Tan Lab | DSigDB

Gene Set: D4 : CTD - Prednisolone

Collection

D4 : CTD

Chemical Name

Prednisolone ( From PubChem : PREDNISOLONE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Approved	Approved	Approved	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
360.444 g/mol	3	5	1.5576	True

Structure

InChI

InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

InChIKey

OIGNJSKKLXVSLS-VWUMJDOOSA-N

Links

Gene (47 / 75)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(expression)			ALB		D011239
CTD	affects(binding)			AR		D011239
CTD	increases(activity)			AR		D011239
CTD	increases(expression)			ARNTL		D011239
CTD	increases(expression)			ARRDC3		D011239
CTD	decreases(expression)			CCL2		D011239
CTD	increases(expression)			CCL3		D011239
CTD	increases(expression)			CCL4		D011239
CTD	increases(expression)			CCNG2		D011239
CTD	affects(cotreatment)			CD34		D011239
CTD	decreases(expression)			CD34		D011239
CTD	increases(expression)			CD84		D011239
CTD	increases(expression)			CRIM1		D011239
CTD	decreases(expression)			CRY1		D011239
CTD	decreases(expression)			CXCR2		D011239
CTD	decreases(expression)			CYP2S1		D011239
CTD	increases(expression)			CYP3A4		D011239
CTD	decreases(expression)			DBP		D011239
CTD	increases(expression)			HMGCS1		D011239
CTD	increases(activity)			HPGD		D011239
CTD	increases(expression)			HPGD		D011239
CTD	increases(metabolic processing)			HSD11B2		D011239
CTD	decreases(response to substance)			IGF1		D011239
CTD	increases(expression)			IGF1		D011239
CTD	decreases(expression)			IL4		D011239
CTD	decreases(expression)			IL5		D011239
CTD	decreases(reaction)			IL6		D011239
CTD	increases(secretion)			IL6		D011239
CTD	increases(expression)			KLHL24		D011239
CTD	decreases(response to substance)			KMT2A		D011239
CTD	decreases(expression)			MUC16		D011239
CTD	decreases(expression)			NR1D1		D011239
CTD	affects(response to substance)			NR3C1		D011239
CTD	decreases(reaction)			NR3C1		D011239
CTD	increases(activity)			NR3C1		D011239
CTD	affects(binding)			NR3C1		D011239
CTD	increases(activity)			NR3C1		D011239
CTD	affects(binding)			NR3C1		D011239
CTD	increases(activity)			NR3C1		D011239
CTD	increases(activity)			NR3C2		D011239
CTD	increases(expression)			PDCD4		D011239
CTD	increases(expression)			PER1		D011239
CTD	decreases(expression)			PER2		D011239
CTD	decreases(reaction)			PLA1A		D011239
CTD	increases(expression)			PLA1A		D011239
CTD	decreases(reaction)			PLA2G4A		D011239
CTD	increases(expression)			PLA2G4A		D011239
CTD	increases(expression)			PLCL1		D011239
CTD	increases(expression)			SLC7A11		D011239
CTD	increases(expression)			SRXN1		D011239
CTD	increases(expression)			TF		D011239
CTD	decreases(expression)			TGFB1		D011239
CTD	increases(expression)			TNF		D011239
CTD	decreases(expression)			VEGFA		D011239
CTD	increases(expression)			VLDLR		D011239
CTD	increases(expression)			ZBED8		D011239
PubChem	Ratio Potency (uM)	uM	0.030	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.039	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.039	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.048	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.055	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.068	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.073	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.084	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.085	AR	-	GI(Protien) :
PubChem	None	uM		CFTR	-	GI(Protien) :
PubChem	None	uM		IL1B	-	GI(Protien) :
PubChem	None	uM		ITGA4	-	GI(Protien) :
PubChem	Potency	uM	0.058	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	0.073	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.022	NR3C1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.024	NR3C1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.032	NR3C1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.056	NR3C1	-	GI(Protien) :
ChEMBL	Potency	nM	58.000	NFE2L2	-	Target : CHEMBL1075094

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