Tan Lab | DSigDB

Gene Set: D4 : CTD - Thioguanine

Collection

D4 : CTD

Chemical Name

Thioguanine ( From PubChem : 6-THIOGUANINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
167.192 g/mol	3	4	1.1789	True

Structure

InChI

InChI=1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)

InChIKey

WYWHKKSPHMUBEB-UHFFFAOYSA-N

Links

Gene (23 / 53)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(reaction)			ABCC4		D013866
CTD	decreases(response to substance)			ABCC4		D013866
CTD	decreases(reaction)			ABCC5		D013866
CTD	decreases(response to substance)			ABCC5		D013866
CTD	decreases(response to substance)			BIRC2		D013866
CTD	increases(splicing)			DMD		D013866
CTD	increases(expression)			IMPDH2		D013866
CTD	increases(response to substance)			MSH2		D013866
CTD	decreases(activity)			OCLN		D013866
PubChem	AhR Potency (uM)	uM	28.180	AHR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	61.131	AHR	-	GI(Protien) :
PubChem	AhR Potency (uM)	uM	61.131	AHR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	6.917	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	10.682	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	16.930	AR	-	GI(Protien) :
PubChem	None	uM		CYP19A1	-	GI(Protien) :
PubChem	Potency	uM	2.239	EHMT2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.750	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	8.416	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	17.575	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	18.977	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	21.132	ESR1	-	GI(Protien) :
PubChem	Potency	uM	1.122	HBB	-	GI(Protien) :
PubChem	Potency	uM	5.012	HBB	-	GI(Protien) :
PubChem	Potency	uM	31.623	HBB	-	GI(Protien) :
PubChem	Potency	uM	35.481	HPGD	-	GI(Protien) :
PubChem	Potency	uM	2.311	IDH1	-	GI(Protien) :
PubChem	None	uM		ITGA4	-	GI(Protien) :
PubChem	None	uM		MITF	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	3.712	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	4.733	NFE2L2	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	5.515	NFE2L2	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	5.958	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	23.915	NR3C1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	30.111	NR3C1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	43.641	NR3C1	-	GI(Protien) :
PubChem	AC50_uM	uM	0.260	PAX8	-	GI(Protien) :
PubChem	AC50_uM	uM	0.260	PAX8	-	GI(Protien) :
PubChem	AC50_uM	uM	1.180	PAX8	-	GI(Protien) :
PubChem	None	uM		PAX8	-	GI(Protien) :
PubChem	Potency	uM	1.158	TDP1	-	GI(Protien) :
PubChem	Potency	uM	1.836	TDP1	-	GI(Protien) :
PubChem	Potency	uM	1.884	TDP1	-	GI(Protien) :
PubChem	Potency	uM	2.114	TDP1	-	GI(Protien) :
PubChem	Potency	uM	2.593	TDP1	-	GI(Protien) :
PubChem	Potency	uM	2.661	TDP1	-	GI(Protien) :
PubChem	None	uM		TNFRSF10B	-	GI(Protien) :
ChEMBL	Potency	nM	2238.700	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	1122.020	HBB	-	Target : CHEMBL4331
ChEMBL	Potency	nM	31622.800	HBB	-	Target : CHEMBL4331
ChEMBL	Potency	nM	5011.900	HBB	-	Target : CHEMBL4331
ChEMBL	Potency	nM	35481.300	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	5623.400	KDM4A	-	Target : CHEMBL5896

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