Tan Lab | DSigDB

Gene Set: D4 : CTD - Paroxetine

Collection

D4 : CTD

Chemical Name

Paroxetine ( From PubChem : PAROXETINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
329.365 g/mol	1	4	3.6553	True

Structure

InChI

InChI=1S/C19H20FNO3/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18/h1-6,9,14,17,21H,7-8,10-12H2/t14-,17-/m0/s1

InChIKey

AHOUBRCZNHFOSL-YOEHRIQHSA-N

Links

Gene (18 / 40)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(expression)			ABCC2		D017374
CTD	affects(binding)			APP		D017374
CTD	decreases(secretion)			APP		D017374
CTD	increases(activity)			CASP3		D017374
CTD	increases(cleavage)			CASP3		D017374
CTD	affects(response to substance)			CHL1		D017374
CTD	decreases(metabolic processing)			CYP2D6		D017374
CTD	increases(response to substance)			CYP2D6		D017374
CTD	increases(metabolic processing)			CYP2D6		D017374
CTD	decreases(reaction)			CYP2D6		D017374
CTD	decreases(response to substance)			CYP2D6		D017374
CTD	increases(abundance)			CYP2D6		D017374
CTD	decreases(reaction)			CYP2D6		D017374
CTD	increases(oxidation)			CYP2D6		D017374
CTD	decreases(activity)			CYP2D6		D017374
CTD	decreases(abundance)			CYP2D6		D017374
CTD	decreases(activity)			CYP2D6		D017374
CTD	decreases(activity)			CYP2D6		D017374
CTD	decreases(degradation)			CYP2D6		D017374
CTD	increases(response to substance)			CYP2D6		D017374
CTD	affects(response to substance)			HTR2A		D017374
CTD	decreases(expression)			PF4		D017374
CTD	decreases(expression)			PPBP		D017374
CTD	decreases(expression)			PTGS2		D017374
CTD	decreases(reaction)			SLC22A2		D017374
CTD	increases(uptake)			SLC22A2		D017374
CTD	affects(binding)			SLC6A4		D017374
CTD	decreases(activity)			SLC6A4		D017374
CTD	decreases(expression)			SLC6A4		D017374
CTD	decreases(expression)			STAT3		D017374
CTD	decreases(secretion)			TNF		D017374
PubChem	Potency-Replicate_1	uM	13.448	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	21.132	AR	-	GI(Protien) :
PubChem	Potency	uM	35.481	ATXN2	-	GI(Protien) :
PubChem	Potency	uM	23.778	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	2.931	MTOR	-	GI(Protien) :
PubChem	Potency	uM	9.441	TDP1	-	GI(Protien) :
PubChem	Potency	uM	16.789	TDP1	-	GI(Protien) :
ChEMBL	Potency	nM	23778.100	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	2930.900	MTOR	-	Target : CHEMBL2842

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