Tan Lab | DSigDB

Gene Set: D4 : CTD - Prednisone

Collection

D4 : CTD

Chemical Name

Prednisone ( From PubChem : PREDNISONE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
358.428 g/mol	2	5	1.7658	True

Structure

InChI

InChI=1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1

InChIKey

XOFYZVNMUHMLCC-ZPOLXVRWSA-N

Links

Gene (35 / 61)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(expression)			A2M		D011241
CTD	increases(secretion)			ABCB1		D011241
CTD	decreases(reaction)			ABCB1		D011241
CTD	affects(transport)			ABCC3		D011241
CTD	increases(reaction)			ABCC3		D011241
CTD	increases(activity)			ABCC3		D011241
CTD	affects(binding)			AR		D011241
CTD	increases(activity)			AR		D011241
CTD	decreases(expression)			CCL11		D011241
CTD	decreases(expression)			CCL13		D011241
CTD	increases(expression)			CDKN1A		D011241
CTD	increases(expression)			CDKN1B		D011241
CTD	increases(expression)			CDKN2A		D011241
CTD	increases(expression)			CDKN2B		D011241
CTD	affects(response to substance)			GSTM1		D011241
CTD	increases(activity)			HIF1A		D011241
CTD	affects(cotreatment)			IFNG		D011241
CTD	decreases(reaction)			IFNG		D011241
CTD	increases(secretion)			IFNG		D011241
CTD	affects(binding)			IL12A		D011241
CTD	increases(expression)			IL12A		D011241
CTD	affects(binding)			IL12B		D011241
CTD	increases(expression)			IL12B		D011241
CTD	decreases(expression)			IL13		D011241
CTD	decreases(expression)			IL4		D011241
CTD	decreases(expression)			IL5		D011241
CTD	increases(expression)			PLAT		D011241
CTD	decreases(expression)			POMC		D011241
CTD	decreases(expression)			PYGM		D011241
CTD	decreases(activity)			RB1		D011241
CTD	decreases(phosphorylation)			RB1		D011241
CTD	increases(expression)			SERPINC1		D011241
CTD	decreases(reaction)			SLC22A2		D011241
CTD	increases(uptake)			SLC22A2		D011241
CTD	decreases(expression)			TGFB1		D011241
CTD	increases(expression)			TNF		D011241
CTD	affects(response to substance)			TYMS		D011241
CTD	increases(expression)			VDR		D011241
CTD	affects(response to substance)			VDR		D011241
PubChem	Ratio Potency (uM)	uM	0.035	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.078	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.098	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.124	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.133	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.145	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.145	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.213	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	9.439	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	24.436	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	30.638	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	54.483	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	2.464	NR3C1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	7.761	NR3C1	-	GI(Protien) :
PubChem	Potency	uM	17.783	NR3C1	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2C9	-	Target : CHEMBL3397
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	15848.900	HSD17B10	-	Target : CHEMBL4159

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