Tan Lab | DSigDB

Gene Set: D4 : CTD - Nevirapine

Collection

D4 : CTD

Chemical Name

Nevirapine ( From PubChem : NEVIRAPINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Approved	Approved	Approved	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
266.298 g/mol	1	4	2.4783	True

Structure

InChI

InChI=1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)

InChIKey

NQDJXKOVJZTUJA-UHFFFAOYSA-N

Links

Gene (38 / 49)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(expression)			ADIPOQ		D019829
CTD	increases(secretion)			ADIPOQ		D019829
CTD	affects(binding)			ALB		D019829
CTD	increases(expression)			APOA1		D019829
CTD	increases(expression)			AR		D019829
CTD	increases(expression)			CEBPA		D019829
CTD	increases(expression)			CETP		D019829
CTD	increases(activity)			CYP2B6		D019829
CTD	increases(expression)			CYP2B6		D019829
CTD	affects(binding)			CYP3A4		D019829
CTD	decreases(expression)			EGF		D019829
CTD	decreases(expression)			EGFR		D019829
CTD	decreases(secretion)			HGF		D019829
CTD	increases(expression)			IFNG		D019829
CTD	decreases(secretion)			IL6		D019829
CTD	increases(expression)			KLK3		D019829
CTD	increases(expression)			KRT18		D019829
CTD	increases(expression)			LCAT		D019829
CTD	increases(expression)			LEP		D019829
CTD	increases(expression)			LPL		D019829
CTD	increases(activity)			NR1I3		D019829
CTD	increases(expression)			NR1I3		D019829
CTD	increases(expression)			PPARG		D019829
CTD	affects(cotreatment)			SLC5A5		D019829
CTD	increases(expression)			SLC5A5		D019829
CTD	increases(expression)			SREBF1		D019829
CTD	increases(expression)			TG		D019829
CTD	increases(expression)			TPO		D019829
CTD	affects(cotreatment)			TSHB		D019829
CTD	increases(expression)			TSHB		D019829
CTD	affects(abundance)			TSHB		D019829
CTD	increases(reaction)			TSHB		D019829
CTD	decreases(reaction)			TSHB		D019829
CTD	increases(expression)			TSHR		D019829
CTD	increases(expression)			UCP1		D019829
CTD	decreases(expression)			VEGFA		D019829
PubChem	Potency	uM	6.513	TDP1	-	GI(Protien) :
PubChem	Potency	uM	8.200	TDP1	-	GI(Protien) :
ChEMBL	Inhibition	-		ABCB1	-	Target : CHEMBL4302
ChEMBL	Activity	-		ABCB1	-	Target : CHEMBL4302
ChEMBL	Activity	-		ABCC1	-	Target : CHEMBL3004
ChEMBL	Activity	-		ABCC2	-	Target : CHEMBL5748
ChEMBL	Activity	-		ABCC3	-	Target : CHEMBL5918
ChEMBL	Inhibition	-		ABCG2	-	Target : CHEMBL5393
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2C19	-	Target : CHEMBL3622
ChEMBL	Inhibition	-		CYP2C9	-	Target : CHEMBL3397
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340

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