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Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : CTD - alpha-Tocopherol

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Collection	D4 : CTD
Chemical Name	alpha-Tocopherol ( From PubChem : ALPHA-TOCOPHEROL )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Approved Not Not Approved Approved Approved Approved Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 430.706 g/mol 1 2 8.8402 False(3/4)
Structure
InChI	InChI=1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3/t21-,22-,29-/m1/s1
InChIKey	GVJHHUAWPYXKBD-IEOSBIPESA-N
Links
Gene (58 / 150) ⊖ Less	Source Type Unit Value Gene PMID Assay Other CTD decreases(expression) APOA1 D024502 CTD increases(reaction) APOB D024502 CTD increases(reduction) APOB D024502 CTD decreases(reaction) APP D024502 CTD increases(activity) APP D024502 CTD decreases(reaction) ATF2 D024502 CTD increases(phosphorylation) ATF2 D024502 CTD decreases(reaction) BACE1 D024502 CTD increases(expression) BACE1 D024502 CTD affects(reaction) BAX D024502 CTD increases(expression) BAX D024502 CTD affects(reaction) BCL2 D024502 CTD decreases(expression) BCL2 D024502 CTD decreases(expression) BCL2 D024502 CTD decreases(reaction) BCL2 D024502 CTD affects(reaction) BCL2 D024502 CTD affects(cotreatment) CASP3 D024502 CTD increases(activity) CASP3 D024502 CTD affects(cotreatment) CASP3 D024502 CTD increases(activity) CASP3 D024502 CTD decreases(reaction) CASP3 D024502 CTD increases(activity) CASP3 D024502 CTD decreases(reaction) CASP3 D024502 CTD increases(activity) CASP3 D024502 CTD decreases(reaction) CASP3 D024502 CTD increases(activity) CASP3 D024502 CTD increases(reaction) CASP3 D024502 CTD decreases(activity) CASP3 D024502 CTD increases(reaction) CASP3 D024502 CTD decreases(activity) CASP3 D024502 CTD increases(activity) CASP3 D024502 CTD increases(cleavage) CASP3 D024502 CTD increases(activity) CASP7 D024502 CTD increases(reaction) CASP7 D024502 CTD increases(cleavage) CASP8 D024502 CTD increases(cleavage) CASP9 D024502 CTD increases(activity) CASP9 D024502 CTD increases(cleavage) CASP9 D024502 CTD increases(expression) CAT D024502 CTD decreases(expression) CFTR D024502 CTD decreases(reaction) CFTR D024502 CTD affects(cotreatment) CRABP2 D024502 CTD increases(expression) CRABP2 D024502 CTD affects(cotreatment) CRP D024502 CTD decreases(expression) CRP D024502 CTD decreases(reaction) CXCL8 D024502 CTD increases(secretion) CXCL8 D024502 CTD increases(expression) DDIT3 D024502 CTD decreases(reaction) DDIT3 D024502 CTD affects(reaction) DDIT3 D024502 CTD decreases(expression) DDIT3 D024502 CTD increases(phosphorylation) EIF2A D024502 CTD decreases(reaction) EIF2A D024502 CTD decreases(reaction) FN1 D024502 CTD increases(expression) FN1 D024502 CTD increases(secretion) FN1 D024502 CTD decreases(reaction) FYN D024502 CTD increases(phosphorylation) FYN D024502 CTD affects(cotreatment) GCLC D024502 CTD increases(expression) GCLC D024502 CTD affects(cotreatment) GCLM D024502 CTD increases(expression) GCLM D024502 CTD decreases(reaction) GPX4 D024502 CTD increases(expression) GPX4 D024502 CTD increases(expression) HBG2 D024502 CTD affects(expression) HMOX1 D024502 CTD decreases(reaction) HMOX1 D024502 CTD increases(expression) HMOX1 D024502 CTD affects(activity) HP D024502 CTD decreases(reaction) ICAM1 D024502 CTD increases(expression) ICAM1 D024502 CTD decreases(reaction) IL6 D024502 CTD increases(expression) IL6 D024502 CTD increases(secretion) IL6 D024502 CTD decreases(reaction) JUN D024502 CTD increases(phosphorylation) JUN D024502 CTD decreases(reaction) LCK D024502 CTD increases(phosphorylation) LCK D024502 CTD decreases(reaction) LYN D024502 CTD increases(phosphorylation) LYN D024502 CTD decreases(phosphorylation) MAPK1 D024502 CTD decreases(reaction) MAPK1 D024502 CTD affects(cotreatment) MAPK14 D024502 CTD decreases(reaction) MAPK14 D024502 CTD increases(activity) MAPK14 D024502 CTD decreases(reaction) MAPK14 D024502 CTD increases(activity) MAPK14 D024502 CTD decreases(phosphorylation) MAPK3 D024502 CTD decreases(reaction) MAPK3 D024502 CTD decreases(reaction) MAPK3 D024502 CTD increases(activity) MAPK3 D024502 CTD increases(phosphorylation) MAPK8 D024502 CTD decreases(reaction) MAPK8 D024502 CTD increases(activity) MAPK8 D024502 CTD decreases(reaction) MAPK8 D024502 CTD increases(activity) MAPK8 D024502 CTD decreases(reaction) MAPK8 D024502 CTD increases(phosphorylation) MAPK9 D024502 CTD decreases(reaction) MAPK9 D024502 CTD decreases(reaction) MBP D024502 CTD increases(expression) MBP D024502 CTD increases(activity) NFKB1 D024502 CTD increases(expression) NOS3 D024502 CTD affects(localization) PARK7 D024502 CTD decreases(reaction) PARK7 D024502 CTD decreases(reaction) PARP1 D024502 CTD increases(cleavage) PARP1 D024502 CTD decreases(reaction) PGK1 D024502 CTD increases(expression) PGK1 D024502 CTD decreases(activity) PLG D024502 CTD decreases(reaction) PLG D024502 CTD increases(reaction) PLG D024502 CTD increases(activity) PPARG D024502 CTD increases(expression) PPARG D024502 CTD decreases(activity) PTGS2 D024502 CTD affects(localization) RELA D024502 CTD affects(cotreatment) RXRA D024502 CTD decreases(phosphorylation) RXRA D024502 CTD decreases(reaction) SELE D024502 CTD increases(expression) SELE D024502 CTD affects(cotreatment) SLC7A11 D024502 CTD increases(expression) SLC7A11 D024502 CTD affects(cotreatment) SMAD4 D024502 CTD decreases(response to substance) SMAD4 D024502 CTD decreases(reaction) SNCA D024502 CTD increases(expression) SNCA D024502 CTD increases(expression) SOD1 D024502 CTD decreases(activity) TERT D024502 CTD decreases(reaction) TERT D024502 CTD affects(cotreatment) TNF D024502 CTD decreases(expression) TNF D024502 CTD decreases(reaction) TNF D024502 CTD increases(expression) TNF D024502 CTD decreases(reaction) TNF D024502 CTD increases(secretion) TNF D024502 CTD decreases(reaction) TNF D024502 CTD increases(abundance) TNF D024502 CTD increases(activity) TNF D024502 CTD increases(reaction) TNF D024502 CTD increases(expression) TNFRSF10B D024502 CTD decreases(reaction) TNFRSF10B D024502 CTD affects(reaction) TNFRSF10B D024502 CTD decreases(expression) TNFRSF10B D024502 CTD decreases(reaction) TP53 D024502 CTD increases(expression) TP53 D024502 CTD decreases(reaction) VCAM1 D024502 CTD increases(expression) VCAM1 D024502 CTD decreases(reaction) VCAM1 D024502 CTD increases(expression) VCAM1 D024502 CTD increases(expression) XBP1 D024502
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