Tan Lab | DSigDB

Gene Set: D4 : CTD - Ofloxacin

Collection

D4 : CTD

Chemical Name

Ofloxacin ( From PubChem : OFLOXACIN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Approved	Approved	Approved	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
361.367 g/mol	1	7	1.5469	True

Structure

InChI

InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)/t10-/m1/s1

InChIKey

GSDSWSVVBLHKDQ-SNVBAGLBSA-N

Links

Gene (24 / 43)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(reaction)			ABCB11		D015242
CTD	increases(transport)			ABCB11		D015242
CTD	decreases(activity)			ABCB11		D015242
CTD	increases(expression)			ASAH1		D015242
CTD	increases(expression)			C10ORF10		D015242
CTD	affects(cotreatment)			CYP1A2		D015242
CTD	decreases(reaction)			CYP1A2		D015242
CTD	increases(metabolic processing)			CYP1A2		D015242
CTD	affects(cotreatment)			CYP3A4		D015242
CTD	decreases(reaction)			CYP3A4		D015242
CTD	increases(metabolic processing)			CYP3A4		D015242
CTD	decreases(reaction)			IL1B		D015242
CTD	increases(expression)			IL1B		D015242
CTD	decreases(expression)			ITGB4		D015242
CTD	decreases(reaction)			MMP13		D015242
CTD	increases(expression)			MMP13		D015242
CTD	decreases(expression)			MMP13		D015242
CTD	increases(expression)			NUPR1		D015242
CTD	decreases(expression)			PHYH		D015242
CTD	decreases(reaction)			SLC22A5		D015242
CTD	increases(uptake)			SLC22A5		D015242
CTD	affects(localization)			SLC2A1		D015242
CTD	decreases(expression)			SLC2A1		D015242
CTD	increases(glucuronidation)			UGT1A1		D015242
CTD	increases(glucuronidation)			UGT1A3		D015242
CTD	increases(glucuronidation)			UGT1A7		D015242
CTD	increases(glucuronidation)			UGT1A9		D015242
PubChem	None	uM		DRD3	-	GI(Protien) :
PubChem	None	uM		KLK7	-	GI(Protien) :
PubChem	None	uM		KLK7	-	GI(Protien) :
PubChem	None	uM		SLC5A7	-	GI(Protien) :
PubChem	None	uM		SLC5A7	-	GI(Protien) :
PubChem	None	uM		SLC5A7	-	GI(Protien) :
PubChem	Potency	uM	12.995	TDP1	-	GI(Protien) :
PubChem	Potency	uM	20.596	TDP1	-	GI(Protien) :
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2C19	-	Target : CHEMBL3622
ChEMBL	Inhibition	-		CYP2C9	-	Target : CHEMBL3397
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	10000.000	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	25118.900	HSD17B10	-	Target : CHEMBL4159

Download gene sets

gmt, text, Detailed text