Tan Lab | DSigDB

Gene Set: D4 : CTD - Thioridazine

Collection

D4 : CTD

Chemical Name

Thioridazine ( From PubChem : THIORIDAZINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
370.575 g/mol	0	3	5.8885	False(3/4)

Structure

InChI

InChI=1S/C21H26N2S2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3/t16-/m0/s1

InChIKey

KLBQZWRITKRQQV-INIZCTEOSA-N

Links

Gene (49 / 74)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(expression)			AP1S1		D013881
CTD	increases(expression)			ASAH1		D013881
CTD	increases(expression)			ASNS		D013881
CTD	increases(expression)			C10ORF10		D013881
CTD	increases(activity)			CASP3		D013881
CTD	decreases(expression)			CCND1		D013881
CTD	increases(phosphorylation)			CDC25A		D013881
CTD	decreases(expression)			CDK4		D013881
CTD	increases(expression)			CDKN1A		D013881
CTD	increases(expression)			CDKN2A		D013881
CTD	decreases(reaction)			CES1		D013881
CTD	increases(hydrolysis)			CES1		D013881
CTD	decreases(expression)			CRH		D013881
CTD	affects(cotreatment)			CYP1A2		D013881
CTD	affects(response to substance)			CYP1A2		D013881
CTD	increases(activity)			CYP1A2		D013881
CTD	increases(metabolic processing)			CYP1A2		D013881
CTD	decreases(activity)			CYP2A6		D013881
CTD	affects(cotreatment)			CYP2C19		D013881
CTD	affects(response to substance)			CYP2C19		D013881
CTD	decreases(activity)			CYP2C19		D013881
CTD	affects(cotreatment)			CYP2C9		D013881
CTD	affects(response to substance)			CYP2C9		D013881
CTD	decreases(activity)			CYP2C9		D013881
CTD	affects(cotreatment)			CYP2D6		D013881
CTD	affects(response to substance)			CYP2D6		D013881
CTD	increases(activity)			CYP2D6		D013881
CTD	increases(metabolic processing)			CYP2D6		D013881
CTD	decreases(activity)			CYP2E1		D013881
CTD	affects(cotreatment)			CYP3A4		D013881
CTD	affects(response to substance)			CYP3A4		D013881
CTD	decreases(activity)			CYP3A4		D013881
CTD	decreases(phosphorylation)			EIF4EBP1		D013881
CTD	increases(expression)			FABP1		D013881
CTD	increases(expression)			FNDC4		D013881
CTD	increases(expression)			GDPD3		D013881
CTD	increases(expression)			HPN		D013881
CTD	increases(expression)			INHBE		D013881
CTD	decreases(reaction)			KCNH2		D013881
CTD	increases(transport)			KCNH2		D013881
CTD	decreases(activity)			KCNH2		D013881
CTD	increases(expression)			LSS		D013881
CTD	increases(expression)			NR0B2		D013881
CTD	increases(expression)			NUPR1		D013881
CTD	increases(expression)			PHYH		D013881
CTD	increases(expression)			PRL		D013881
CTD	increases(expression)			SERPINA3		D013881
CTD	decreases(reaction)			SLC22A2		D013881
CTD	increases(uptake)			SLC22A2		D013881
CTD	decreases(expression)			SLC2A3		D013881
CTD	decreases(expression)			TAGLN		D013881
CTD	increases(expression)			WIPI1		D013881
PubChem	Potency	uM	25.119	ATXN2	-	GI(Protien) :
PubChem	Potency	uM	28.184	CBX1	-	GI(Protien) :
PubChem	Potency	uM	2.818	DRD1	-	GI(Protien) :
PubChem	Potency	uM	17.783	EHMT2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	23.915	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	23.915	ESR1	-	GI(Protien) :
PubChem	None	uM		HTR1A		GI(Protien) :
PubChem	None	uM		HTR2A		GI(Protien) :
PubChem	None	uM		HTR2A		GI(Protien) :
PubChem	None	uM		HTR2C		GI(Protien) :
PubChem	None	uM		HTR2C		GI(Protien) :
PubChem	None	uM		HTR6		GI(Protien) :
PubChem	None	uM		HTR7		GI(Protien) :
PubChem	Potency-Replicate_1	uM	26.601	PPARD	-	GI(Protien) :
PubChem	None	uM		PPARG	-	GI(Protien) :
PubChem	Potency	uM	7.080	TDP1	-	GI(Protien) :
PubChem	Potency	uM	7.499	TDP1	-	GI(Protien) :
PubChem	Potency	uM	7.499	TDP1	-	GI(Protien) :
PubChem	Potency	uM	15.849	TDP1	-	GI(Protien) :
ChEMBL	Potency	nM	28183.800	CBX1	-	Target : CHEMBL1741193
ChEMBL	Potency	nM	2818.400	DRD1	-	Target : CHEMBL2056
ChEMBL	Potency	nM	17782.800	EHMT2	-	Target : CHEMBL6032

Download gene sets

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