Tan Lab | DSigDB

Gene Set: D4 : CTD - Zearalenone

Collection

D4 : CTD

Chemical Name

Zearalenone ( From PubChem : ZEARALENONE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
318.364 g/mol	2	5	3.5796	True

Structure

InChI

InChI=1S/C18H22O5/c1-12-6-5-9-14(19)8-4-2-3-7-13-10-15(20)11-16(21)17(13)18(22)23-12/h3,7,10-12,20-21H,2,4-6,8-9H2,1H3/b7-3+/t12-/m0/s1

InChIKey

MBMQEIFVQACCCH-QBODLPLBSA-N

Links

Gene (184 / 267)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(transport)			ABCC1		D015025
CTD	decreases(reaction)			ABCC1		D015025
CTD	increases(expression)			ABCC1		D015025
CTD	increases(transport)			ABCC2		D015025
CTD	decreases(reaction)			ABCC2		D015025
CTD	increases(expression)			ABCC2		D015025
CTD	decreases(reaction)			ABCC3		D015025
CTD	increases(transport)			ABCC3		D015025
CTD	decreases(expression)			ABCC3		D015025
CTD	increases(expression)			ABCG2		D015025
CTD	decreases(expression)			ACKR2		D015025
CTD	increases(expression)			ADAMTS9		D015025
CTD	affects(binding)			ALPL		D015025
CTD	decreases(reaction)			ALPL		D015025
CTD	increases(activity)			ALPL		D015025
CTD	increases(expression)			ALPPL2		D015025
CTD	increases(expression)			ANAPC1		D015025
CTD	increases(expression)			ANO1		D015025
CTD	decreases(expression)			APOE		D015025
CTD	decreases(reaction)			AR		D015025
CTD	increases(activity)			AR		D015025
CTD	affects(binding)			AR		D015025
CTD	decreases(reaction)			AR		D015025
CTD	increases(activity)			AR		D015025
CTD	decreases(expression)			ASAH1		D015025
CTD	increases(expression)			ASRGL1		D015025
CTD	decreases(expression)			ATPAF1		D015025
CTD	affects(localization)			BAX		D015025
CTD	decreases(expression)			BDNF		D015025
CTD	increases(expression)			BICD1		D015025
CTD	increases(expression)			BNIP1		D015025
CTD	increases(expression)			C22ORF29		D015025
CTD	decreases(expression)			C6ORF48		D015025
CTD	increases(expression)			CA2		D015025
CTD	increases(expression)			CABLES1		D015025
CTD	increases(expression)			CAPN9		D015025
CTD	increases(expression)			CARS		D015025
CTD	increases(activity)			CASP3		D015025
CTD	increases(expression)			CBFA2T3		D015025
CTD	increases(expression)			CEBPD		D015025
CTD	decreases(reaction)			CGA		D015025
CTD	increases(expression)			CGA		D015025
CTD	increases(expression)			CGB		D015025
CTD	increases(expression)			CHAC2		D015025
CTD	decreases(expression)			CNFN		D015025
CTD	increases(expression)			CORO1C		D015025
CTD	decreases(expression)			CUTA		D015025
CTD	decreases(expression)			CUX1		D015025
CTD	affects(localization)			CYCS		D015025
CTD	decreases(activity)			CYP19A1		D015025
CTD	decreases(reaction)			CYP1A1		D015025
CTD	increases(activity)			CYP1A1		D015025
CTD	increases(expression)			CYP1A1		D015025
CTD	decreases(activity)			CYP1A1		D015025
CTD	decreases(expression)			CYP1A1		D015025
CTD	increases(hydroxylation)			CYP1A2		D015025
CTD	increases(chemical synthesis)			CYP1A2		D015025
CTD	increases(activity)			CYP1B1		D015025
CTD	increases(reaction)			CYP1B1		D015025
CTD	increases(expression)			CYP3A4		D015025
CTD	decreases(expression)			DDC		D015025
CTD	increases(expression)			DHRS3		D015025
CTD	increases(expression)			DOK4		D015025
CTD	decreases(expression)			ECH1		D015025
CTD	increases(expression)			EPB41L2		D015025
CTD	decreases(expression)			EPN3		D015025
CTD	decreases(expression)			ERBB3		D015025
CTD	increases(expression)			ERCC3		D015025
CTD	decreases(expression)			ERP27		D015025
CTD	increases(expression)			ESPN		D015025
CTD	affects(binding)			ESR1		D015025
CTD	decreases(reaction)			ESR1		D015025
CTD	increases(activity)			ESR1		D015025
CTD	affects(binding)			ESR1		D015025
CTD	decreases(activity)			ESR1		D015025
CTD	affects(binding)			ESR1		D015025
CTD	increases(activity)			ESR1		D015025
CTD	affects(binding)			ESR1		D015025
CTD	affects(binding)			ESR1		D015025
CTD	increases(reaction)			ESR1		D015025
CTD	increases(reaction)			ESR1		D015025
CTD	increases(activity)			ESR1		D015025
CTD	affects(binding)			ESR2		D015025
CTD	decreases(activity)			ESR2		D015025
CTD	affects(binding)			ESR2		D015025
CTD	increases(activity)			ESR2		D015025
CTD	affects(binding)			ESR2		D015025
CTD	increases(expression)			ETNK2		D015025
CTD	decreases(expression)			FAM107A		D015025
CTD	decreases(expression)			FAM129B		D015025
CTD	decreases(expression)			FNDC5		D015025
CTD	decreases(expression)			FOLR1		D015025
CTD	increases(expression)			FOXD1		D015025
CTD	decreases(expression)			FOXJ1		D015025
CTD	increases(expression)			G0S2		D015025
CTD	increases(expression)			GALNT4		D015025
CTD	decreases(expression)			GALR2		D015025
CTD	increases(expression)			GDPD5		D015025
CTD	decreases(expression)			GINS3		D015025
CTD	increases(expression)			GLRX2		D015025
CTD	affects(binding)			GPER1		D015025
CTD	increases(expression)			GPR142		D015025
CTD	increases(expression)			GREB1		D015025
CTD	decreases(expression)			GSDMD		D015025
CTD	decreases(expression)			HAPLN3		D015025
CTD	increases(expression)			HES2		D015025
CTD	decreases(expression)			HIST1H2BD		D015025
CTD	increases(expression)			HIVEP1		D015025
CTD	decreases(expression)			HMGN2		D015025
CTD	decreases(expression)			HSD17B14		D015025
CTD	increases(expression)			HSPA1A		D015025
CTD	increases(expression)			HSPB1		D015025
CTD	decreases(expression)			IFITM3		D015025
CTD	decreases(expression)			IGFBP6		D015025
CTD	increases(expression)			IL4R		D015025
CTD	increases(expression)			IMPDH2		D015025
CTD	increases(expression)			IPO13		D015025
CTD	increases(expression)			ITPK1		D015025
CTD	increases(expression)			KCNF1		D015025
CTD	increases(expression)			KCNJ5		D015025
CTD	increases(expression)			KCTD20		D015025
CTD	decreases(expression)			KIAA0101		D015025
CTD	decreases(expression)			KRT17		D015025
CTD	decreases(expression)			LEFTY2		D015025
CTD	decreases(expression)			LGALS1		D015025
CTD	increases(expression)			LPPR2		D015025
CTD	increases(expression)			MAK16		D015025
CTD	decreases(expression)			MAPK13		D015025
CTD	decreases(expression)			MDK		D015025
CTD	decreases(expression)			MEOX1		D015025
CTD	increases(expression)			MET		D015025
CTD	decreases(expression)			MFGE8		D015025
CTD	increases(expression)			MFN2		D015025
CTD	increases(expression)			MLPH		D015025
CTD	increases(expression)			MSMB		D015025
CTD	increases(expression)			MUC5AC		D015025
CTD	increases(secretion)			MUC5AC		D015025
CTD	increases(expression)			MUC5B		D015025
CTD	increases(secretion)			MUC5B		D015025
CTD	increases(expression)			NCMAP		D015025
CTD	affects(binding)			NCOA2		D015025
CTD	increases(reaction)			NCOA2		D015025
CTD	increases(expression)			NEIL2		D015025
CTD	decreases(expression)			NGEF		D015025
CTD	increases(activity)			NR1I2		D015025
CTD	increases(expression)			NRIP1		D015025
CTD	increases(expression)			NRTN		D015025
CTD	increases(expression)			OLFM1		D015025
CTD	increases(expression)			OLFML3		D015025
CTD	increases(expression)			PDCD7		D015025
CTD	decreases(expression)			PFKFB2		D015025
CTD	decreases(reaction)			PGR		D015025
CTD	increases(expression)			PGR		D015025
CTD	affects(binding)			PGR		D015025
CTD	increases(activity)			PGR		D015025
CTD	increases(expression)			PGR		D015025
CTD	decreases(expression)			PHF11		D015025
CTD	increases(expression)			PIM1		D015025
CTD	increases(expression)			PLCB1		D015025
CTD	increases(expression)			PLXDC2		D015025
CTD	increases(expression)			POLR2C		D015025
CTD	increases(expression)			PRDM14		D015025
CTD	increases(expression)			PRKAR2A		D015025
CTD	increases(expression)			PRSS23		D015025
CTD	decreases(expression)			RAB20		D015025
CTD	increases(expression)			RBM24		D015025
CTD	decreases(expression)			RBP1		D015025
CTD	decreases(expression)			RIBC2		D015025
CTD	decreases(expression)			RMI2		D015025
CTD	decreases(expression)			RRAGB		D015025
CTD	increases(expression)			S1PR3		D015025
CTD	decreases(expression)			SAT1		D015025
CTD	increases(expression)			SCAND2P		D015025
CTD	increases(expression)			SF3B5		D015025
CTD	decreases(expression)			SIAH1		D015025
CTD	increases(expression)			SLC1A5		D015025
CTD	increases(expression)			SLC31A1		D015025
CTD	increases(expression)			SLC3A2		D015025
CTD	decreases(expression)			SLC41A3		D015025
CTD	increases(expression)			SLC6A6		D015025
CTD	increases(expression)			SLC7A5		D015025
CTD	decreases(expression)			SPSB3		D015025
CTD	decreases(expression)			SQLE		D015025
CTD	decreases(expression)			SSC4D		D015025
CTD	decreases(activity)			SULT1E1		D015025
CTD	increases(expression)			TGFA		D015025
CTD	decreases(expression)			TH		D015025
CTD	increases(expression)			THBS1		D015025
CTD	decreases(expression)			TINF2		D015025
CTD	decreases(expression)			TMEM121		D015025
CTD	decreases(expression)			TMEM54		D015025
CTD	decreases(expression)			TNFRSF25		D015025
CTD	decreases(expression)			TNNT1		D015025
CTD	decreases(expression)			TSC22D1		D015025
CTD	increases(expression)			TSKU		D015025
CTD	decreases(expression)			TSPAN10		D015025
CTD	decreases(expression)			TSPAN12		D015025
CTD	increases(glucuronidation)			UGT1A1		D015025
CTD	increases(glucuronidation)			UGT1A10		D015025
CTD	increases(glucuronidation)			UGT1A7		D015025
CTD	increases(glucuronidation)			UGT1A8		D015025
CTD	increases(glucuronidation)			UGT1A9		D015025
CTD	increases(expression)			UTP15		D015025
CTD	decreases(expression)			VCPKMT		D015025
CTD	decreases(expression)			WNT7A		D015025
CTD	decreases(expression)			WWP2		D015025
CTD	increases(expression)			ZKSCAN2		D015025
CTD	increases(expression)			ZMYM3		D015025
CTD	decreases(expression)			ZMYND10		D015025
PubChem	Potency	uM	14.125	ALDH1A1	-	GI(Protien) :
PubChem	Potency	uM	14.989	ALDH1A1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	19.399	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	20.158	AR	-	GI(Protien) :
PubChem	Potency	uM	44.668	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	52.473	AR	-	GI(Protien) :
PubChem	Potency	uM	20.596	ATAD5	-	GI(Protien) :
PubChem	None	uM		CFTR	-	GI(Protien) :
PubChem	None	uM		CFTR	-	GI(Protien) :
PubChem	IC50_CF-PAF_Mean	uM		CFTR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	23.439	CYP19A1	-	GI(Protien) :
PubChem	None	uM		CYP2C19	-	GI(Protien) :
PubChem	None	uM		CYP2C9	-	GI(Protien) :
PubChem	Potency	uM	0.316	CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	0.398	CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	0.010	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.013	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.071	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.128	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.148	ESR1	-	GI(Protien) :
PubChem	Potency	uM	14.125	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	14.145	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	22.419	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	47.200	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	47.200	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM		ESR1	-	GI(Protien) :
PubChem	None	uM		GSK3A	-	GI(Protien) :
PubChem	EC50_uM	uM	5.449	GSK3B	-	GI(Protien) :
PubChem	Potency	uM	11.220	HPGD	-	GI(Protien) :
PubChem	Potency	uM	14.125	HPGD	-	GI(Protien) :
PubChem	IC50	uM	2.402	HSP90AA1	-	GI(Protien) :
PubChem	None	uM		HSP90AA1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	14.091	HSPB1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	14.271	HSPB1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	15.409	HSPB1	-	GI(Protien) :
PubChem	Potency	uM	35.481	NR1H4	-	GI(Protien) :
PubChem	Potency	uM	39.811	NR1H4	-	GI(Protien) :
PubChem	None	uM		NR1H4	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	11.220	NR1I2	-	GI(Protien) :
PubChem	Potency	uM	44.668	NR3C1	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :
PubChem	None	uM		PPARG	-	GI(Protien) :
PubChem	IC50	uM	6.922	PTK2B	-	GI(Protien) :
PubChem	None	uM		RGS4	-	GI(Protien) :
PubChem	None	uM		RGS4	-	GI(Protien) :
PubChem	EC50_uM	uM	44.560	STK33	-	GI(Protien) :
PubChem	None	uM		STK33	-	GI(Protien) :
PubChem	None	uM		STK33	-	GI(Protien) :
ChEMBL	Potency	nM	14988.900	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	14125.400	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	20596.200	ATAD5	-	Target : CHEMBL1741209
ChEMBL	Potency	nM	316.200	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	398.100	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	14125.400	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	11220.200	HPGD	-	Target : CHEMBL1293255
ChEMBL	IC50	nM	2402.000	HSP90AA1	-	Target : CHEMBL2095165
ChEMBL	IC50	nM	2402.000	HSP90AB1	-	Target : CHEMBL2095165
ChEMBL	IC50	nM	6922.000	PTK2B	-	Target : CHEMBL5469

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