Tan Lab | DSigDB

Gene Set: D4 : CTD - Phenoxybenzamine

Collection

D4 : CTD

Chemical Name

Phenoxybenzamine ( From PubChem : PHENOXYBENZAMINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Not	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
303.826 g/mol	0	2	4.1949	True

Structure

InChI

InChI=1S/C18H22ClNO/c1-16(15-21-18-10-6-3-7-11-18)20(13-12-19)14-17-8-4-2-5-9-17/h2-11,16H,12-15H2,1H3/t16-/m1/s1

InChIKey

Links

Gene (11 / 25)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(reaction)			GSTP1		D010643
CTD	increases(metabolic processing)			GSTP1		D010643
CTD	decreases(reaction)			SLC22A1		D010643
CTD	increases(uptake)			SLC22A1		D010643
CTD	decreases(activity)			SLC22A1		D010643
CTD	affects(transport)			SLC22A2		D010643
CTD	decreases(reaction)			SLC22A2		D010643
CTD	decreases(reaction)			SLC22A2		D010643
CTD	increases(uptake)			SLC22A2		D010643
CTD	decreases(reaction)			SLC22A2		D010643
CTD	increases(uptake)			SLC22A2		D010643
CTD	decreases(activity)			SLC22A2		D010643
CTD	decreases(reaction)			SLC22A3		D010643
CTD	increases(uptake)			SLC22A3		D010643
CTD	decreases(activity)			SLC22A3		D010643
PubChem	Potency	uM	28.184	ALDH1A1	-	GI(Protien) :
PubChem	Potency	uM	0.009	CBX1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM		HSPB1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	11.882	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	48.558	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	31.623	TDP1	-	GI(Protien) :
ChEMBL	Potency	nM	28183.800	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	9.500	CBX1	-	Target : CHEMBL1741193
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340

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