Tan Lab | DSigDB

Gene Set: D4 : CTD - Cholic Acid

Collection

D4 : CTD

Chemical Name

Cholic Acid ( From PubChem : 3,7,12-TRIHYDROXYCHOLAN-24-OIC ACID )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
408.571 g/mol	4	5	3.4487	True

Structure

InChI

InChI=1S/C24H40O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29)

InChIKey

Links

Gene (12 / 29)

⊖ Less

Source	Type	Unit	Gene	PMID	Other
CTD	decreases(reaction)		ABCB11		D019826
CTD	increases(transport)		ABCB11		D019826
CTD	decreases(activity)		ABCB11		D019826
CTD	decreases(reaction)		ABCC1		D019826
CTD	increases(export)		ABCC1		D019826
CTD	increases(oxidation)		CYP3A4		D019826
CTD	increases(reaction)		CYP3A4		D019826
CTD	affects(binding)		FGF19		D019826
CTD	increases(activity)		FGF19		D019826
CTD	affects(binding)		FGF19		D019826
CTD	increases(activity)		FGF19		D019826
CTD	increases(expression)		FGF19		D019826
CTD	affects(binding)		GPBAR1		D019826
CTD	increases(activity)		GPBAR1		D019826
CTD	affects(binding)		NR1H4		D019826
CTD	increases(activity)		NR1H4		D019826
CTD	affects(binding)		NR1H4		D019826
CTD	increases(activity)		NR1H4		D019826
CTD	affects(binding)		NR1H4		D019826
CTD	increases(expression)		NR1H4		D019826
CTD	decreases(reaction)		SLC27A5		D019826
CTD	increases(uptake)		SLC27A5		D019826
CTD	increases(uptake)		SLCO1B1		D019826
CTD	increases(abundance)		SLCO1B1		D019826
CTD	increases(uptake)		SLCO1B3		D019826
CTD	increases(sulfation)		SULT2A1		D019826
CTD	increases(localization)		VDR		D019826
ChEMBL	Activity	-	ABCB11	-	Target : CHEMBL6020
ChEMBL	Activity	-	PLA2G1B	-	Target : CHEMBL4426

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