Tan Lab | DSigDB

Gene Set: D4 : CTD - Trifluridine

Collection

D4 : CTD

Chemical Name

Trifluridine ( From PubChem : TRIFLURIDINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
296.2 g/mol	3	6	-0.8039	True

Structure

InChI

InChI=1S/C10H11F3N2O5/c11-10(12,13)4-2-15(9(19)14-8(4)18)7-1-5(17)6(3-16)20-7/h2,5-7,16-17H,1,3H2,(H,14,18,19)/t5-,6+,7+/m0/s1

InChIKey

Links

Gene (16 / 25)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(reaction)			CASP3		D014271
CTD	increases(cleavage)			CASP3		D014271
CTD	increases(activity)			CASP3		D014271
CTD	increases(cleavage)			CASP8		D014271
CTD	increases(cleavage)			CASP9		D014271
CTD	decreases(reaction)			CTSB		D014271
CTD	increases(cleavage)			CTSB		D014271
CTD	increases(cleavage)			PARP1		D014271
PubChem	None	uM		APP	-	GI(Protien) :
PubChem	None	uM		DRD3	-	GI(Protien) :
PubChem	None	uM		DRD3	-	GI(Protien) :
PubChem	None	uM		JAK2	-	GI(Protien) :
PubChem	None	uM		MAP1LC3A	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	None	uM		NCOA1	-	GI(Protien) :
PubChem	None	uM		NCOA3	-	GI(Protien) :
PubChem	None	uM		NFKB1	-	GI(Protien) :
PubChem	None	uM		RELA	-	GI(Protien) :
PubChem	Potency	uM	0.130	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.164	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.168	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.335	TDP1	-	GI(Protien) :

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