Tan Lab | DSigDB

Gene Set: D4 : CTD - Tacrine

Collection

D4 : CTD

Chemical Name

Tacrine ( From PubChem : TACRINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Approved	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
198.264 g/mol	1	2	3.277	True

Structure

InChI

InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15)

InChIKey

Links

Gene (17 / 38)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(activity)			ACHE		D013619
CTD	decreases(activity)			BCHE		D013619
CTD	decreases(activity)			CES1		D013619
CTD	affects(binding)			CES1		D013619
CTD	decreases(activity)			CES2		D013619
CTD	affects(binding)			CHRM1		D013619
CTD	affects(reaction)			CHRM1		D013619
CTD	affects(activity)			CHRNA4		D013619
CTD	affects(binding)			CHRNA4		D013619
CTD	increases(reaction)			CHRNA4		D013619
CTD	affects(activity)			CHRNB2		D013619
CTD	affects(binding)			CHRNB2		D013619
CTD	increases(reaction)			CHRNB2		D013619
CTD	decreases(reaction)			CYP1A1		D013619
CTD	increases(activity)			CYP1A1		D013619
CTD	decreases(reaction)			CYP1A2		D013619
CTD	increases(activity)			CYP1A2		D013619
CTD	increases(response to substance)			CYP3A4		D013619
CTD	decreases(activity)			KCNH2		D013619
CTD	decreases(reaction)			SLC22A2		D013619
CTD	increases(uptake)			SLC22A2		D013619
CTD	decreases(reaction)			SLC47A1		D013619
CTD	increases(uptake)			SLC47A1		D013619
PubChem	AhR Potency (uM)	uM	16.580	AHR	-	GI(Protien) :
PubChem	AhR Potency (uM)	uM	16.785	AHR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	61.131	AHR	-	GI(Protien) :
PubChem	Potency	uM	12.589	ALOX15	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	13.336	TDP1	-	GI(Protien) :
PubChem	Potency	uM	16.789	TDP1	-	GI(Protien) :
ChEMBL	Potency	nM	12589.300	ALOX15	-	Target : CHEMBL2903
ChEMBL	AC50	nM	3162.280	CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	AC50	nM	501.190	CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340

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