Tan Lab | DSigDB

Gene Set: D4 : CTD - Risperidone

Collection

D4 : CTD

Chemical Name

Risperidone ( From PubChem : RISPERIDONE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Approved	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
410.484 g/mol	0	6	3.5283	True

Structure

InChI

InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3

InChIKey

RAPZEAPATHNIPO-UHFFFAOYSA-N

Links

Gene (31 / 121)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(abundance)			ABCB1		D018967
CTD	affects(response to substance)			ABCB1		D018967
CTD	increases(response to substance)			ABCB1		D018967
CTD	increases(transport)			ABCB1		D018967
CTD	decreases(export)			ABCB1		D018967
CTD	decreases(reaction)			ABCB1		D018967
CTD	decreases(activity)			ABCB1		D018967
CTD	decreases(reaction)			ABCG2		D018967
CTD	increases(transport)			ABCG2		D018967
CTD	increases(uptake)			ABCG2		D018967
CTD	affects(reaction)			BDNF		D018967
CTD	increases(expression)			BDNF		D018967
CTD	increases(activity)			CASP3		D018967
CTD	increases(reaction)			CASP3		D018967
CTD	increases(activity)			CASP7		D018967
CTD	increases(reaction)			CASP7		D018967
CTD	decreases(expression)			CRH		D018967
CTD	affects(abundance)			CYP2D6		D018967
CTD	affects(abundance)			CYP2D6		D018967
CTD	affects(metabolic processing)			CYP2D6		D018967
CTD	affects(metabolic processing)			CYP2D6		D018967
CTD	affects(response to substance)			CYP2D6		D018967
CTD	decreases(hydroxylation)			CYP2D6		D018967
CTD	decreases(metabolic processing)			CYP2D6		D018967
CTD	affects(abundance)			CYP2D6		D018967
CTD	affects(abundance)			CYP2D6		D018967
CTD	affects(metabolic processing)			CYP2D6		D018967
CTD	affects(metabolic processing)			CYP2D6		D018967
CTD	affects(response to substance)			CYP2D6		D018967
CTD	increases(metabolic processing)			CYP2D6		D018967
CTD	increases(response to substance)			CYP2D6		D018967
CTD	affects(response to substance)			CYP3A4		D018967
CTD	decreases(reaction)			CYP3A4		D018967
CTD	increases(expression)			CYP3A4		D018967
CTD	increases(reaction)			CYP3A4		D018967
CTD	affects(abundance)			CYP3A5		D018967
CTD	increases(metabolic processing)			CYP3A5		D018967
CTD	affects(response to substance)			DRD2		D018967
CTD	increases(response to substance)			DRD2		D018967
CTD	increases(response to substance)			DRD2		D018967
CTD	increases(response to substance)			DRD2		D018967
CTD	affects(binding)			DRD2		D018967
CTD	decreases(activity)			DRD2		D018967
CTD	affects(binding)			DRD2		D018967
CTD	increases(response to substance)			DRD3		D018967
CTD	increases(response to substance)			DRD3		D018967
CTD	affects(expression)			FSHB		D018967
CTD	increases(expression)			HMGCR		D018967
CTD	affects(reaction)			HTR2A		D018967
CTD	increases(expression)			HTR2A		D018967
CTD	increases(response to substance)			HTR2A		D018967
CTD	affects(response to substance)			HTR2A		D018967
CTD	increases(response to substance)			HTR2A		D018967
CTD	affects(binding)			HTR2A		D018967
CTD	decreases(activity)			HTR2A		D018967
CTD	affects(binding)			HTR2A		D018967
CTD	affects(reaction)			HTR2C		D018967
CTD	increases(expression)			HTR2C		D018967
CTD	affects(response to substance)			HTR2C		D018967
CTD	increases(response to substance)			HTR2C		D018967
CTD	affects(reaction)			HTR6		D018967
CTD	increases(expression)			HTR6		D018967
CTD	affects(binding)			HTR7		D018967
CTD	decreases(activity)			HTR7		D018967
CTD	decreases(reaction)			HTR7		D018967
CTD	affects(binding)			HTR7		D018967
CTD	decreases(activity)			HTR7		D018967
CTD	affects(binding)			HTR7		D018967
CTD	decreases(activity)			HTR7		D018967
CTD	decreases(reaction)			HTR7		D018967
CTD	increases(abundance)			HTR7		D018967
CTD	affects(binding)			INHA		D018967
CTD	increases(expression)			INHA		D018967
CTD	affects(binding)			INHBB		D018967
CTD	increases(expression)			INHBB		D018967
CTD	increases(expression)			INS		D018967
CTD	decreases(reaction)			KCNH2		D018967
CTD	increases(transport)			KCNH2		D018967
CTD	affects(response to substance)			MAOA		D018967
CTD	increases(response to substance)			MAOA		D018967
CTD	decreases(reaction)			NR1I2		D018967
CTD	increases(expression)			NR1I2		D018967
CTD	increases(reaction)			NR1I2		D018967
CTD	decreases(reaction)			PRL		D018967
CTD	increases(secretion)			PRL		D018967
CTD	affects(reaction)			PRL		D018967
CTD	increases(expression)			PRL		D018967
CTD	affects(cotreatment)			PRL		D018967
CTD	increases(expression)			PRL		D018967
CTD	increases(expression)			PRL		D018967
CTD	increases(secretion)			PRL		D018967
CTD	affects(response to substance)			SNAP25		D018967
PubChem	Potency	uM	3.162	CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	7.943	CYP2D6	-	GI(Protien) :
PubChem	None	uM		CYP2D6	-	GI(Protien) :
PubChem	None	uM		DRD1	-	GI(Protien) :
PubChem	None	uM		DRD2	-	GI(Protien) :
PubChem	None	uM		DRD3	-	GI(Protien) :
PubChem	None	uM		HTR1A		GI(Protien) :
PubChem	None	uM		HTR1A		GI(Protien) :
PubChem	None	uM		HTR1B		GI(Protien) :
PubChem	None	uM		HTR1B		GI(Protien) :
PubChem	None	uM		HTR1D		GI(Protien) :
PubChem	None	uM		HTR1D		GI(Protien) :
PubChem	None	uM		HTR1E		GI(Protien) :
PubChem	None	uM		HTR1F		GI(Protien) :
PubChem	None	uM		HTR2A		GI(Protien) :
PubChem	None	uM		HTR2A		GI(Protien) :
PubChem	None	uM		HTR2A		GI(Protien) :
PubChem	None	uM		HTR2C		GI(Protien) :
PubChem	None	uM		HTR2C		GI(Protien) :
PubChem	None	uM		HTR6		GI(Protien) :
PubChem	None	uM		HTR7		GI(Protien) :
PubChem	None	uM		HTR7		GI(Protien) :
PubChem	Potency	uM	3.162	KCNH2		GI(Protien) :
PubChem	Potency	uM	3.162	KCNH2		GI(Protien) :
ChEMBL	AC50	nM	3162.280	CYP2D6	-	Target : CHEMBL289
ChEMBL	AC50	nM	7943.280	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	3162.300	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	7943.300	CYP2D6	-	Target : CHEMBL289
ChEMBL	Activity	-		DRD2	-	Target : CHEMBL217

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