Tan Lab | DSigDB

Gene Set: D4 : CTD - 1-(3-chlorophenyl)piperazine

Collection

D4 : CTD

Chemical Name

1-(3-chlorophenyl)piperazine ( From PubChem : 1-(3-CHLOROPHENYL)PIPERAZINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
196.677 g/mol	1	2	2.1434	True

Structure

InChI

InChI=1S/C10H13ClN2/c11-9-2-1-3-10(8-9)13-6-4-12-5-7-13/h1-3,8,12H,4-7H2

InChIKey

VHFVKMTVMIZMIK-UHFFFAOYSA-N

Links

Gene (15 / 63)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(metabolic processing)			CYP2D6		C015068
CTD	decreases(reaction)			CYP2D6		C015068
CTD	increases(expression)			CYP3A4		C015068
CTD	increases(reaction)			CYP3A4		C015068
CTD	decreases(reaction)			CYP3A4		C015068
CTD	affects(cotreatment)			GABBR2		C015068
CTD	affects(reaction)			GABBR2		C015068
CTD	increases(activity)			GABBR2		C015068
CTD	affects(cotreatment)			GABRA1		C015068
CTD	affects(reaction)			GABRA1		C015068
CTD	increases(activity)			GABRA1		C015068
CTD	affects(binding)			GABRA1		C015068
CTD	decreases(activity)			GABRA1		C015068
CTD	increases(reaction)			GABRA1		C015068
CTD	affects(binding)			GABRB2		C015068
CTD	decreases(activity)			GABRB2		C015068
CTD	increases(reaction)			GABRB2		C015068
CTD	affects(cotreatment)			GABRG2		C015068
CTD	affects(reaction)			GABRG2		C015068
CTD	increases(activity)			GABRG2		C015068
CTD	affects(binding)			GABRG2		C015068
CTD	decreases(activity)			GABRG2		C015068
CTD	increases(reaction)			GABRG2		C015068
CTD	affects(binding)			HTR2A		C015068
CTD	increases(activity)			HTR2A		C015068
CTD	increases(response to substance)			HTR2A		C015068
CTD	affects(response to substance)			HTR2A		C015068
CTD	increases(expression)			NR1I2		C015068
CTD	increases(reaction)			NR1I2		C015068
CTD	decreases(reaction)			NR1I2		C015068
CTD	increases(expression)			PRL		C015068
CTD	decreases(reaction)			PRL		C015068
CTD	increases(expression)			PRL		C015068
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	3.981	CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	25.119	CYP2D6	-	GI(Protien) :
PubChem	None	uM		CYP2D6	-	GI(Protien) :
PubChem	None	uM		HTR1D		GI(Protien) :
PubChem	None	uM		HTR1E		GI(Protien) :
PubChem	None	uM		HTR2A		GI(Protien) :
PubChem	None	uM		HTR2A		GI(Protien) :
PubChem	None	uM		HTR2A		GI(Protien) :
PubChem	None	uM		HTR2B		GI(Protien) :
PubChem	None	uM		HTR2B		GI(Protien) :
PubChem	None	uM		HTR2B		GI(Protien) :
PubChem	None	uM		HTR2B		GI(Protien) :
PubChem	None	uM		HTR2B		GI(Protien) :
PubChem	None	uM		HTR2C		GI(Protien) :
PubChem	None	uM		HTR2C		GI(Protien) :
PubChem	None	uM		HTR2C		GI(Protien) :
PubChem	None	uM		HTR2C		GI(Protien) :
PubChem	None	uM		HTR2C		GI(Protien) :
PubChem	None	uM		HTR2C		GI(Protien) :
PubChem	Potency	uM	8.912	THRB	-	GI(Protien) :
PubChem	Potency	uM	28.184	THRB	-	GI(Protien) :
ChEMBL	AC50	nM	15848.900	CYP1A2	-	Target : CHEMBL3356
ChEMBL	Potency	nM	25118.900	CYP2D6	-	Target : CHEMBL289
ChEMBL	AC50	nM	3981.070	CYP2D6	-	Target : CHEMBL289
ChEMBL	AC50	nM	25118.900	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	3981.100	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	8912.500	THRB	-	Target : CHEMBL1947
ChEMBL	Potency	nM	28183.800	THRB	-	Target : CHEMBL1947

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