Tan Lab | DSigDB

Gene Set: D4 : CTD - Acitretin

Collection

D4 : CTD

Chemical Name

Acitretin ( From PubChem : ACITRETIN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Approved	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
326.429 g/mol	1	3	5.167	False(3/4)

Structure

InChI

InChI=1S/C21H26O3/c1-14(8-7-9-15(2)12-21(22)23)10-11-19-16(3)13-20(24-6)18(5)17(19)4/h7-13H,1-6H3,(H,22,23)/b9-7+,11-10+,14-8+,15-12+

InChIKey

Links

Gene (23 / 31)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(expression)			BAX		D017255
CTD	decreases(expression)			BCL2		D017255
CTD	increases(activity)			CASP3		D017255
CTD	increases(activity)			CASP8		D017255
CTD	increases(activity)			CASP9		D017255
CTD	decreases(expression)			CCND1		D017255
CTD	increases(expression)			FADD		D017255
CTD	increases(expression)			FAS		D017255
CTD	increases(expression)			FASLG		D017255
CTD	decreases(expression)			MAPK1		D017255
CTD	decreases(expression)			MAPK3		D017255
CTD	increases(activity)			PARP1		D017255
CTD	decreases(expression)			STAT3		D017255
PubChem	None	uM		CYP19A1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.473	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	1.440	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	4.253	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	6.733	ESR1	-	GI(Protien) :
PubChem	Potency	uM	8.200	GMNN	-	GI(Protien) :
PubChem	Potency	uM	26.609	GMNN	-	GI(Protien) :
PubChem	Potency	uM	22.387	KAT2A	-	GI(Protien) :
PubChem	Potency	uM	25.119	KAT2A	-	GI(Protien) :
PubChem	Potency	uM	25.119	MAPT	-	GI(Protien) :
PubChem	None	uM		PLA2G7	-	GI(Protien) :
PubChem	Potency	uM	29.935	PLK1	-	GI(Protien) :
PubChem	Potency	uM	50.119	USP1	-	GI(Protien) :
PubChem	Potency	uM	44.668	VDR	-	GI(Protien) :
ChEMBL	Potency	nM	22387.200	KAT2A	-	Target : CHEMBL5501
ChEMBL	Potency	nM	25118.900	KAT2A	-	Target : CHEMBL5501
ChEMBL	Potency	nM	56234.100	KDM4A	-	Target : CHEMBL5896
ChEMBL	Potency	nM	25118.900	MAPT	-	Target : CHEMBL1293224

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