Tan Lab | DSigDB

Gene Set: D4 : CTD - Thiram

Collection

D4 : CTD

Chemical Name

Thiram ( From PubChem : THIRAM )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Approved	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
240.433 g/mol	0	6	2.0608	True

Structure

InChI

InChI=1S/C6H12N2S4/c1-7(2)5(9)11-12-6(10)8(3)4/h1-4H3

InChIKey

KUAZQDVKQLNFPE-UHFFFAOYSA-N

Links

Gene (76 / 136)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(activity)			AKR1C2		D013893
CTD	increases(expression)			AMPD3		D013893
CTD	increases(expression)			ATF3		D013893
CTD	decreases(expression)			CCR2		D013893
CTD	increases(expression)			CD86		D013893
CTD	increases(expression)			CREB1		D013893
CTD	increases(expression)			CREM		D013893
CTD	affects(reaction)			CXCL8		D013893
CTD	increases(secretion)			CXCL8		D013893
CTD	increases(expression)			CXCL8		D013893
CTD	increases(secretion)			CXCL8		D013893
CTD	increases(expression)			DNAJB4		D013893
CTD	increases(expression)			FTH1		D013893
CTD	increases(expression)			FTL		D013893
CTD	increases(expression)			GCLM		D013893
CTD	increases(expression)			HMOX1		D013893
CTD	decreases(activity)			HSD11B2		D013893
CTD	decreases(reaction)			HSD11B2		D013893
CTD	decreases(activity)			HSD11B2		D013893
CTD	increases(reaction)			HSD11B2		D013893
CTD	decreases(reaction)			HSD11B2		D013893
CTD	increases(oxidation)			HSD11B2		D013893
CTD	decreases(activity)			HSD11B2		D013893
CTD	increases(expression)			HSPA6		D013893
CTD	increases(expression)			MYC		D013893
CTD	increases(expression)			NAMPT		D013893
CTD	decreases(expression)			NFKB1		D013893
CTD	increases(expression)			NQO1		D013893
CTD	affects(binding)			NR3C1		D013893
CTD	decreases(reaction)			NR3C1		D013893
CTD	decreases(activity)			PRKCA		D013893
CTD	decreases(activity)			PRKCB		D013893
CTD	increases(activity)			PRKCD		D013893
CTD	decreases(activity)			PRKCE		D013893
CTD	decreases(activity)			PRKCG		D013893
CTD	increases(expression)			PTGS2		D013893
CTD	increases(expression)			SEL1L3		D013893
CTD	decreases(expression)			SFTPA1		D013893
CTD	decreases(reaction)			SFTPA1		D013893
CTD	decreases(reaction)			SFTPB		D013893
CTD	increases(expression)			SFTPB		D013893
CTD	increases(expression)			SLC7A11		D013893
CTD	increases(expression)			SQSTM1		D013893
CTD	decreases(expression)			SYNE2		D013893
CTD	increases(expression)			TNF		D013893
CTD	decreases(expression)			TNNT2		D013893
CTD	increases(expression)			TRIM16L		D013893
CTD	increases(expression)			TXNRD1		D013893
PubChem	Potency	uM	0.079	ALDH1A1	-	GI(Protien) :
PubChem	Potency	uM	0.126	ALDH1A1	-	GI(Protien) :
PubChem	Potency	uM	0.501	ALDH1A1	-	GI(Protien) :
PubChem	None	uM		APP	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.061	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.170	AR	-	GI(Protien) :
PubChem	Potency	uM	2.512	ATXN2	-	GI(Protien) :
PubChem	IC50	uM		CACNA1B	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.015	CYP19A1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.048	CYP19A1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.188	CYP19A1	-	GI(Protien) :
PubChem	Potency	uM	15.849	CYP3A4	-	GI(Protien) :
PubChem	None	uM		DRD3	-	GI(Protien) :
PubChem	Potency	uM	1.122	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	1.259	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	39.811	GAPDH	-	GI(Protien) :
PubChem	None	uM		GAPDH	-	GI(Protien) :
PubChem	Potency	uM	1.334	GMNN	-	GI(Protien) :
PubChem	Potency	uM	21.136	GMNN	-	GI(Protien) :
PubChem	None	uM		GNAI1	-	GI(Protien) :
PubChem	Potency	uM	0.708	HPGD	-	GI(Protien) :
PubChem	Potency	uM	1.000	HPGD	-	GI(Protien) :
PubChem	AC50_uM	uM	7.741	HSP90AA1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.138	HSPB1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.188	HSPB1	-	GI(Protien) :
PubChem	Potency	uM	1.000	HTT	-	GI(Protien) :
PubChem	None	uM		INS	-	GI(Protien) :
PubChem	IC50	uM	0.223	JAK2	-	GI(Protien) :
PubChem	irf1 Inhibition [Ba/F3 cells] (IC50)	uM	2.375	JAK2	-	GI(Protien) :
PubChem	irf1 Inhibition [HEL cells] (IC50)	uM	13.470	JAK2	-	GI(Protien) :
PubChem	None	uM		JAK2	-	GI(Protien) :
PubChem	None	uM		JAK2	-	GI(Protien) :
PubChem	None	uM		JAK2	-	GI(Protien) :
PubChem	Potency	uM	14.125	KAT2A	-	GI(Protien) :
PubChem	Potency	uM	31.623	KAT2A	-	GI(Protien) :
PubChem	Potency	uM	44.668	KCNH2		GI(Protien) :
PubChem	Potency	uM	44.668	KCNH2		GI(Protien) :
PubChem	None	uM		KCNQ1	-	GI(Protien) :
PubChem	None	uM		MAP1LC3A	-	GI(Protien) :
PubChem	Mean Mutant EC50	uM	0.080	MDM2	-	GI(Protien) :
PubChem	EC50	uM	0.180	MDM2	-	GI(Protien) :
PubChem	Mean Wild-type EC50	uM	0.400	MDM2	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	42.163	NFE2L2	-	GI(Protien) :
PubChem	None	uM		NFKBIA	-	GI(Protien) :
PubChem	None	uM		NLRP1	-	GI(Protien) :
PubChem	None	uM		NR2E3	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.061	NR3C1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM		NR3C1	-	GI(Protien) :
PubChem	Potency	uM	14.125	PKM	-	GI(Protien) :
PubChem	Potency	uM	0.336	PLK1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.206	PPARD	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	1.100	PPARD	-	GI(Protien) :
PubChem	None	uM		PRMT1	-	GI(Protien) :
PubChem	None	uM		PRMT1	-	GI(Protien) :
PubChem	None	uM		PTGER2	-	GI(Protien) :
PubChem	None	uM		RGS12	-	GI(Protien) :
PubChem	Potency	uM	44.668	RXRA	-	GI(Protien) :
PubChem	None	uM		SELE	-	GI(Protien) :
PubChem	None	uM		SMARCA2	-	GI(Protien) :
PubChem	Potency	uM	0.009	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.130	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.133	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.133	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.146	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.146	TDP1	-	GI(Protien) :
PubChem	Potency	uM	2.512	VDR	-	GI(Protien) :
PubChem	Potency	uM	11.220	VDR	-	GI(Protien) :
ChEMBL	Potency	nM	79.400	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	125.900	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	501.200	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	15848.900	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	1258.900	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	1122.000	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	39810.700	GAPDH	-	Target : CHEMBL2284
ChEMBL	Potency	nM	707.900	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	1000.000	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	12589.300	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	50.100	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	1000.000	HTT	-	Target : CHEMBL5514
ChEMBL	Activity	um	2.380	JAK2	-	Target : CHEMBL2971
ChEMBL	Activity	um	13.470	JAK2	-	Target : CHEMBL2971
ChEMBL	IC50	nM	223.000	JAK2	-	Target : CHEMBL2971
ChEMBL	Potency	nM	14125.400	KAT2A	-	Target : CHEMBL5501
ChEMBL	Potency	nM	31622.800	KAT2A	-	Target : CHEMBL5501
ChEMBL	Potency	nM	25118.900	KDM4E	-	Target : CHEMBL1293226
ChEMBL	EC50	nM	180.000	MDM2	-	Target : CHEMBL5023
ChEMBL	Potency	nM	14125.400	PKM	-	Target : CHEMBL1075189

Download gene sets

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