Tan Lab | DSigDB

Gene Set: D4 : CTD - Gemfibrozil

Collection

D4 : CTD

Chemical Name

Gemfibrozil ( From PubChem : GEMFIBROZIL )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Approved	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
250.333 g/mol	1	3	3.5732	True

Structure

InChI

InChI=1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)

InChIKey

HEMJJKBWTPKOJG-UHFFFAOYSA-N

Links

Gene (33 / 80)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(expression)			ABCA1		D015248
CTD	decreases(reaction)			ABCC4		D015248
CTD	decreases(uptake)			ABCC4		D015248
CTD	increases(expression)			ABCC4		D015248
CTD	decreases(activity)			AKR1B10		D015248
CTD	increases(reaction)			APOA1		D015248
CTD	increases(secretion)			APOA1		D015248
CTD	increases(expression)			APOA1		D015248
CTD	decreases(expression)			APOB		D015248
CTD	affects(cotreatment)			CEBPB		D015248
CTD	decreases(reaction)			CEBPB		D015248
CTD	increases(activity)			CEBPB		D015248
CTD	affects(cotreatment)			CYP2C8		D015248
CTD	decreases(activity)			CYP2C8		D015248
CTD	affects(metabolic processing)			CYP2C8		D015248
CTD	decreases(reaction)			CYP2C8		D015248
CTD	decreases(activity)			CYP2C8		D015248
CTD	affects(chemical synthesis)			CYP2C8		D015248
CTD	decreases(activity)			CYP2C8		D015248
CTD	decreases(chemical synthesis)			CYP2C8		D015248
CTD	decreases(expression)			CYP2C8		D015248
CTD	increases(expression)			CYP2C8		D015248
CTD	increases(activity)			CYP3A4		D015248
CTD	increases(expression)			CYP3A4		D015248
CTD	decreases(expression)			CYP7A1		D015248
CTD	affects(cotreatment)			IFNG		D015248
CTD	decreases(activity)			IFNG		D015248
CTD	decreases(reaction)			IFNG		D015248
CTD	increases(abundance)			IFNG		D015248
CTD	increases(activity)			IFNG		D015248
CTD	increases(expression)			IFNG		D015248
CTD	affects(cotreatment)			IL1B		D015248
CTD	decreases(activity)			IL1B		D015248
CTD	decreases(reaction)			IL1B		D015248
CTD	increases(abundance)			IL1B		D015248
CTD	increases(activity)			IL1B		D015248
CTD	increases(expression)			IL1B		D015248
CTD	increases(activity)			LPL		D015248
CTD	affects(cotreatment)			NOS2		D015248
CTD	decreases(reaction)			NOS2		D015248
CTD	increases(expression)			NOS2		D015248
CTD	increases(expression)			NR1H2		D015248
CTD	increases(expression)			NR1H3		D015248
CTD	affects(reaction)			NR1H3		D015248
CTD	affects(response to substance)			NR1H3		D015248
CTD	affects(binding)			PPARA		D015248
CTD	increases(activity)			PPARA		D015248
CTD	affects(cotreatment)			PPARA		D015248
CTD	decreases(activity)			PPARA		D015248
CTD	decreases(reaction)			PPARA		D015248
CTD	increases(activity)			PPARA		D015248
CTD	increases(expression)			PPARA		D015248
CTD	affects(reaction)			PPARA		D015248
CTD	increases(expression)			PPARD		D015248
CTD	increases(expression)			PPARG		D015248
CTD	decreases(expression)			SERPINE1		D015248
CTD	decreases(secretion)			SERPINE1		D015248
CTD	increases(activity)			SERPINE1		D015248
CTD	decreases(reaction)			SLCO1B1		D015248
CTD	increases(uptake)			SLCO1B1		D015248
CTD	increases(expression)			UGT1A1		D015248
PubChem	Potency-Replicate_1	uM	48.904	AHR	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	6.310	CYP2C9	-	GI(Protien) :
PubChem	None	uM		CYP2C9	-	GI(Protien) :
PubChem	None	uM		NR1H2	-	GI(Protien) :
PubChem	None	uM		NR2F1	-	GI(Protien) :
PubChem	None	uM		NR5A1	-	GI(Protien) :
PubChem	None	uM		NR5A1	-	GI(Protien) :
PubChem	None	uM		NR5A2	-	GI(Protien) :
PubChem	None	uM		RARA	-	GI(Protien) :
PubChem	None	uM		RARA	-	GI(Protien) :
PubChem	None	uM		RARB	-	GI(Protien) :
PubChem	None	uM		RARG	-	GI(Protien) :
PubChem	None	uM		RORA	-	GI(Protien) :
PubChem	None	uM		RXRA	-	GI(Protien) :
ChEMBL	AC50	nM	6309.570	CYP2C9	-	Target : CHEMBL3397
ChEMBL	Potency	nM	6309.600	CYP2C9	-	Target : CHEMBL3397
ChEMBL	Activity	-		JUN	-	Target : CHEMBL4977
ChEMBL	Activity	-		PPARA	-	Target : CHEMBL239

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