Tan Lab | DSigDB

Gene Set: D4 : CTD - 4-hydroxyestradiol

Collection

D4 : CTD

Chemical Name

4-hydroxyestradiol ( From PubChem : 1,3,5[10]-ESTRATRIENE-3,4,17 BETA-TRIOL )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
288.381 g/mol	3	3	3.3148	True

Structure

InChI

InChI=1S/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11-,12-,14-,16+,18+/m1/s1

InChIKey

QOZFCKXEVSGWGS-GTQMNPBKSA-N

Links

Gene (43 / 80)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(reaction)			AKT1		C014036
CTD	increases(phosphorylation)			AKT1		C014036
CTD	increases(activity)			ALPPL2		C014036
CTD	increases(expression)			ATP6		C014036
CTD	increases(expression)			CCND1		C014036
CTD	affects(metabolic processing)			COMT		C014036
CTD	increases(methylation)			COMT		C014036
CTD	decreases(reaction)			COMT		C014036
CTD	increases(expression)			COX3		C014036
CTD	increases(chemical synthesis)			CYP1B1		C014036
CTD	affects(chemical synthesis)			CYP1B1		C014036
CTD	affects(cotreatment)			CYP1B1		C014036
CTD	affects(metabolic processing)			CYP1B1		C014036
CTD	decreases(reaction)			CYP1B1		C014036
CTD	affects(binding)			ESR1		C014036
CTD	affects(binding)			ESR1		C014036
CTD	decreases(reaction)			ESR1		C014036
CTD	affects(binding)			ESR1		C014036
CTD	increases(activity)			ESR1		C014036
CTD	increases(reaction)			ESR1		C014036
CTD	increases(expression)			ESR1		C014036
CTD	affects(binding)			ESR2		C014036
CTD	decreases(expression)			ESR2		C014036
CTD	decreases(expression)			FOXO1		C014036
CTD	decreases(reaction)			HIF1A		C014036
CTD	increases(expression)			HIF1A		C014036
CTD	increases(expression)			IGF1R		C014036
CTD	increases(abundance)			LEP		C014036
CTD	increases(activity)			MAPK1		C014036
CTD	increases(phosphorylation)			MAPK1		C014036
CTD	decreases(reaction)			MAPK1		C014036
CTD	increases(activity)			MAPK3		C014036
CTD	increases(phosphorylation)			MAPK3		C014036
CTD	decreases(reaction)			MAPK3		C014036
CTD	increases(expression)			MYC		C014036
CTD	affects(binding)			NFKB1		C014036
CTD	increases(activity)			NFKB1		C014036
CTD	affects(cotreatment)			PTGS2		C014036
CTD	increases(expression)			PTGS2		C014036
CTD	decreases(reaction)			PTGS2		C014036
CTD	increases(reaction)			PTGS2		C014036
CTD	affects(binding)			RELA		C014036
CTD	increases(activity)			RELA		C014036
CTD	increases(expression)			SHBG		C014036
CTD	affects(binding)			TFF1		C014036
CTD	increases(activity)			TFF1		C014036
CTD	increases(reaction)			TFF1		C014036
CTD	increases(metabolic processing)			UGT2B15		C014036
CTD	decreases(reaction)			VEGFA		C014036
CTD	increases(expression)			VEGFA		C014036
PubChem	None	uM		APOBEC3G	-	GI(Protien) :
PubChem	Potency	uM	56.234	BAZ2B	-	GI(Protien) :
PubChem	None	uM		CBFB	-	GI(Protien) :
PubChem	None	uM		CBFB	-	GI(Protien) :
PubChem	IC50	uM		CBFB	-	GI(Protien) :
PubChem	Potency	uM	15.849	CBX1	-	GI(Protien) :
PubChem	None	uM		DLD	-	GI(Protien) :
PubChem	None	uM		EIF4G1	-	GI(Protien) :
PubChem	Potency	uM	8.845	GAA	-	GI(Protien) :
PubChem	None	uM		GAPDH	-	GI(Protien) :
PubChem	None	uM		GSTO1	-	GI(Protien) :
PubChem	Potency	uM	14.125	MAPT	-	GI(Protien) :
PubChem	None	uM		MCL1	-	GI(Protien) :
PubChem	IC50	uM	29.007	MPI	-	GI(Protien) :
PubChem	IC50	uM		MPI	-	GI(Protien) :
PubChem	None	uM		PRMT1	-	GI(Protien) :
PubChem	None	uM		PTGER2	-	GI(Protien) :
PubChem	None	uM		RUNX1	-	GI(Protien) :
PubChem	None	uM		RUNX1	-	GI(Protien) :
PubChem	IC50	uM		RUNX1	-	GI(Protien) :
PubChem	None	uM		SENP8	-	GI(Protien) :
PubChem	Potency	uM	12.995	TDP1	-	GI(Protien) :
PubChem	Potency	uM	25.929	TDP1	-	GI(Protien) :
PubChem	None	uM		VCP	-	GI(Protien) :
ChEMBL	Potency	nM	56234.100	BAZ2B	-	Target : CHEMBL1741220
ChEMBL	Potency	nM	8844.500	GAA	-	Target : CHEMBL2608
ChEMBL	Potency	nM	8912.500	KDM4A	-	Target : CHEMBL5896
ChEMBL	Potency	nM	1412.500	KDM4E	-	Target : CHEMBL1293226
ChEMBL	Potency	nM	14125.400	MAPT	-	Target : CHEMBL1293224
ChEMBL	IC50	nM	29007.000	MPI	-	Target : CHEMBL2758

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