1A2		C016392
CTD	increases(expression)			CYP1A2		C016392
CTD	increases(abundance)			CYP1A2		C016392
CTD	increases(expression)			CYP1A2		C016392
CTD	increases(expression)			CYP1A2		C016392
CTD	increases(oxidation)			CYP1A2		C016392
CTD	decreases(reaction)			CYP1A2		C016392
CTD	increases(expression)			CYP1B1		C444299
CTD	decreases(activity)			CYP3A4		C016392
CTD	affects(methylation)			CYR61		C016392
CTD	increases(expression)			DDIT3		C016392
CTD	decreases(expression)			DNMT1		C016392
CTD	decreases(expression)			DNMT3B		C016392
CTD	increases(expression)			EEF1G		C444299
CTD	increases(reaction)			EEF1G		C444299
CTD	decreases(activity)			ERBB2		C016392
CTD	decreases(phosphorylation)			ERBB2		C016392
CTD	increases(reaction)			ERBB2		C016392
CTD	affects(binding)			ESR1		C016392
CTD	increases(activity)			ESR1		C016392
CTD	increases(reaction)			ESR1		C016392
CTD	decreases(expression)			ESR1		C016392
CTD	increases(expression)			ESR1		C016392
CTD	increases(reaction)			ESR1		C016392
CTD	affects(binding)			ESR2		C016392
CTD	increases(reaction)			ESR2		C016392
CTD	increases(expression)			ESR2		C016392
CTD	affects(reaction)			ESR2		C016392
CTD	decreases(reaction)			ESR2		C016392
CTD	decreases(expression)			FAU		C444299
CTD	increases(reaction)			FAU		C444299
CTD	increases(expression)			GDF15		C016392
CTD	decreases(expression)			GNAS		C444299
CTD	decreases(reaction)			GNAS		C444299
CTD	increases(expression)			GREB1		C016392
CTD	decreases(phosphorylation)			GSK3B		C016392
CTD	decreases(expression)			GSTM1		C016392
CTD	increases(abundance)			GSTM1		C016392
CTD	increases(expression)			H3F3A		C444299
CTD	increases(reaction)			H3F3A		C444299
CTD	decreases(expression)			HDAC2		C016392
CTD	increases(expression)			HMOX1		C016392
CTD	increases(reaction)			HMOX1		C016392
CTD	decreases(reaction)			HMOX1		C016392
CTD	increases(expression)			HRK		C016392
CTD	decreases(reaction)			HSPB1		C444299
CTD	increases(expression)			HSPB1		C444299
CTD	increases(expression)			IL6		C016392
CTD	decreases(expression)			KLF10		C444299
CTD	decreases(reaction)			KLF10		C444299
CTD	decreases(reaction)			KRT18		C444299
CTD	increases(expression)			KRT18		C444299
CTD	affects(binding)			KRT19		C016392
CTD	increases(reaction)			KRT19		C016392
CTD	increases(expression)			KRT19		C016392
CTD	affects(reaction)			KRT19		C016392
CTD	decreases(reaction)			KRT19		C016392
CTD	decreases(reaction)			KRT19		C444299
CTD	increases(expression)			KRT19		C444299
CTD	decreases(reaction)			MAGEA9		C444299
CTD	increases(expression)			MAGEA9		C444299
CTD	decreases(phosphorylation)			MAPK1		C016392
CTD	decreases(reaction)			MAPK1		C016392
CTD	decreases(activity)			MAPK1		C016392
CTD	decreases(phosphorylation)			MAPK1		C016392
CTD	increases(reaction)			MAPK1		C016392
CTD	decreases(phosphorylation)			MAPK3		C016392
CTD	decreases(reaction)			MAPK3		C016392
CTD	decreases(activity)			MAPK3		C016392
CTD	decreases(phosphorylation)			MAPK3		C016392
CTD	increases(reaction)			MAPK3		C016392
CTD	decreases(expression)			MYC		C016392
CTD	decreases(reaction)			MYL6		C444299
CTD	increases(expression)			MYL6		C444299
CTD	affects(binding)			NCOA2		C016392
CTD	increases(reaction)			NCOA2		C016392
CTD	affects(reaction)			NCOA2		C016392
CTD	decreases(reaction)			NCOA2		C016392
CTD	increases(expression)			NCOA2		C016392
CTD	increases(expression)			NFE2L2		C016392
CTD	increases(reaction)			NFE2L2		C016392
CTD	increases(expression)			NQO1		C016392
CTD	increases(reaction)			NQO1		C016392
CTD	increases(expression)			NQO1		C016392
CTD	decreases(reaction)			NQO1		C016392
CTD	decreases(expression)			NUP133		C444299
CTD	decreases(reaction)			NUP133		C444299
CTD	decreases(reaction)			PAPOLA		C444299
CTD	increases(expression)			PAPOLA		C444299
CTD	affects(cotreatment)			PARP1		C016392
CTD	increases(activity)			PARP1		C016392
CTD	increases(cleavage)			PARP1		C016392
CTD	increases(expression)			PLAU		C016392
CTD	increases(activity)			PMAIP1		C016392
CTD	increases(expression)			PMAIP1		C016392
CTD	increases(phosphorylation)			PMAIP1		C016392
CTD	affects(binding)			PTGS2		C016392
CTD	decreases(reaction)			PTGS2		C016392
CTD	increases(reaction)			PTGS2		C016392
CTD	increases(expression)			PTGS2		C016392
CTD	decreases(expression)			PTGS2		C016392
CTD	decreases(expression)			PTGS2		C016392
CTD	decreases(expression)			RELA		C016392
CTD	decreases(reaction)			RIBC1		C444299
CTD	increases(expression)			RIBC1		C444299
CTD	decreases(reaction)			RNA28S5		C444299
CTD	increases(expression)			RNA28S5		C444299
CTD	decreases(reaction)			RPL10		C444299
CTD	increases(expression)			RPL10		C444299
CTD	increases(reaction)			RPL10		C444299
CTD	increases(expression)			RPL13A		C444299
CTD	increases(reaction)			RPL13A		C444299
CTD	decreases(reaction)			RPL31		C444299
CTD	increases(expression)			RPL31		C444299
CTD	decreases(expression)			RPL41		C444299
CTD	decreases(reaction)			RPL41		C444299
CTD	decreases(reaction)			RPL7		C444299
CTD	increases(expression)			RPL7		C444299
CTD	decreases(expression)			RPLP0		C444299
CTD	decreases(reaction)			RPLP0		C444299
CTD	decreases(expression)			RPS15A		C444299
CTD	decreases(reaction)			RPS15A		C444299
CTD	decreases(expression)			RPS17		C444299
CTD	decreases(reaction)			RPS17		C444299
CTD	decreases(reaction)			RPS3		C444299
CTD	increases(expression)			RPS3		C444299
CTD	increases(expression)			RPS4X		C444299
CTD	increases(reaction)			RPS4X		C444299
CTD	increases(expression)			RPS6		C444299
CTD	increases(reaction)			RPS6		C444299
CTD	affects(binding)			TFF1		C016392
CTD	increases(reaction)			TFF1		C016392
CTD	affects(methylation)			TGFBR1		C016392
CTD	decreases(expression)			TNF		C016392
CTD	increases(expression)			TNFRSF1A		C016392
CTD	decreases(expression)			TNFRSF25		C016392
CTD	increases(expression)			TNFSF8		C016392
CTD	increases(activity)			TP53		C016392
CTD	increases(expression)			TP53		C016392
CTD	increases(phosphorylation)			TP53		C016392
CTD	decreases(reaction)			TP53		C016392
CTD	decreases(expression)			TRAF4		C016392
CTD	decreases(reaction)			TYMS		C444299
CTD	increases(expression)			TYMS		C444299
CTD	increases(expression)			UBB		C444299
CTD	increases(reaction)			UBB		C444299
CTD	decreases(expression)			XIAP		C016392
CTD	decreases(reaction)			XRCC6		C444299
CTD	increases(expression)			XRCC6		C444299
PubChem	Potency	uM	8.912	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	50.119	VDR	-	GI(Protien) :
ChEMBL	Potency	nM	8912.500	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	15848.900	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	17782.800	MAPT	-	Target : CHEMBL1293224

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