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Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : CTD - 9,10-Dimethyl-1,2-benzanthracene

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Collection	D4 : CTD
Chemical Name	9,10-Dimethyl-1,2-benzanthracene ( From PubChem : DMBA )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Not Not Not Not Not Not Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 256.341 g/mol 0 0 5.763 False(3/4)
Structure
InChI	InChI=1S/C20H16/c1-13-16-8-5-6-9-17(16)14(2)20-18(13)12-11-15-7-3-4-10-19(15)20/h3-12H,1-2H3
InChIKey	ARSRBNBHOADGJU-UHFFFAOYSA-N
Links
Gene (74 / 201) ⊖ Less	Source Type Unit Value Gene PMID Assay Other CTD increases(expression) ABHD3 D015127 CTD increases(expression) AHR D015127 CTD increases(reaction) AHR D015127 CTD increases(activity) AHR D015127 CTD affects(reaction) AHR D015127 CTD decreases(expression) AHR D015127 CTD affects(binding) AHR D015127 CTD decreases(reaction) AHR D015127 CTD increases(reaction) AHR D015127 CTD decreases(reaction) AHR D015127 CTD affects(activity) AKR7A2 D015127 CTD increases(reduction) AKR7A2 D015127 CTD affects(binding) AR D015127 CTD decreases(activity) AR D015127 CTD decreases(reaction) AR D015127 CTD increases(activity) AR D015127 CTD increases(expression) ARHGDIB D015127 CTD increases(expression) AXL D015127 CTD increases(expression) BAX D015127 CTD decreases(reaction) BAX D015127 CTD affects(response to substance) BRCA1 D015127 CTD increases(expression) CCL5 D015127 CTD increases(reaction) CCL5 D015127 CTD increases(expression) CDKN1A D015127 CTD increases(expression) CRABP2 D015127 CTD decreases(reaction) CYP1A1 D015127 CTD increases(activity) CYP1A1 D015127 CTD increases(expression) CYP1A1 D015127 CTD decreases(reaction) CYP1A1 D015127 CTD increases(expression) CYP1A1 D015127 CTD decreases(reaction) CYP1A1 D015127 CTD increases(activity) CYP1A1 D015127 CTD increases(expression) CYP1A1 D015127 CTD decreases(reaction) CYP1A1 D015127 CTD increases(expression) CYP1A1 D015127 CTD decreases(reaction) CYP1A1 D015127 CTD increases(expression) CYP1A1 D015127 CTD increases(activity) CYP1A1 D015127 CTD increases(expression) CYP1A1 D015127 CTD increases(expression) CYP1A1 D015127 CTD affects(binding) CYP1A1 D015127 CTD decreases(reaction) CYP1A1 D015127 CTD increases(reaction) CYP1A1 D015127 CTD increases(activity) CYP1A1 D015127 CTD increases(expression) CYP1A1 D015127 CTD affects(cotreatment) CYP1A1 D015127 CTD increases(metabolic processing) CYP1A1 D015127 CTD increases(response to substance) CYP1A1 D015127 CTD decreases(reaction) CYP1A1 D015127 CTD increases(activity) CYP1A1 D015127 CTD increases(expression) CYP1A1 D015127 CTD increases(reaction) CYP1A1 D015127 CTD decreases(reaction) CYP1A1 D015127 CTD increases(expression) CYP1A1 D015127 CTD increases(activity) CYP1A1 D015127 CTD increases(metabolic processing) CYP1A1 D015127 CTD decreases(reaction) CYP1A1 D015127 CTD increases(expression) CYP1A1 D015127 CTD increases(chemical synthesis) CYP1A1 D015127 CTD increases(metabolic processing) CYP1A1 D015127 CTD increases(reaction) CYP1A1 D015127 CTD decreases(reaction) CYP1A2 D015127 CTD increases(expression) CYP1A2 D015127 CTD decreases(reaction) CYP1A2 D015127 CTD increases(activity) CYP1A2 D015127 CTD increases(expression) CYP1A2 D015127 CTD increases(expression) CYP1A2 D015127 CTD affects(cotreatment) CYP1A2 D015127 CTD increases(metabolic processing) CYP1A2 D015127 CTD increases(reaction) CYP1A2 D015127 CTD decreases(reaction) CYP1B1 D015127 CTD increases(expression) CYP1B1 D015127 CTD decreases(reaction) CYP1B1 D015127 CTD increases(expression) CYP1B1 D015127 CTD decreases(reaction) CYP1B1 D015127 CTD increases(activity) CYP1B1 D015127 CTD increases(expression) CYP1B1 D015127 CTD decreases(reaction) CYP1B1 D015127 CTD increases(expression) CYP1B1 D015127 CTD increases(expression) CYP1B1 D015127 CTD increases(chemical synthesis) CYP1B1 D015127 CTD increases(expression) CYP1B1 D015127 CTD increases(metabolic processing) CYP1B1 D015127 CTD increases(reaction) CYP1B1 D015127 CTD decreases(reaction) CYP1B1 D015127 CTD increases(expression) CYP1B1 D015127 CTD increases(activity) CYP1B1 D015127 CTD increases(metabolic processing) CYP1B1 D015127 CTD increases(response to substance) CYP2C9 D015127 CTD increases(response to substance) CYP2D6 D015127 CTD affects(cotreatment) CYP2S1 D015127 CTD increases(oxidation) CYP2S1 D015127 CTD increases(response to substance) CYP3A4 D015127 CTD decreases(expression) DAZL D015127 CTD affects(reaction) DAZL D015127 CTD decreases(reaction) DAZL D015127 CTD decreases(expression) DDX4 D015127 CTD affects(reaction) DDX4 D015127 CTD decreases(reaction) DDX4 D015127 CTD increases(expression) DPYSL4 D015127 CTD increases(expression) EMP1 D015127 CTD increases(expression) EMP3 D015127 CTD increases(metabolic processing) EPHX1 D015127 CTD increases(reaction) EPHX1 D015127 CTD decreases(expression) EPO D015127 CTD increases(expression) FLNC D015127 CTD decreases(expression) GAPDH D015127 CTD increases(expression) GLS D015127 CTD increases(activity) HIF1A D015127 CTD affects(reaction) HRAS D015127 CTD increases(response to substance) HRAS D015127 CTD increases(response to substance) HRAS D015127 CTD increases(expression) IER5 D015127 CTD increases(expression) ISG15 D015127 CTD increases(expression) KIF1A D015127 CTD increases(expression) KRT80 D015127 CTD increases(expression) LAMC2 D015127 CTD increases(expression) LGALS7 D015127 CTD affects(cotreatment) MGMT D015127 CTD decreases(response to substance) MGMT D015127 CTD increases(expression) MR1 D015127 CTD increases(expression) NETO2 D015127 CTD increases(expression) PFKM D015127 CTD increases(expression) PLAU D015127 CTD decreases(expression) PPP2R1B D015127 CTD decreases(expression) PRDM1 D015127 CTD affects(reaction) PRDM1 D015127 CTD decreases(reaction) PRDM1 D015127 CTD increases(expression) PROCR D015127 CTD increases(expression) RIPPLY3 D015127 CTD increases(expression) RRM2B D015127 CTD increases(expression) SFN D015127 CTD affects(binding) SOD2 D015127 CTD affects(cotreatment) SOD2 D015127 CTD decreases(reaction) SOD2 D015127 CTD increases(activity) SOD2 D015127 CTD affects(binding) SOD2 D015127 CTD affects(cotreatment) SOD2 D015127 CTD decreases(expression) SOD2 D015127 CTD decreases(reaction) SOD2 D015127 CTD increases(activity) SOD2 D015127 CTD affects(binding) SP1 D015127 CTD affects(cotreatment) SP1 D015127 CTD decreases(reaction) SP1 D015127 CTD increases(activity) SP1 D015127 CTD decreases(expression) SP1 D015127 CTD increases(expression) STMN3 D015127 CTD increases(expression) TNFRSF14 D015127 CTD increases(expression) TNFSF9 D015127 CTD increases(activity) TP53 D015127 CTD affects(binding) TP53 D015127 CTD affects(cotreatment) TP53 D015127 CTD decreases(reaction) TP53 D015127 CTD increases(activity) TP53 D015127 CTD decreases(expression) TP53 D015127 CTD increases(expression) TUBA4A D015127 CTD increases(expression) VEGFA D015127 PubChem Potency-Replicate_1 uM 8.547 AHR - GI(Protien) : PubChem AhR Potency (uM) uM 9.776 AHR - GI(Protien) : PubChem AhR Potency (uM) uM 15.956 AHR - GI(Protien) : PubChem Potency-Replicate_1 uM 21.690 AHR - GI(Protien) : PubChem Potency uM 25.119 AHR - GI(Protien) : PubChem None uM APLNR - GI(Protien) : PubChem Potency-Replicate_1 uM 30.638 AR - GI(Protien) : PubChem Potency uM 18.349 ATAD5 - GI(Protien) : PubChem Potency-Replicate_1 uM 27.306 CYP19A1 - GI(Protien) : PubChem None uM CYP19A1 - GI(Protien) : PubChem None uM DRD2 - GI(Protien) : PubChem Potency-Replicate_1 uM 0.068 ESR1 - GI(Protien) : PubChem ER Potency (uM) uM 0.486 ESR1 - GI(Protien) : PubChem Potency-Replicate_1 uM 0.486 ESR1 - GI(Protien) : PubChem Potency uM 4.467 ESR1 - GI(Protien) : PubChem Potency uM 15.849 ESR1 - GI(Protien) : PubChem Potency-Replicate_1 uM 30.327 ESR1 - GI(Protien) : PubChem ER Potency (uM) uM ESR1 - GI(Protien) : PubChem Potency uM 1.836 GMNN - GI(Protien) : PubChem Potency uM 44.668 HIF1A - GI(Protien) : PubChem Ratio Potency (uM) uM 47.548 HSPB1 - GI(Protien) : PubChem Ratio Potency (uM) uM 50.882 HSPB1 - GI(Protien) : PubChem None uM MDM2 - GI(Protien) : PubChem None uM MDM2 - GI(Protien) : PubChem None uM MDM4 - GI(Protien) : PubChem None uM MDM4 - GI(Protien) : PubChem Ratio Potency (uM) uM 6.859 NFE2L2 - GI(Protien) : PubChem Ratio Potency (uM) uM 7.473 NFE2L2 - GI(Protien) : PubChem Potency uM 10.591 NFE2L2 - GI(Protien) : PubChem Potency uM 24.337 NFE2L2 - GI(Protien) : PubChem None uM NLRP3 - GI(Protien) : PubChem None uM NLRP3 - GI(Protien) : PubChem Potency-Replicate_1 uM 48.469 NR1H4 - GI(Protien) : PubChem Potency-Replicate_1 uM 39.811 NR1I2 - GI(Protien) : PubChem Potency-Replicate_1 uM 3.850 NR3C1 - GI(Protien) : PubChem Ratio Potency (uM) uM 28.871 NR3C1 - GI(Protien) : PubChem Ratio Potency (uM) uM 48.966 NR3C1 - GI(Protien) : PubChem None uM OPRD1 - GI(Protien) : PubChem None uM OPRM1 - GI(Protien) : PubChem Ratio Potency (uM) uM 11.168 PPARG - GI(Protien) : PubChem Potency uM 8.912 RXRA - GI(Protien) : ChEMBL Potency nM 18348.900 ATAD5 - Target : CHEMBL1741209 ChEMBL Potency nM 44668.400 HIF1A - Target : CHEMBL4261 ChEMBL Potency nM 25118.900 HSD17B10 - Target : CHEMBL4159
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