Tan Lab | DSigDB

Gene Set: D4 : CTD - Triamterene

Collection

D4 : CTD

Chemical Name

Triamterene ( From PubChem : TRIAMTERENE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
253.263 g/mol	3	7	2.577	True

Structure

InChI

InChI=1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19)

InChIKey

FNYLWPVRPXGIIP-UHFFFAOYSA-N

Links

Gene (22 / 57)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(hydroxylation)			CYP1A2		D014223
CTD	increases(activity)			HIF1A		D014223
PubChem	AhR Potency (uM)	uM	11.515	AHR	-	GI(Protien) :
PubChem	AhR Potency (uM)	uM	29.814	AHR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	21.314	AR	-	GI(Protien) :
PubChem	Potency	uM	44.668	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	48.972	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	49.512	AR	-	GI(Protien) :
PubChem	IC50	uM		CBFB	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	35.481	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	68.590	ESR1	-	GI(Protien) :
PubChem	Potency	uM	39.811	GAA	-	GI(Protien) :
PubChem	Potency	uM	10.000	HIF1A	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	24.544	HSPB1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	29.847	HSPB1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	49.512	HSPB1	-	GI(Protien) :
PubChem	Potency	uM	2.311	IDH1	-	GI(Protien) :
PubChem	IC50	uM	4.613	JAK2	-	GI(Protien) :
PubChem	None	uM		JAK2	-	GI(Protien) :
PubChem	None	uM		JAK2	-	GI(Protien) :
PubChem	None	uM		KLK7	-	GI(Protien) :
PubChem	None	uM		KLK7	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	23.708	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	30.638	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	30.981	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	33.492	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	54.483	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	21.130	NR1H4	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	49.512	NR1H4	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	48.972	NR3C1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	23.708	PPARD	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	24.544	PPARD	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	23.915	PPARG	-	GI(Protien) :
PubChem	IC50	uM		RUNX1	-	GI(Protien) :
PubChem	Potency	uM	2.060	TDP1	-	GI(Protien) :
PubChem	Potency	uM	6.684	TDP1	-	GI(Protien) :
PubChem	Potency	uM	8.200	TDP1	-	GI(Protien) :
PubChem	Potency	uM	14.963	TDP1	-	GI(Protien) :
PubChem	Potency	uM	15.849	TDP1	-	GI(Protien) :
PubChem	Potency	uM	17.783	TDP1	-	GI(Protien) :
PubChem	Potency	uM	18.356	TDP1	-	GI(Protien) :
PubChem	Potency	uM	22.387	THRB	-	GI(Protien) :
PubChem	None	uM		TNFRSF10B	-	GI(Protien) :
PubChem	None	uM		TNFRSF10B	-	GI(Protien) :
PubChem	None	uM		TNFRSF10B	-	GI(Protien) :
PubChem	Potency	uM	12.589	TP53	-	GI(Protien) :
ChEMBL	AC50	nM	5011.870	CYP1A2	-	Target : CHEMBL3356
ChEMBL	Potency	nM	39810.700	GAA	-	Target : CHEMBL2608
ChEMBL	Potency	nM	10000.000	HIF1A	-	Target : CHEMBL4261
ChEMBL	Potency	nM	3162.300	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	5011.900	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	1258.900	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	7943.300	HSD17B10	-	Target : CHEMBL4159
ChEMBL	IC50	nM	4613.000	JAK2	-	Target : CHEMBL2971
ChEMBL	Potency	nM	12589.300	TP53	-	Target : CHEMBL4096

Download gene sets

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