Tan Lab | DSigDB

Gene Set: D4 : CTD - Tetracycline

Collection

D4 : CTD

Chemical Name

Tetracycline ( From PubChem : TETRACYCLINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
444.435 g/mol	6	10	0.3293	False(3/4)

Structure

InChI

InChI=1S/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25-26,29,31-32H,7H2,1-3H3,(H2,23,30)/t9-,10-,15-,21+,22-/m0/s1

InChIKey

NWXMGUDVXFXRIG-WESIUVDSSA-N

Links

Gene (46 / 74)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(transport)			ABCC4		D013752
CTD	decreases(expression)			AP1S1		D013752
CTD	increases(expression)			ASNS		D013752
CTD	increases(expression)			C10ORF10		D013752
CTD	increases(activity)			CYP3A4		D013752
CTD	increases(expression)			CYP3A4		D013752
CTD	increases(expression)			FNDC4		D013752
CTD	decreases(activity)			GSTM3		D013752
CTD	affects(metabolic processing)			GSTP1		D013752
CTD	decreases(activity)			GSTP1		D013752
CTD	decreases(reaction)			GSTP1		D013752
CTD	decreases(reaction)			IL1B		D013752
CTD	increases(expression)			IL1B		D013752
CTD	increases(expression)			INHBE		D013752
CTD	decreases(reaction)			MMP13		D013752
CTD	increases(expression)			MMP13		D013752
CTD	decreases(activity)			MMP13		D013752
CTD	decreases(activity)			MMP2		D013752
CTD	decreases(reaction)			MMP3		D013752
CTD	increases(expression)			MMP3		D013752
CTD	decreases(activity)			MMP3		D013752
CTD	decreases(activity)			MMP8		D013752
CTD	increases(expression)			NUPR1		D013752
CTD	affects(binding)			PRNP		D013752
CTD	decreases(reaction)			PRNP		D013752
CTD	increases(expression)			SERPINA3		D013752
CTD	increases(export)			SLC22A6		D013752
CTD	increases(uptake)			SLC22A6		D013752
CTD	decreases(reaction)			SLC22A6		D013752
CTD	decreases(reaction)			SLC22A7		D013752
CTD	increases(transport)			SLC22A7		D013752
CTD	increases(uptake)			SLC22A7		D013752
CTD	decreases(reaction)			SLC22A7		D013752
CTD	increases(uptake)			SLC22A8		D013752
CTD	increases(export)			SLC22A9		D013752
CTD	increases(uptake)			SLC22A9		D013752
CTD	decreases(reaction)			SLC22A9		D013752
CTD	decreases(expression)			TAGLN		D013752
CTD	decreases(expression)			TOP2A		D013752
CTD	increases(expression)			WIPI1		D013752
PubChem	None	uM		ADRBK1	-	GI(Protien) :
PubChem	None	uM		BCL2L1	-	GI(Protien) :
PubChem	None	uM		ESR1	-	GI(Protien) :
PubChem	None	uM		ESR2	-	GI(Protien) :
PubChem	None	uM		GSTO1	-	GI(Protien) :
PubChem	IC50	uM	22.447	HSP90AA1	-	GI(Protien) :
PubChem	None	uM		HSP90AA1	-	GI(Protien) :
PubChem	None	uM		MCL1	-	GI(Protien) :
PubChem	None	uM		PLA2G7	-	GI(Protien) :
PubChem	None	uM		PPP1CA	-	GI(Protien) :
PubChem	IC50	uM	8.330	PTPN7	-	GI(Protien) :
PubChem	Potency	uM	22.387	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	12.589	BAZ2B	-	GI(Protien) :
PubChem	None	uM		BCL2L1	-	GI(Protien) :
PubChem	IC50	uM		EIF4H	-	GI(Protien) :
PubChem	None	uM		GSTO1	-	GI(Protien) :
PubChem	None	uM		MCL1	-	GI(Protien) :
PubChem	IC50	uM		PABPC1	-	GI(Protien) :
PubChem	None	uM		PLA2G7	-	GI(Protien) :
PubChem	Potency	uM	3.162	POLB	-	GI(Protien) :
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2C19	-	Target : CHEMBL3622
ChEMBL	Inhibition	-		CYP2C9	-	Target : CHEMBL3397
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Activity	-		F2RL1	-	Target : CHEMBL5963
ChEMBL	Activity	-		F2RL1	-	Target : CHEMBL5963
ChEMBL	Activity	-		F2RL1	-	Target : CHEMBL5963
ChEMBL	IC50	nM	22447.400	HSP90AA1	-	Target : CHEMBL2095165
ChEMBL	IC50	nM	22447.400	HSP90AB1	-	Target : CHEMBL2095165
ChEMBL	IC50	nM	8330.000	PTPN7	-	Target : CHEMBL2219
ChEMBL	Activity	-		SOD1	-	Target : CHEMBL2354
ChEMBL	Activity	-		SOD1	-	Target : CHEMBL2354

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