Tan Lab | DSigDB

Gene Set: D4 : CTD - Sotalol

Collection

D4 : CTD

Chemical Name

Sotalol ( From PubChem : SOTALOL )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Approved	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
272.364 g/mol	3	5	2.6342	True

Structure

InChI

InChI=1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3/t12-/m0/s1

InChIKey

Links

Gene (23 / 39)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(transport)			ABCB1		D013015
CTD	decreases(reaction)			ABCB1		D013015
CTD	affects(binding)			ADRB1		D013015
CTD	decreases(reaction)			ADRB1		D013015
CTD	increases(abundance)			ADRB1		D013015
CTD	affects(binding)			ADRB2		D013015
CTD	affects(binding)			ADRB2		D013015
CTD	decreases(abundance)			ADRB2		D013015
CTD	increases(expression)			ASAH1		D013015
CTD	decreases(expression)			ASNS		D013015
CTD	increases(expression)			ASNS		D013015
CTD	increases(expression)			C10ORF10		D013015
CTD	increases(expression)			FNDC4		D013015
CTD	decreases(expression)			GDPD3		D013015
CTD	increases(expression)			GDPD3		D013015
CTD	decreases(expression)			INHBE		D013015
CTD	increases(expression)			INHBE		D013015
CTD	decreases(response to substance)			KCNH2		D013015
CTD	decreases(activity)			KCNH2		D013015
CTD	decreases(reaction)			KCNH2		D013015
CTD	affects(binding)			KCNH2		D013015
CTD	decreases(activity)			KCNH2		D013015
CTD	decreases(expression)			LSS		D013015
CTD	decreases(expression)			NR0B2		D013015
CTD	increases(expression)			NR0B2		D013015
CTD	increases(expression)			NUPR1		D013015
CTD	increases(expression)			PHYH		D013015
CTD	increases(expression)			SERPINA3		D013015
CTD	increases(expression)			SLC2A3		D013015
CTD	increases(expression)			WIPI1		D013015
PubChem	Potency-Replicate_1	uM	33.492	AR	-	GI(Protien) :
ChEMBL	Selectivity	-		ADRB1	-	Target : CHEMBL213
ChEMBL	Selectivity	-		ADRB2	-	Target : CHEMBL210
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2C19	-	Target : CHEMBL3622
ChEMBL	Inhibition	-		CYP2C9	-	Target : CHEMBL3397
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340

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