Tan Lab | DSigDB

Gene Set: D4 : CTD - Physostigmine

Collection

D4 : CTD

Chemical Name

Physostigmine ( From PubChem : PHYSOSTIGMINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
275.346 g/mol	1	5	2.1677	True

Structure

InChI

InChI=1S/C15H21N3O2/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2/h5-6,9,13H,7-8H2,1-4H3,(H,16,19)/t13-,15+/m1/s1

InChIKey

Links

Gene (10 / 30)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(acetylation)			AADAC		D010830
CTD	decreases(reaction)			AADAC		D010830
CTD	affects(cotreatment)			ACHE		D010830
CTD	decreases(activity)			ACHE		D010830
CTD	decreases(activity)			ACHE		D010830
CTD	decreases(reaction)			ACHE		D010830
CTD	decreases(activity)			ACHE		D010830
CTD	decreases(carbamoylation)			ACHE		D010830
CTD	decreases(reaction)			ACHE		D010830
CTD	decreases(activity)			ACHE		D010830
CTD	decreases(activity)			CES2		D010830
CTD	affects(binding)			CHRNA4		D010830
CTD	decreases(activity)			CHRNA4		D010830
CTD	affects(binding)			CHRNA4		D010830
CTD	decreases(reaction)			CHRNA4		D010830
CTD	affects(activity)			CHRNA4		D010830
CTD	increases(reaction)			CHRNA4		D010830
CTD	affects(binding)			CHRNB2		D010830
CTD	decreases(activity)			CHRNB2		D010830
CTD	affects(binding)			CHRNB2		D010830
CTD	decreases(reaction)			CHRNB2		D010830
CTD	affects(activity)			CHRNB2		D010830
CTD	increases(reaction)			CHRNB2		D010830
PubChem	Potency	uM	14.125	ALDH1A1	-	GI(Protien) :
PubChem	Potency	uM	44.668	EHMT2	-	GI(Protien) :
PubChem	None	uM		ESR1	-	GI(Protien) :
PubChem	Potency	uM	10.000	GLS	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	30.638	NFE2L2	-	GI(Protien) :
ChEMBL	Potency	nM	14125.400	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	44668.400	EHMT2	-	Target : CHEMBL6032

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