Tan Lab | DSigDB

Gene Set: D4 : CTD - 2'-hydroxychalcone

Collection

D4 : CTD

Chemical Name

2'-hydroxychalcone ( From PubChem : 2'-HYDROXYCHALCONE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
224.255 g/mol	1	2	3.2883	True

Structure

InChI

InChI=1S/C15H12O2/c16-14-9-5-4-8-13(14)15(17)11-10-12-6-2-1-3-7-12/h1-11,16H/b11-10+

InChIKey

Links

Gene (12 / 20)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(reaction)			CYP1A1		C013031
CTD	increases(expression)			CYP1A1		C013031
CTD	decreases(activity)			CYP1A1		C013031
CTD	decreases(reaction)			CYP1B1		C013031
CTD	increases(expression)			CYP1B1		C013031
CTD	decreases(activity)			CYP1B1		C013031
PubChem	None	uM		ABHD5	-	GI(Protien) :
PubChem	Potency	uM	44.668	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	20.596	GMNN	-	GI(Protien) :
PubChem	None	uM		IL1B	-	GI(Protien) :
PubChem	Potency	uM	3.663	NFE2L2	-	GI(Protien) :
PubChem	None	uM		PLIN5	-	GI(Protien) :
PubChem	Potency	uM	10.322	TDP1	-	GI(Protien) :
PubChem	Potency	uM	14.125	VDR	-	GI(Protien) :
PubChem	Potency	uM	17.783	VDR	-	GI(Protien) :
PubChem	Potency	uM	23.778	VDR	-	GI(Protien) :
ChEMBL	Inhibition	-		ABCB1	-	Target : CHEMBL4302
ChEMBL	Activity	-		CRYZ	-	Target : CHEMBL6118
ChEMBL	Potency	nM	44668.400	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	3662.600	NFE2L2	-	Target : CHEMBL1075094

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