Tan Lab | DSigDB

Gene Set: D4 : CTD - Teniposide

Collection

D4 : CTD

Chemical Name

Teniposide ( From PubChem : TENIPOSIDE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
656.654 g/mol	3	14	2.7529	False(2/4)

Structure

InChI

InChI=1S/C32H32O13S/c1-37-19-6-13(7-20(38-2)25(19)33)23-14-8-17-18(42-12-41-17)9-15(14)28(16-10-39-30(36)24(16)23)44-32-27(35)26(34)29-21(43-32)11-40-31(45-29)22-4-3-5-46-22/h3-9,16,21,23-24,26-29,31-35H,10-12H2,1-2H3

InChIKey

NRUKOCRGYNPUPR-UHFFFAOYSA-N

Links

Gene (24 / 41)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(methylation)			CYP3A4		D013713
CTD	decreases(reaction)			CYP3A4		D013713
CTD	decreases(methylation)			CYP3A5		D013713
CTD	decreases(response to substance)			FGF2		D013713
CTD	decreases(reaction)			GSTP1		D013713
CTD	increases(metabolic processing)			GSTP1		D013713
CTD	decreases(expression)			MYC		D013713
CTD	decreases(expression)			ODC1		D013713
CTD	affects(cotreatment)			TOP2A		D013713
CTD	decreases(response to substance)			TOP2A		D013713
PubChem	Potency	uM	11.156	APOBEC3F	-	GI(Protien) :
PubChem	Potency	uM	35.481	ATM	-	GI(Protien) :
PubChem	None	uM		JAK2	-	GI(Protien) :
PubChem	None	uM		KCNQ1	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	None	uM		MITF	-	GI(Protien) :
PubChem	IC50	uM	0.049	NCOA1	-	GI(Protien) :
PubChem	IC50	uM	0.443	NCOA1	-	GI(Protien) :
PubChem	None	uM		NCOA1	-	GI(Protien) :
PubChem	IC50	uM	0.091	NCOA3	-	GI(Protien) :
PubChem	IC50	uM	0.093	NCOA3	-	GI(Protien) :
PubChem	IC50	uM	0.400	NCOA3	-	GI(Protien) :
PubChem	None	uM		NCOA3	-	GI(Protien) :
PubChem	None	uM		NCOA3	-	GI(Protien) :
PubChem	None	uM		NCOA3	-	GI(Protien) :
PubChem	None	uM		NR5A1	-	GI(Protien) :
PubChem	None	uM		NR5A2	-	GI(Protien) :
PubChem	None	uM		PAX8	-	GI(Protien) :
PubChem	Potency	uM	0.023	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.026	TDP1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.268	AR	-	GI(Protien) :
PubChem	AR Potency (uM)	uM	2.764	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	1.693	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	6.740	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	3.189	NR3C1	-	GI(Protien) :
PubChem	Potency	uM	0.012	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.013	TDP1	-	GI(Protien) :
PubChem	None	uM		STK33	-	GI(Protien) :

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