Tan Lab | DSigDB

Gene Set: D4 : CTD - Carboplatin

Collection

D4 : CTD

Chemical Name

Carboplatin ( From PubChem : CARBOPLATIN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
339.203 g/mol	2	4	0.3234	True

Structure

InChI

InChI=1S/C6H8O4.Pt/c7-4(8)6(5(9)10)2-1-3-6;/h1-3H2,(H,7,8)(H,9,10);

InChIKey

IUJRHPSJWLCXAY-UHFFFAOYSA-N

Links

Gene (48 / 78)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(response to substance)			ACVR1C		D016190
CTD	affects(response to substance)			ALDH1A1		D016190
CTD	affects(response to substance)			ALDH3A1		D016190
CTD	increases(response to substance)			ARFGEF1		D016190
CTD	decreases(expression)			BAX		D016190
CTD	increases(cleavage)			BAX		D016190
CTD	increases(expression)			BAX		D016190
CTD	decreases(expression)			BCL2		D016190
CTD	decreases(expression)			BCL2		D016190
CTD	increases(expression)			BCL2L12		D016190
CTD	decreases(response to substance)			BIRC2		D016190
CTD	decreases(activity)			BRCA1		D016190
CTD	increases(activity)			CASP3		D016190
CTD	increases(cleavage)			CASP3		D016190
CTD	increases(reaction)			CASP3		D016190
CTD	increases(expression)			CASP3		D016190
CTD	decreases(expression)			CASP9		D016190
CTD	increases(activity)			CASP9		D016190
CTD	decreases(expression)			CD274		D016190
CTD	increases(expression)			CDKN1A		D016190
CTD	increases(response to substance)			COPS5		D016190
CTD	decreases(response to substance)			DCT		D016190
CTD	affects(reaction)			DPYD		D016190
CTD	affects(response to substance)			DPYD		D016190
CTD	affects(cotreatment)			EPCAM		D016190
CTD	increases(expression)			EPCAM		D016190
CTD	affects(cotreatment)			ERBB2		D016190
CTD	decreases(response to substance)			ERBB2		D016190
CTD	increases(expression)			FAS		D016190
CTD	affects(response to substance)			GSTP1		D016190
CTD	affects(cotreatment)			KLK3		D016190
CTD	decreases(expression)			KLK3		D016190
CTD	decreases(response to substance)			MIR630		D016190
CTD	increases(response to substance)			MYC		D016190
CTD	affects(response to substance)			NBAS		D016190
CTD	affects(binding)			NFKB1		D016190
CTD	increases(activity)			NFKB1		D016190
CTD	decreases(reaction)			NFKB1		D016190
CTD	decreases(phosphorylation)			NFKBIA		D016190
CTD	affects(binding)			NFKBIA		D016190
CTD	decreases(reaction)			NFKBIA		D016190
CTD	increases(activity)			NFKBIA		D016190
CTD	increases(response to substance)			NODAL		D016190
CTD	increases(cleavage)			PARP1		D016190
CTD	affects(reaction)			PCNA		D016190
CTD	affects(response to substance)			PCNA		D016190
CTD	decreases(expression)			PDCD1LG2		D016190
CTD	increases(expression)			PMAIP1		D016190
CTD	decreases(response to substance)			PTGS2		D016190
CTD	decreases(reaction)			PTGS2		D016190
CTD	decreases(response to substance)			RBM17		D016190
CTD	decreases(activity)			RELA		D016190
CTD	decreases(localization)			RELA		D016190
CTD	affects(binding)			RELA		D016190
CTD	increases(activity)			RELA		D016190
CTD	decreases(reaction)			RELA		D016190
CTD	increases(response to substance)			SIK1		D016190
CTD	increases(response to substance)			SLC31A1		D016190
CTD	increases(uptake)			SLC31A1		D016190
CTD	increases(response to substance)			STX2		D016190
CTD	increases(response to substance)			TFAP2A		D016190
CTD	affects(cotreatment)			TOP2A		D016190
CTD	decreases(response to substance)			TOP2A		D016190
CTD	increases(expression)			TP53		D016190
CTD	affects(reaction)			TYMS		D016190
CTD	affects(response to substance)			TYMS		D016190
PubChem	Potency	uM	3.162	MAPT	-	GI(Protien) :
PubChem	Potency	uM	4.467	MAPT	-	GI(Protien) :
PubChem	Potency	uM	22.387	POLK	-	GI(Protien) :
PubChem	Potency	uM	28.184	USP1	-	GI(Protien) :
PubChem	Potency	uM	19.953	KAT2A	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	20.334	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	8.912	POLK	-	GI(Protien) :
PubChem	Potency	uM	39.811	VDR	-	GI(Protien) :
ChEMBL	Potency	nM	25118.900	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	19952.600	KAT2A	-	Target : CHEMBL5501
ChEMBL	Potency	nM	3162.300	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	4466.800	MAPT	-	Target : CHEMBL1293224

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