Tan Lab | DSigDB

Gene Set: D4 : CTD - betulinic acid

Collection

D4 : CTD

Chemical Name

betulinic acid ( From PubChem : NSC113090 )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
456.7 g/mol	2	3	7.0895	False(3/4)

Structure

InChI

InChI=1S/C30H48O3/c1-18(2)19-10-15-30(25(32)33)17-16-28(6)20(24(19)30)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h19-24,31H,1,8-17H2,2-7H3,(H,32,33)

InChIKey

QGJZLNKBHJESQX-UHFFFAOYSA-N

Links

Gene (25 / 59)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(reaction)			AKT1		C002070
CTD	increases(phosphorylation)			AKT1		C002070
CTD	affects(cotreatment)			BAX		C002070
CTD	increases(activity)			BAX		C002070
CTD	decreases(reaction)			BAX		C002070
CTD	decreases(reaction)			BIRC5		C002070
CTD	increases(expression)			BIRC5		C002070
CTD	decreases(response to substance)			BIRC5		C002070
CTD	increases(cleavage)			CASP3		C002070
CTD	increases(reaction)			CASP3		C002070
CTD	increases(activity)			CASP3		C002070
CTD	decreases(reaction)			CASP3		C002070
CTD	increases(activity)			CASP7		C002070
CTD	decreases(reaction)			EGFR		C002070
CTD	increases(phosphorylation)			EGFR		C002070
CTD	decreases(reaction)			MAPK1		C002070
CTD	increases(phosphorylation)			MAPK1		C002070
CTD	decreases(reaction)			MAPK3		C002070
CTD	increases(phosphorylation)			MAPK3		C002070
CTD	decreases(reaction)			PTHLH		C002070
CTD	increases(expression)			PTHLH		C002070
CTD	decreases(expression)			PTHLH		C002070
CTD	decreases(secretion)			PTHLH		C002070
CTD	decreases(response to substance)			PTHLH		C002070
CTD	decreases(reaction)			TNFSF11		C002070
CTD	increases(expression)			TNFSF11		C002070
CTD	decreases(activity)			TOP1		C002070
CTD	decreases(activity)			TOP2A		C002070
PubChem	None	uM		CFTR	-	GI(Protien) :
PubChem	None	uM		CFTR	-	GI(Protien) :
PubChem	None	uM		DNMT1	-	GI(Protien) :
PubChem	None	uM		DRD2	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	IC50	uM	9.240	SAE1	-	GI(Protien) :
PubChem	IC50	uM	13.160	SAE1	-	GI(Protien) :
PubChem	None	uM		STK33	-	GI(Protien) :
PubChem	Potency	uM	3.663	TDP1	-	GI(Protien) :
PubChem	Potency	uM	5.805	TDP1	-	GI(Protien) :
PubChem	IC50	uM	9.240	UBA2	-	GI(Protien) :
PubChem	IC50	uM	13.160	UBA2	-	GI(Protien) :
PubChem	IC50	uM	9.240	UBE2I	-	GI(Protien) :
PubChem	IC50	uM	13.160	UBE2I	-	GI(Protien) :
PubChem	None	uM		CFTR	-	GI(Protien) :
PubChem	None	uM		DNMT1	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	None	uM		PLCG1	-	GI(Protien) :
PubChem	Potency	uM	6.513	TDP1	-	GI(Protien) :
PubChem	Potency	uM	7.308	TDP1	-	GI(Protien) :
ChEMBL	Activity	-		GLI1	-	Target : CHEMBL5461
ChEMBL	Activity	-		GLI1	-	Target : CHEMBL5461
ChEMBL	Activity	-		GLI1	-	Target : CHEMBL5461
ChEMBL	Activity	-		GLI1	-	Target : CHEMBL5461
ChEMBL	Activity	-		GSK3B	-	Target : CHEMBL262
ChEMBL	IC50	nM	13160.000	SAE1	-	Target : CHEMBL2095174
ChEMBL	IC50	nM	9240.000	SAE1	-	Target : CHEMBL2095174
ChEMBL	IC50	nM	13160.000	UBA2	-	Target : CHEMBL2095174
ChEMBL	IC50	nM	9240.000	UBA2	-	Target : CHEMBL2095174

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