Tan Lab | DSigDB

Gene Set: D4 : CTD - Rolipram

Collection

D4 : CTD

Chemical Name

Rolipram ( From PubChem : ROLIPRAM )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Approved	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
275.343 g/mol	1	4	2.9489	True

Structure

InChI

InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m1/s1

InChIKey

Links

Gene (15 / 35)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(expression)			AREG		D020889
CTD	affects(secretion)			CFTR		D020889
CTD	increases(reaction)			CFTR		D020889
CTD	decreases(activity)			CFTR		D020889
CTD	increases(activity)			CFTR		D020889
CTD	decreases(secretion)			CXCL10		D020889
CTD	decreases(secretion)			IL10		D020889
CTD	decreases(expression)			IL13		D020889
CTD	decreases(secretion)			IL13		D020889
CTD	increases(abundance)			IL1B		D020889
CTD	increases(reaction)			IL1B		D020889
CTD	decreases(secretion)			LTC4S		D020889
CTD	affects(cotreatment)			PDE4A		D020889
CTD	increases(expression)			PDE4A		D020889
CTD	affects(cotreatment)			PDE4B		D020889
CTD	increases(expression)			PDE4B		D020889
CTD	affects(cotreatment)			SELE		D020889
CTD	decreases(reaction)			SELE		D020889
CTD	increases(expression)			SELE		D020889
CTD	increases(secretion)			SELE		D020889
CTD	affects(cotreatment)			TNF		D020889
CTD	decreases(reaction)			TNF		D020889
CTD	increases(expression)			TNF		D020889
CTD	increases(secretion)			TNF		D020889
CTD	decreases(reaction)			TNF		D020889
CTD	increases(expression)			TNF		D020889
CTD	decreases(secretion)			TNF		D020889
PubChem	None	uM		CFTR	-	GI(Protien) :
PubChem	IC50_CF-PAF_Mean	uM		CFTR	-	GI(Protien) :
PubChem	None	uM		CFTR	-	GI(Protien) :
PubChem	None	uM		DRD1	-	GI(Protien) :
PubChem	None	uM		DRD2	-	GI(Protien) :
PubChem	None	uM		DRD2	-	GI(Protien) :
PubChem	Potency	uM	0.046	GLP1R	-	GI(Protien) :
ChEMBL	Inhibition	-		ADRB2	-	Target : CHEMBL210

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