Tan Lab | DSigDB

Gene Set: D4 : CTD - 17-alpha-Hydroxyprogesterone

Collection

D4 : CTD

Chemical Name

17-alpha-Hydroxyprogesterone ( From PubChem : HYDROXYPROGESTERONE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Approved	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
330.461 g/mol	1	3	3.8384	True

Structure

InChI

InChI=1S/C21H30O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h12,16-18,24H,4-11H2,1-3H3/t16-,17+,18+,19+,20+,21+/m1/s1

InChIKey

DBPWSSGDRRHUNT-CEGNMAFCSA-N

Links

Gene (8 / 27)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(activity)			AR		D019326
CTD	affects(abundance)			CYP17A1		D019326
CTD	affects(chemical synthesis)			CYP17A1		D019326
CTD	affects(metabolic processing)			CYP17A1		D019326
CTD	decreases(reaction)			CYP17A1		D019326
CTD	decreases(metabolic processing)			CYP21A2		D019326
CTD	increases(metabolic processing)			CYP21A2		D019326
CTD	affects(binding)			NR3C1		D019326
CTD	increases(activity)			NR3C1		D019326
CTD	affects(binding)			PGR		D019326
CTD	increases(activity)			PGR		D019326
CTD	decreases(reaction)			SLC22A2		D019326
CTD	increases(uptake)			SLC22A2		D019326
CTD	affects(metabolic processing)			TNF		D019326
CTD	decreases(reaction)			TNF		D019326
PubChem	Ratio Potency (uM)	uM	0.001	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.002	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.003	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	3.857	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	10.591	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	1.333	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	15.089	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	20.491	ESR1	-	GI(Protien) :
PubChem	Potency	uM	22.387	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.275	NR3C1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	1.068	NR3C1	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :

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