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Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : CTD - alpha-Linolenic Acid

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Collection	D4 : CTD
Chemical Name	alpha-Linolenic Acid ( From PubChem : LINOLENIC ACID )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Not Not Not Approved Not Not Approved Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 278.43 g/mol 1 2 5.6605 False(3/4)
Structure
InChI	InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-
InChIKey	DTOSIQBPPRVQHS-PDBXOOCHSA-N
Links
Gene (40 / 90) ⊖ Less	Source Type Unit Value Gene PMID Assay Other CTD increases(expression) ABCB11 D017962 CTD increases(reaction) ABCB11 D017962 CTD increases(expression) CPT1A D017962 CTD decreases(activity) CYP1A2 D017962 CTD decreases(reaction) CYP24A1 D017962 CTD increases(expression) CYP24A1 D017962 CTD decreases(activity) CYP2C19 D017962 CTD affects(cotreatment) CYP2C19 D017962 CTD increases(metabolic processing) CYP2C19 D017962 CTD decreases(activity) CYP2C9 D017962 CTD affects(cotreatment) CYP2C9 D017962 CTD increases(metabolic processing) CYP2C9 D017962 CTD decreases(activity) CYP2E1 D017962 CTD decreases(activity) CYP3A4 D017962 CTD affects(cotreatment) FADS1 D017962 CTD increases(expression) FADS1 D017962 CTD affects(abundance) FADS1 D017962 CTD decreases(expression) FADS1 D017962 CTD decreases(reaction) FADS1 D017962 CTD increases(activity) GCLC D017962 CTD increases(expression) GCLC D017962 CTD increases(expression) HMOX1 D017962 CTD affects(cotreatment) IL1B D017962 CTD increases(expression) IL1B D017962 CTD affects(cotreatment) IL4 D017962 CTD decreases(expression) IL4 D017962 CTD decreases(reaction) KNG1 D017962 CTD increases(expression) KNG1 D017962 CTD affects(binding) NR1H4 D017962 CTD decreases(reaction) NR1H4 D017962 CTD increases(activity) NR1H4 D017962 CTD affects(binding) PPARA D017962 CTD increases(activity) PPARA D017962 CTD increases(expression) PPARA D017962 CTD increases(reaction) PPARA D017962 CTD affects(binding) PPARD D017962 CTD increases(activity) PPARD D017962 CTD increases(expression) PPARD D017962 CTD affects(binding) PPARG D017962 CTD increases(activity) PPARG D017962 CTD increases(activity) PPARG D017962 CTD increases(expression) PTGS2 D017962 CTD affects(binding) RXRA D017962 CTD increases(activity) RXRA D017962 CTD affects(binding) RXRA D017962 CTD increases(expression) VDR D017962 CTD affects(cotreatment) VDR D017962 PubChem Potency uM 3.548 ALDH1A1 - GI(Protien) : PubChem Potency uM 10.000 ALDH1A1 - GI(Protien) : PubChem Potency uM 22.387 ALDH1A1 - GI(Protien) : PubChem Potency uM 0.126 ALOX15 - GI(Protien) : PubChem IC50_Mean uM 15.300 ATG4B - GI(Protien) : PubChem None uM ATG4B - GI(Protien) : PubChem None uM ATG4B - GI(Protien) : PubChem Potency uM 15.849 CYP3A4 - GI(Protien) : PubChem Potency uM 17.783 EHMT2 - GI(Protien) : PubChem Potency uM 22.387 GLS - GI(Protien) : PubChem Ratio Potency (uM) uM 21.875 HSPB1 - GI(Protien) : PubChem Potency uM 10.000 KAT2A - GI(Protien) : PubChem Potency uM 28.184 MAPT - GI(Protien) : PubChem Potency-Replicate_1 uM 34.376 NFE2L2 - GI(Protien) : PubChem Potency uM 42.163 NFE2L2 - GI(Protien) : PubChem Ratio Potency (uM) uM 45.842 NFE2L2 - GI(Protien) : PubChem None uM NR3C1 - GI(Protien) : PubChem Potency uM 7.943 POLH - GI(Protien) : PubChem Potency uM 23.934 POLH - GI(Protien) : PubChem Potency uM 12.589 POLI - GI(Protien) : PubChem Potency uM 29.935 POLI - GI(Protien) : PubChem Potency uM 3.162 POLK - GI(Protien) : PubChem Potency uM 9.466 POLK GI(Protien) : PubChem Potency uM 28.184 POLK - GI(Protien) : PubChem Potency-Replicate_1 uM 43.241 PPARG - GI(Protien) : PubChem Ratio Potency (uM) uM 48.517 PPARG - GI(Protien) : PubChem Potency uM 22.387 VDR - GI(Protien) : PubChem Potency uM 25.119 VDR - GI(Protien) : PubChem Potency uM 17.783 WRN - GI(Protien) : ChEMBL Potency nM 3548.100 ALDH1A1 - Target : CHEMBL3577 ChEMBL Potency nM 10000.000 ALDH1A1 - Target : CHEMBL3577 ChEMBL Potency nM 22387.200 ALDH1A1 - Target : CHEMBL3577 ChEMBL Potency nM 125.900 ALOX15 - Target : CHEMBL2903 ChEMBL Potency nM 14125.400 ALOX15B - Target : CHEMBL2457 ChEMBL IC50 nM 15300.000 ATG4B - Target : CHEMBL1741221 ChEMBL Potency nM 15848.900 CYP3A4 - Target : CHEMBL340 ChEMBL Potency nM 17782.800 EHMT2 - Target : CHEMBL6032 ChEMBL Activity - FFAR1 - Target : CHEMBL4422 ChEMBL Potency nM 12589.300 HSD17B10 - Target : CHEMBL4159 ChEMBL Potency nM 10000.000 KAT2A - Target : CHEMBL5501 ChEMBL Potency nM 28183.800 MAPT - Target : CHEMBL1293224 ChEMBL Potency nM 1778.300 RECQL - Target : CHEMBL1293236 ChEMBL Potency nM 5011.900 TDP1 - Target : CHEMBL1075138
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