Tan Lab | DSigDB

Gene Set: D4 : CTD - beta-Naphthoflavone

Collection

D4 : CTD

Chemical Name

beta-Naphthoflavone ( From PubChem : 5,6-BENZOFLAVONE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
272.297 g/mol	0	2	4.6132	True

Structure

InChI

InChI=1S/C19H12O2/c20-16-12-18(14-7-2-1-3-8-14)21-17-11-10-13-6-4-5-9-15(13)19(16)17/h1-12H

InChIKey

OUGIDAPQYNCXRA-UHFFFAOYSA-N

Links

Gene (182 / 290)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(expression)			ABCC2		D019324
CTD	increases(expression)			ABCG2		D019324
CTD	increases(expression)			ADM		D019324
CTD	increases(expression)			ADRM1		D019324
CTD	increases(expression)			AHR		D019324
CTD	increases(reaction)			AHR		D019324
CTD	affects(binding)			AHR		D019324
CTD	decreases(reaction)			AHR		D019324
CTD	increases(activity)			AHR		D019324
CTD	affects(reaction)			AHR		D019324
CTD	decreases(expression)			AHR		D019324
CTD	affects(response to substance)			AHR		D019324
CTD	affects(localization)			AHR		D019324
CTD	affects(binding)			AHR		D019324
CTD	affects(binding)			AHR		D019324
CTD	affects(binding)			AHR		D019324
CTD	increases(activity)			AHR		D019324
CTD	affects(binding)			AHR		D019324
CTD	increases(activity)			AHR		D019324
CTD	affects(binding)			AHR		D019324
CTD	decreases(response to substance)			AHR		D019324
CTD	increases(activity)			AHR		D019324
CTD	increases(expression)			AHR		D019324
CTD	decreases(reaction)			AHR		D019324
CTD	increases(activity)			AHR		D019324
CTD	affects(binding)			AHR		D019324
CTD	increases(reaction)			AHR		D019324
CTD	affects(binding)			AHR		D019324
CTD	increases(expression)			AHR		D019324
CTD	increases(reaction)			AHR		D019324
CTD	decreases(expression)			AHR		D019324
CTD	increases(activity)			AHR		D019324
CTD	affects(binding)			AHR		D019324
CTD	decreases(chemical synthesis)			AHR		D019324
CTD	decreases(secretion)			AHR		D019324
CTD	increases(activity)			AHR		D019324
CTD	affects(binding)			AHR		D019324
CTD	decreases(reaction)			AHR		D019324
CTD	increases(activity)			AHR		D019324
CTD	increases(expression)			AKR1A1		D019324
CTD	increases(expression)			AKR1C1		D019324
CTD	increases(expression)			AKR1C3		D019324
CTD	decreases(expression)			AKR1D1		D019324
CTD	decreases(expression)			ALDH8A1		D019324
CTD	increases(expression)			ALOX5		D019324
CTD	decreases(expression)			APOA5		D019324
CTD	affects(binding)			ARNT		D019324
CTD	increases(reaction)			ARNT		D019324
CTD	affects(binding)			ARNT		D019324
CTD	increases(activity)			ARNT		D019324
CTD	increases(expression)			ASNS		D019324
CTD	increases(expression)			BRINP1		D019324
CTD	increases(expression)			C10ORF10		D019324
CTD	decreases(expression)			CASP1		D019324
CTD	increases(expression)			CBR1		D019324
CTD	increases(expression)			CDC42EP2		D019324
CTD	increases(expression)			CDK5RAP2		D019324
CTD	increases(expression)			CLIC1		D019324
CTD	increases(expression)			COLEC12		D019324
CTD	increases(expression)			CREM		D019324
CTD	decreases(expression)			CTGF		D019324
CTD	increases(chemical synthesis)			CYP11B1		D019324
CTD	increases(reaction)			CYP11B1		D019324
CTD	increases(expression)			CYP11B1		D019324
CTD	increases(expression)			CYP19A1		D019324
CTD	decreases(reaction)			CYP1A1		D019324
CTD	increases(expression)			CYP1A1		D019324
CTD	affects(reaction)			CYP1A1		D019324
CTD	decreases(expression)			CYP1A1		D019324
CTD	decreases(reaction)			CYP1A1		D019324
CTD	increases(activity)			CYP1A1		D019324
CTD	increases(expression)			CYP1A1		D019324
CTD	increases(reaction)			CYP1A1		D019324
CTD	increases(expression)			CYP1A1		D019324
CTD	increases(reaction)			CYP1A1		D019324
CTD	decreases(activity)			CYP1A1		D019324
CTD	increases(activity)			CYP1A1		D019324
CTD	increases(activity)			CYP1A1		D019324
CTD	increases(activity)			CYP1A1		D019324
CTD	increases(expression)			CYP1A1		D019324
CTD	increases(expression)			CYP1A1		D019324
CTD	increases(expression)			CYP1A1		D019324
CTD	decreases(reaction)			CYP1A2		D019324
CTD	increases(activity)			CYP1A2		D019324
CTD	affects(metabolic processing)			CYP1A2		D019324
CTD	increases(reaction)			CYP1A2		D019324
CTD	decreases(activity)			CYP1A2		D019324
CTD	increases(activity)			CYP1A2		D019324
CTD	increases(expression)			CYP1A2		D019324
CTD	increases(expression)			CYP1A2		D019324
CTD	affects(binding)			CYP1B1		D019324
CTD	decreases(activity)			CYP1B1		D019324
CTD	increases(expression)			CYP1B1		D019324
CTD	increases(expression)			CYP2A13		D019324
CTD	increases(expression)			CYP2A6		D019324
CTD	increases(activity)			CYP2B6		D019324
CTD	increases(expression)			CYP2B6		D019324
CTD	decreases(expression)			CYP2C18		D019324
CTD	decreases(expression)			CYP2C19		D019324
CTD	decreases(reaction)			CYP2C9		D019324
CTD	increases(hydroxylation)			CYP2C9		D019324
CTD	decreases(expression)			CYP2C9		D019324
CTD	decreases(expression)			CYP2D6		D019324
CTD	decreases(expression)			CYP2E1		D019324
CTD	decreases(expression)			CYP2W1		D019324
CTD	affects(binding)			CYP3A4		D019324
CTD	decreases(expression)			CYP3A4		D019324
CTD	increases(expression)			CYP3A4		D019324
CTD	decreases(expression)			CYP3A7		D019324
CTD	decreases(expression)			CYP4B1		D019324
CTD	decreases(expression)			CYP51A1		D019324
CTD	decreases(expression)			CYP7A1		D019324
CTD	increases(expression)			CYP7B1		D019324
CTD	increases(expression)			DEFA3		D019324
CTD	decreases(expression)			DEFB1		D019324
CTD	decreases(expression)			DGAT2		D019324
CTD	decreases(expression)			DKK1		D019324
CTD	increases(expression)			DUSP6		D019324
CTD	increases(expression)			DYNC1H1		D019324
CTD	increases(expression)			EMILIN1		D019324
CTD	increases(expression)			EMP3		D019324
CTD	increases(expression)			EPHX1		D019324
CTD	affects(binding)			ESR1		D019324
CTD	affects(binding)			ESRRA		D019324
CTD	affects(binding)			FASLG		D019324
CTD	decreases(reaction)			FASLG		D019324
CTD	increases(activity)			FASLG		D019324
CTD	increases(expression)			FBXO25		D019324
CTD	affects(reaction)			FDFT1		D019324
CTD	decreases(expression)			FDFT1		D019324
CTD	decreases(expression)			FGB		D019324
CTD	increases(expression)			FLNC		D019324
CTD	decreases(expression)			FMO1		D019324
CTD	decreases(expression)			FMO5		D019324
CTD	increases(expression)			FNDC4		D019324
CTD	affects(binding)			FOS		D019324
CTD	increases(reaction)			FOS		D019324
CTD	increases(expression)			GABARAPL1		D019324
CTD	increases(expression)			GALR2		D019324
CTD	increases(expression)			GCLC		D019324
CTD	increases(expression)			GCLM		D019324
CTD	increases(expression)			GCNT3		D019324
CTD	increases(expression)			GDF15		D019324
CTD	increases(expression)			GLA		D019324
CTD	increases(expression)			GPRC5C		D019324
CTD	decreases(expression)			GRB7		D019324
CTD	increases(expression)			GSTP1		D019324
CTD	increases(expression)			HIST1H1C		D019324
CTD	affects(reaction)			HMGCR		D019324
CTD	decreases(expression)			HMGCR		D019324
CTD	decreases(expression)			HMGCS1		D019324
CTD	increases(expression)			HMOX1		D019324
CTD	decreases(expression)			HP		D019324
CTD	decreases(expression)			HPX		D019324
CTD	decreases(expression)			HSD17B7		D019324
CTD	increases(expression)			HSPA1B		D019324
CTD	increases(expression)			HSPA5		D019324
CTD	increases(expression)			HSPB8		D019324
CTD	decreases(expression)			IDI1		D019324
CTD	decreases(expression)			IGDCC4		D019324
CTD	increases(expression)			IGFBP1		D019324
CTD	increases(expression)			IL1A		D019324
CTD	decreases(expression)			IL1B		D019324
CTD	increases(expression)			IL6		D019324
CTD	decreases(expression)			INHBB		D019324
CTD	increases(expression)			INHBE		D019324
CTD	decreases(expression)			INSL4		D019324
CTD	affects(binding)			JUN		D019324
CTD	increases(reaction)			JUN		D019324
CTD	increases(expression)			KLF6		D019324
CTD	increases(expression)			KLK14		D019324
CTD	increases(expression)			KLRG1		D019324
CTD	decreases(expression)			KRT10		D019324
CTD	increases(expression)			KYNU		D019324
CTD	increases(expression)			LAMB3		D019324
CTD	increases(expression)			LGALS3		D019324
CTD	increases(expression)			LMCD1		D019324
CTD	decreases(expression)			LOR		D019324
CTD	increases(expression)			LRRC25		D019324
CTD	affects(reaction)			LSS		D019324
CTD	decreases(expression)			LSS		D019324
CTD	increases(phosphorylation)			MAPK1		D019324
CTD	increases(phosphorylation)			MAPK3		D019324
CTD	increases(expression)			MYOF		D019324
CTD	decreases(expression)			NAV2		D019324
CTD	increases(expression)			NFE2L2		D019324
CTD	affects(binding)			NQO1		D019324
CTD	increases(reaction)			NQO1		D019324
CTD	increases(expression)			NQO1		D019324
CTD	increases(expression)			NQO1		D019324
CTD	increases(expression)			NQO2		D019324
CTD	decreases(expression)			NR1H4		D019324
CTD	affects(binding)			NR2F1		D019324
CTD	increases(expression)			NUPR1		D019324
CTD	increases(expression)			OSGIN1		D019324
CTD	decreases(expression)			PAH		D019324
CTD	increases(expression)			PC		D019324
CTD	increases(expression)			PELO		D019324
CTD	increases(expression)			PF4V1		D019324
CTD	increases(expression)			PKNOX1		D019324
CTD	increases(expression)			PSMC1		D019324
CTD	increases(expression)			PSMC2		D019324
CTD	increases(expression)			PSMC4		D019324
CTD	increases(expression)			PSMD13		D019324
CTD	increases(expression)			RASD1		D019324
CTD	increases(expression)			RGS10		D019324
CTD	increases(expression)			RGS20		D019324
CTD	increases(expression)			RIT1		D019324
CTD	decreases(expression)			SERPINA3		D019324
CTD	decreases(expression)			SERPINA4		D019324
CTD	decreases(expression)			SERPINA7		D019324
CTD	increases(expression)			SERPINE1		D019324
CTD	increases(expression)			SFN		D019324
CTD	increases(expression)			SGK2		D019324
CTD	increases(expression)			SH2D5		D019324
CTD	decreases(expression)			SLC10A1		D019324
CTD	increases(expression)			SLC16A6		D019324
CTD	increases(expression)			SLC20A1		D019324
CTD	decreases(expression)			SLC22A1		D019324
CTD	increases(expression)			SLC2A8		D019324
CTD	increases(expression)			SLC3A2		D019324
CTD	increases(expression)			SLC6A20		D019324
CTD	increases(expression)			SLC7A5		D019324
CTD	affects(reaction)			SQLE		D019324
CTD	decreases(expression)			SQLE		D019324
CTD	decreases(expression)			SRPX		D019324
CTD	increases(expression)			ST3GAL6		D019324
CTD	increases(expression)			ST6GALNAC4		D019324
CTD	increases(expression)			SULT1E1		D019324
CTD	decreases(expression)			TAGLN		D019324
CTD	increases(expression)			TALDO1		D019324
CTD	increases(expression)			TDP2		D019324
CTD	increases(expression)			TM6SF2		D019324
CTD	increases(expression)			TNFRSF12A		D019324
CTD	decreases(expression)			TNFRSF19		D019324
CTD	increases(expression)			TNNC1		D019324
CTD	affects(binding)			TP53		D019324
CTD	decreases(response to substance)			TP53		D019324
CTD	increases(activity)			TP53		D019324
CTD	increases(expression)			TP53		D019324
CTD	increases(expression)			TRPV2		D019324
CTD	decreases(expression)			TUBA1A		D019324
CTD	increases(expression)			TUBB		D019324
CTD	increases(expression)			TXNL1		D019324
CTD	increases(expression)			TXNRD1		D019324
CTD	increases(expression)			UBC		D019324
CTD	decreases(expression)			UGGT1		D019324
CTD	increases(expression)			UGT1A		D019324
CTD	affects(binding)			UGT1A1		D019324
CTD	increases(expression)			UGT1A1		D019324
CTD	increases(reaction)			UGT1A1		D019324
CTD	increases(activity)			UGT1A1		D019324
CTD	increases(activity)			UGT1A1		D019324
CTD	increases(expression)			UGT1A1		D019324
CTD	increases(expression)			UGT1A1		D019324
CTD	increases(expression)			UGT1A1		D019324
CTD	increases(expression)			UGT1A10		D019324
CTD	increases(expression)			UGT1A3		D019324
CTD	increases(expression)			UGT1A4		D019324
CTD	increases(expression)			UGT1A5		D019324
CTD	increases(glucuronidation)			UGT1A6		D019324
CTD	increases(reaction)			UGT1A6		D019324
CTD	increases(expression)			UGT1A6		D019324
CTD	increases(expression)			UGT1A7		D019324
CTD	increases(expression)			UGT1A8		D019324
CTD	increases(expression)			UGT1A9		D019324
CTD	decreases(expression)			UGT2B10		D019324
CTD	decreases(expression)			UGT2B15		D019324
CTD	increases(expression)			UGT2B15		D019324
PubChem	Potency-Replicate_1	uM	4.856	AHR	-	GI(Protien) :
PubChem	AhR Potency (uM)	uM	5.661	AHR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	13.685	CYP19A1	-	GI(Protien) :
PubChem	None	uM		CYP19A1	-	GI(Protien) :
PubChem	None	uM		EPAS1	-	GI(Protien) :
PubChem	None	uM		EPAS1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	2.434	ESR1	-	GI(Protien) :
PubChem	None	uM		HIF1A	-	GI(Protien) :
PubChem	None	uM		MC4R	-	GI(Protien) :
PubChem	None	uM		MC4R	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.831	NFE2L2	-	GI(Protien) :
PubChem	None	uM		NR0B1	-	GI(Protien) :
PubChem	AC50_uM	uM	0.260	PAX8	-	GI(Protien) :
PubChem	AC50_uM	uM	0.260	PAX8	-	GI(Protien) :
PubChem	AC50_uM	uM	5.900	PAX8	-	GI(Protien) :
PubChem	None	uM		PAX8	-	GI(Protien) :
PubChem	None	uM		TNFRSF10B	-	GI(Protien) :
PubChem	None	uM		TNFRSF10B	-	GI(Protien) :
PubChem	None	uM		TNFRSF10B	-	GI(Protien) :
ChEMBL	Activity	-		AHR	-	Target : CHEMBL3201
ChEMBL	Inhibition	-		CYP1B1	-	Target : CHEMBL4878

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