Tan Lab | DSigDB

Gene Set: D4 : CTD - Doxazosin

Collection

D4 : CTD

Chemical Name

Doxazosin ( From PubChem : DOXAZOSIN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Not	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
451.475 g/mol	1	10	2.3019	True

Structure

InChI

InChI=1S/C23H25N5O5/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20/h3-6,11-12,20H,7-10,13H2,1-2H3,(H2,24,25,26)/t20-/m1/s1

InChIKey

RUZYUOTYCVRMRZ-HXUWFJFHSA-N

Links

Gene (24 / 43)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(reaction)			ABCB1		D017292
CTD	increases(transport)			ABCB1		D017292
CTD	affects(binding)			ADRA1A		D017292
CTD	affects(binding)			ADRA1B		D017292
CTD	affects(binding)			ADRA1D		D017292
CTD	affects(binding)			ADRA2A		D017292
CTD	decreases(reaction)			ADRA2A		D017292
CTD	increases(activity)			ADRA2A		D017292
CTD	decreases(expression)			ADRA2A		D017292
CTD	increases(activity)			ADRA2A		D017292
CTD	increases(expression)			BAX		D017292
CTD	increases(reaction)			BAX		D017292
CTD	decreases(expression)			BCL2		D017292
CTD	decreases(reaction)			BCL2		D017292
CTD	increases(activity)			CASP3		D017292
CTD	decreases(expression)			CCNA2		D017292
CTD	increases(expression)			CDKN1A		D017292
CTD	decreases(expression)			CRP		D017292
CTD	increases(expression)			FASLG		D017292
CTD	increases(expression)			KLF10		D017292
CTD	increases(expression)			NFKBIA		D017292
CTD	increases(expression)			NPPB		D017292
CTD	decreases(expression)			PTK2		D017292
CTD	decreases(phosphorylation)			RB1		D017292
CTD	increases(expression)			REN		D017292
CTD	decreases(expression)			SERPINB5		D017292
CTD	increases(reaction)			SERPINB5		D017292
CTD	increases(expression)			SERPINB5		D017292
CTD	increases(response to substance)			SERPINB5		D017292
CTD	decreases(reaction)			SLC22A2		D017292
CTD	increases(uptake)			SLC22A2		D017292
CTD	increases(expression)			SMAD4		D017292
CTD	increases(expression)			SMAD4		D017292
CTD	increases(reaction)			SMAD4		D017292
CTD	decreases(expression)			VEGFA		D017292
CTD	decreases(reaction)			VEGFA		D017292
CTD	decreases(expression)			VEGFA		D017292
CTD	decreases(expression)			VEGFA		D017292
CTD	increases(reaction)			VEGFA		D017292
PubChem	Potency	uM	23.100	ATAD5	-	GI(Protien) :
PubChem	Potency	uM	11.668	MTOR	-	GI(Protien) :
ChEMBL	Potency	nM	23099.900	ATAD5	-	Target : CHEMBL1741209
ChEMBL	Potency	nM	11668.100	MTOR	-	Target : CHEMBL2842

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