Tan Lab | DSigDB

Gene Set: D4 : CTD - Apigenin

Collection

D4 : CTD

Chemical Name

Apigenin ( From PubChem : APIGENIN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
270.237 g/mol	3	5	2.5768	True

Structure

InChI

InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H

InChIKey

KZNIFHPLKGYRTM-UHFFFAOYSA-N

Links

Gene (112 / 302)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(activity)			ABCC1		D047310
CTD	decreases(reaction)			AHR		D047310
CTD	increases(phosphorylation)			AHR		D047310
CTD	affects(cotreatment)			AKT1		D047310
CTD	decreases(expression)			AKT1		D047310
CTD	decreases(expression)			AKT1		D047310
CTD	affects(cotreatment)			APAF1		D047310
CTD	increases(expression)			APAF1		D047310
CTD	decreases(reaction)			ARNT		D047310
CTD	increases(phosphorylation)			ARNT		D047310
CTD	increases(expression)			B3GALT5		D047310
CTD	affects(cotreatment)			BAX		D047310
CTD	increases(expression)			BAX		D047310
CTD	decreases(expression)			BCL2		D047310
CTD	decreases(response to substance)			BCL2		D047310
CTD	affects(cotreatment)			BCL2		D047310
CTD	decreases(expression)			BCL2		D047310
CTD	increases(cleavage)			BIRC3		D047310
CTD	increases(activity)			CASP3		D047310
CTD	increases(reaction)			CASP3		D047310
CTD	increases(activity)			CASP3		D047310
CTD	increases(cleavage)			CASP3		D047310
CTD	affects(cotreatment)			CASP3		D047310
CTD	increases(expression)			CASP3		D047310
CTD	increases(activity)			CASP7		D047310
CTD	increases(cleavage)			CASP7		D047310
CTD	increases(cleavage)			CASP8		D047310
CTD	increases(cleavage)			CASP9		D047310
CTD	affects(cotreatment)			CASP9		D047310
CTD	increases(expression)			CASP9		D047310
CTD	decreases(expression)			CAT		D047310
CTD	decreases(response to substance)			CAT		D047310
CTD	decreases(expression)			CCNB1		D047310
CTD	affects(cotreatment)			CD40		D047310
CTD	decreases(reaction)			CD40		D047310
CTD	increases(expression)			CD40		D047310
CTD	decreases(activity)			CDK1		D047310
CTD	increases(phosphorylation)			CDK1		D047310
CTD	increases(expression)			CDKN1A		D047310
CTD	increases(expression)			CDKN1A		D047310
CTD	affects(reaction)			CDKN1A		D047310
CTD	increases(expression)			CDKN1A		D047310
CTD	increases(expression)			CDKN2C		D047310
CTD	affects(localization)			CFTR		D047310
CTD	increases(activity)			CFTR		D047310
CTD	increases(activity)			CFTR		D047310
CTD	increases(expression)			CXCL12		D047310
CTD	decreases(reaction)			CXCL12		D047310
CTD	affects(localization)			CYCS		D047310
CTD	affects(cotreatment)			CYCS		D047310
CTD	affects(localization)			CYCS		D047310
CTD	decreases(expression)			CYP11B1		D047310
CTD	decreases(reaction)			CYP17A1		D047310
CTD	increases(expression)			CYP17A1		D047310
CTD	decreases(activity)			CYP19A1		D047310
CTD	decreases(expression)			CYP19A1		D047310
CTD	affects(binding)			CYP1A1		D047310
CTD	decreases(activity)			CYP1A1		D047310
CTD	decreases(reaction)			CYP1A1		D047310
CTD	increases(activity)			CYP1A1		D047310
CTD	decreases(reaction)			CYP1A1		D047310
CTD	increases(expression)			CYP1A1		D047310
CTD	decreases(activity)			CYP1A1		D047310
CTD	increases(expression)			CYP1A1		D047310
CTD	decreases(activity)			CYP1A2		D047310
CTD	affects(binding)			CYP1B1		D047310
CTD	decreases(activity)			CYP1B1		D047310
CTD	decreases(activity)			CYP1B1		D047310
CTD	increases(chemical synthesis)			CYP1B1		D047310
CTD	increases(metabolic processing)			CYP1B1		D047310
CTD	decreases(reaction)			CYP21A2		D047310
CTD	increases(expression)			CYP21A2		D047310
CTD	decreases(reaction)			CYP2C9		D047310
CTD	increases(hydroxylation)			CYP2C9		D047310
CTD	decreases(reaction)			CYP3A4		D047310
CTD	increases(chemical synthesis)			CYP3A4		D047310
CTD	increases(oxidation)			CYP3A4		D047310
CTD	increases(reaction)			CYP3A4		D047310
CTD	decreases(activity)			CYP3A4		D047310
CTD	affects(cotreatment)			ERBB2		D047310
CTD	decreases(expression)			ERBB2		D047310
CTD	affects(binding)			ESR1		D047310
CTD	increases(activity)			ESR1		D047310
CTD	affects(binding)			ESR1		D047310
CTD	decreases(reaction)			ESR1		D047310
CTD	decreases(expression)			ESR1		D047310
CTD	increases(activity)			ESR1		D047310
CTD	decreases(reaction)			ESR1		D047310
CTD	increases(expression)			ESR1		D047310
CTD	affects(binding)			ESR2		D047310
CTD	increases(activity)			ESR2		D047310
CTD	affects(binding)			ESR2		D047310
CTD	decreases(reaction)			ESR2		D047310
CTD	increases(activity)			ESR2		D047310
CTD	decreases(expression)			FBP1		D047310
CTD	decreases(reaction)			FOS		D047310
CTD	increases(activity)			FOS		D047310
CTD	increases(expression)			FOS		D047310
CTD	affects(binding)			FOS		D047310
CTD	decreases(reaction)			FOS		D047310
CTD	increases(activity)			FOS		D047310
CTD	increases(expression)			FOS		D047310
CTD	increases(expression)			GCLC		D047310
CTD	decreases(expression)			HIF1A		D047310
CTD	decreases(reaction)			HSD3B2		D047310
CTD	increases(expression)			HSD3B2		D047310
CTD	decreases(reaction)			ICAM1		D047310
CTD	increases(expression)			ICAM1		D047310
CTD	decreases(reaction)			IKBKB		D047310
CTD	increases(expression)			IKBKB		D047310
CTD	increases(activity)			IKBKB		D047310
CTD	increases(phosphorylation)			IKBKB		D047310
CTD	decreases(activity)			IKBKB		D047310
CTD	decreases(expression)			IKBKB		D047310
CTD	decreases(phosphorylation)			IKBKB		D047310
CTD	decreases(expression)			IL4		D047310
CTD	affects(binding)			JUN		D047310
CTD	decreases(reaction)			JUN		D047310
CTD	increases(activity)			JUN		D047310
CTD	increases(expression)			JUN		D047310
CTD	decreases(reaction)			MAPK1		D047310
CTD	increases(abundance)			MAPK1		D047310
CTD	increases(activity)			MAPK1		D047310
CTD	increases(phosphorylation)			MAPK1		D047310
CTD	decreases(reaction)			MAPK1		D047310
CTD	increases(activity)			MAPK1		D047310
CTD	decreases(reaction)			MAPK3		D047310
CTD	increases(abundance)			MAPK3		D047310
CTD	increases(activity)			MAPK3		D047310
CTD	increases(phosphorylation)			MAPK3		D047310
CTD	decreases(expression)			MMP1		D047310
CTD	decreases(reaction)			MMP9		D047310
CTD	increases(activity)			MMP9		D047310
CTD	increases(expression)			MMP9		D047310
CTD	affects(localization)			NFKB1		D047310
CTD	decreases(reaction)			NFKB1		D047310
CTD	affects(degradation)			NFKBIA		D047310
CTD	decreases(reaction)			NFKBIA		D047310
CTD	increases(degradation)			NFKBIA		D047310
CTD	decreases(reaction)			NFKBIA		D047310
CTD	increases(degradation)			NFKBIA		D047310
CTD	increases(phosphorylation)			NFKBIA		D047310
CTD	affects(binding)			NFKBIA		D047310
CTD	increases(phosphorylation)			NFKBIA		D047310
CTD	affects(binding)			NFKBIB		D047310
CTD	decreases(reaction)			NFKBIB		D047310
CTD	increases(phosphorylation)			NFKBIB		D047310
CTD	affects(cotreatment)			PARP1		D047310
CTD	increases(cleavage)			PARP1		D047310
CTD	affects(cotreatment)			PARP1		D047310
CTD	increases(cleavage)			PARP1		D047310
CTD	affects(binding)			PGR		D047310
CTD	decreases(reaction)			PGR		D047310
CTD	decreases(expression)			POU5F1		D047310
CTD	decreases(activity)			PRKAA1		D047310
CTD	decreases(phosphorylation)			PRKAA1		D047310
CTD	decreases(reaction)			PRKAA1		D047310
CTD	decreases(expression)			PSCA		D047310
CTD	affects(localization)			RELA		D047310
CTD	decreases(reaction)			RELA		D047310
CTD	increases(activity)			RELA		D047310
CTD	increases(expression)			RELA		D047310
CTD	affects(localization)			RELA		D047310
CTD	decreases(reaction)			RELA		D047310
CTD	increases(expression)			RELA		D047310
CTD	decreases(expression)			RPS6KB1		D047310
CTD	decreases(reaction)			SELE		D047310
CTD	increases(expression)			SELE		D047310
CTD	increases(sulfation)			SULT1A1		D047310
CTD	decreases(reaction)			SULT1E1		D047310
CTD	increases(expression)			SULT1E1		D047310
CTD	affects(localization)			TNF		D047310
CTD	decreases(reaction)			TNF		D047310
CTD	affects(localization)			TNF		D047310
CTD	decreases(reaction)			TNF		D047310
CTD	affects(binding)			TNF		D047310
CTD	decreases(reaction)			TNF		D047310
CTD	increases(activity)			TNF		D047310
CTD	increases(degradation)			TNF		D047310
CTD	increases(expression)			TNF		D047310
CTD	decreases(reaction)			TNF		D047310
CTD	increases(expression)			TNF		D047310
CTD	increases(expression)			TNF		D047310
CTD	decreases(reaction)			TNF		D047310
CTD	increases(expression)			TNF		D047310
CTD	increases(activity)			TNF		D047310
CTD	increases(phosphorylation)			TNF		D047310
CTD	increases(degradation)			TNF		D047310
CTD	increases(phosphorylation)			TNF		D047310
CTD	increases(expression)			TP53		D047310
CTD	affects(reaction)			TP53		D047310
CTD	increases(expression)			TP53		D047310
CTD	increases(expression)			TP53I3		D047310
CTD	increases(expression)			TP63		D047310
CTD	increases(expression)			TP73		D047310
CTD	increases(expression)			UGT1A1		D047310
CTD	increases(reaction)			UGT1A1		D047310
CTD	affects(cotreatment)			UGT1A1		D047310
CTD	increases(glucuronidation)			UGT1A1		D047310
CTD	increases(glucuronidation)			UGT1A10		D047310
CTD	increases(glucuronidation)			UGT1A7		D047310
CTD	increases(glucuronidation)			UGT1A8		D047310
CTD	increases(glucuronidation)			UGT1A9		D047310
CTD	increases(metabolic processing)			UGT2B15		D047310
CTD	increases(expression)			UTRN		D047310
CTD	decreases(reaction)			VCAM1		D047310
CTD	increases(expression)			VCAM1		D047310
CTD	decreases(expression)			VEGFA		D047310
CTD	increases(expression)			WISP2		D047310
CTD	decreases(reaction)			WISP2		D047310
PubChem	AhR Potency (uM)	uM	21.977	AHR	-	GI(Protien) :
PubChem	None	uM		AKR1C4	-	GI(Protien) :
PubChem	Potency	uM	1.778	ALDH1A1	-	GI(Protien) :
PubChem	Potency	uM	5.012	ALOX15	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	37.435	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	46.861	AR	-	GI(Protien) :
PubChem	Potency	uM	22.387	BRCA1	-	GI(Protien) :
PubChem	None	uM		CLK3	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	7.943	CYP2C19	-	GI(Protien) :
PubChem	None	uM		CYP2C19	-	GI(Protien) :
PubChem	Potency	uM	1.259	CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	3.162	CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	7.943	CYP3A4	-	GI(Protien) :
PubChem	None	uM		CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	3.981	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	7.867	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	9.771	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	10.291	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	10.963	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	10.965	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	41.205	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	54.483	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	61.940	ESR1	-	GI(Protien) :
PubChem	None	uM		GEM	-	GI(Protien) :
PubChem	None	uM		GNAI1	-	GI(Protien) :
PubChem	EC50_uM	uM	49.490	GSK3B	-	GI(Protien) :
PubChem	Potency	uM	12.589	HIF1A	-	GI(Protien) :
PubChem	Potency	uM	3.548	HPGD	-	GI(Protien) :
PubChem	Potency	uM	31.623	HPGD	-	GI(Protien) :
PubChem	None	uM		IL1B	-	GI(Protien) :
PubChem	Potency	uM	15.849	MAPT	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	22.837	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	24.337	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	33.492	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	25.119	NPSR1	-	GI(Protien) :
PubChem	None	uM		NR0B1	-	GI(Protien) :
PubChem	Potency	uM	44.668	NR1H4	-	GI(Protien) :
PubChem	None	uM		NR1H4	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	31.623	NR1I2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	44.668	NR1I2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	27.539	NR3C1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	27.913	NR3C1	-	GI(Protien) :
PubChem	Potency	uM	31.623	NR3C1	-	GI(Protien) :
PubChem	Potency	uM	3.264	PARK2	-	GI(Protien) :
PubChem	Potency	uM	16.360	PARK2	-	GI(Protien) :
PubChem	None	uM		PIM1	-	GI(Protien) :
PubChem	None	uM		PIM2	-	GI(Protien) :
PubChem	Potency	uM	19.953	POLK	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	17.376	PPARD	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	21.875	PPARG	-	GI(Protien) :
PubChem	Potency	uM	44.668	PPARG	-	GI(Protien) :
PubChem	None	uM		PPARG	-	GI(Protien) :
PubChem	None	uM		RGS12	-	GI(Protien) :
PubChem	None	uM		SENP6	-	GI(Protien) :
PubChem	None	uM		SENP6	-	GI(Protien) :
PubChem	None	uM		SENP7	-	GI(Protien) :
PubChem	None	uM		SENP8	-	GI(Protien) :
PubChem	None	uM		SENP8	-	GI(Protien) :
PubChem	None	uM		SENP8	-	GI(Protien) :
PubChem	Potency	uM	14.125	SMN2	-	GI(Protien) :
PubChem	Potency	uM	22.387	SMN2	-	GI(Protien) :
PubChem	None	uM		STK16	-	GI(Protien) :
PubChem	Potency	uM	5.173	TDP1	-	GI(Protien) :
PubChem	Potency	uM	12.995	TDP1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	48.972	VDR	-	GI(Protien) :
PubChem	None	uM		VDR	-	GI(Protien) :
ChEMBL	Potency	nM	1778.300	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	5011.900	ALOX15	-	Target : CHEMBL2903
ChEMBL	Inhibition	-		CYBB	-	Target : CHEMBL1287627
ChEMBL	Inhibition	-		CYBB	-	Target : CHEMBL1287627
ChEMBL	Inhibition	-		CYBB	-	Target : CHEMBL1287627
ChEMBL	Inhibition	-		CYBB	-	Target : CHEMBL1287627
ChEMBL	AC50	nM	63.100	CYP1A2	-	Target : CHEMBL3356
ChEMBL	AC50	nM	125.890	CYP1A2	-	Target : CHEMBL3356
ChEMBL	AC50	nM	7943.280	CYP2C19	-	Target : CHEMBL3622
ChEMBL	Potency	nM	7943.300	CYP2C19	-	Target : CHEMBL3622
ChEMBL	AC50	nM	1258.930	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	3162.300	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	7943.300	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	1258.900	CYP3A4	-	Target : CHEMBL340
ChEMBL	AC50	nM	3162.280	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	12589.300	HIF1A	-	Target : CHEMBL4261
ChEMBL	Potency	nM	31622.800	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	3548.100	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	398.100	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	11220.200	KDM4E	-	Target : CHEMBL1293226
ChEMBL	Potency	nM	15848.900	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	25118.900	NPSR1	-	Target : CHEMBL5162
ChEMBL	Potency	nM	22387.200	SMN1; SMN2	-	Target : CHEMBL1293232
ChEMBL	Potency	nM	14125.400	SMN1; SMN2	-	Target : CHEMBL1293232

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