Tan Lab | DSigDB

Gene Set: D4 : CTD - Perphenazine

Collection

D4 : CTD

Chemical Name

Perphenazine ( From PubChem : PERPHENAZINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
403.969 g/mol	1	4	3.8835	True

Structure

InChI

InChI=1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2

InChIKey

RGCVKNLCSQQDEP-UHFFFAOYSA-N

Links

Gene (34 / 68)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(reaction)			CES1		D010546
CTD	increases(hydrolysis)			CES1		D010546
CTD	decreases(reaction)			CYP1A1		D010546
CTD	increases(activity)			CYP1A1		D010546
CTD	decreases(reaction)			KCNH2		D010546
CTD	increases(transport)			KCNH2		D010546
CTD	increases(expression)			PRL		D010546
CTD	decreases(reaction)			SLC22A2		D010546
CTD	increases(uptake)			SLC22A2		D010546
CTD	increases(expression)			TNNI3		D010546
PubChem	None	uM		ABCB1	-	GI(Protien) :
PubChem	None	uM		APAF1	-	GI(Protien) :
PubChem	Potency	uM	14.125	ATXN2	-	GI(Protien) :
PubChem	Potency	uM	31.623	CBX1	-	GI(Protien) :
PubChem	None	uM		CHRM1	-	GI(Protien) :
PubChem	None	uM		CHRM4	-	GI(Protien) :
PubChem	None	uM		CHRM5	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	0.032	CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	0.200	CYP2D6	-	GI(Protien) :
PubChem	None	uM		CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	0.794	DRD1	-	GI(Protien) :
PubChem	None	uM		DRD1	-	GI(Protien) :
PubChem	None	uM		DRD2	-	GI(Protien) :
PubChem	None	uM		GFER	-	GI(Protien) :
PubChem	Potency	uM	20.596	GMNN	-	GI(Protien) :
PubChem	None	uM		HTR2A		GI(Protien) :
PubChem	None	uM		HTR2C		GI(Protien) :
PubChem	None	uM		HTR6		GI(Protien) :
PubChem	None	uM		HTR7		GI(Protien) :
PubChem	Potency	uM	3.981	KCNH2		GI(Protien) :
PubChem	Potency	uM	3.981	KCNH2		GI(Protien) :
PubChem	None	uM		MAP4K2	-	GI(Protien) :
PubChem	AC50_uM	uM	12.410	MLLT3	-	GI(Protien) :
PubChem	None	uM		MLLT3	-	GI(Protien) :
PubChem	Potency	uM	28.184	MPHOSPH8	-	GI(Protien) :
PubChem	Potency	uM	7.362	MTOR	-	GI(Protien) :
PubChem	None	uM		PLA2G7	-	GI(Protien) :
PubChem	None	uM		PLA2G7	-	GI(Protien) :
PubChem	None	uM		PREPL	-	GI(Protien) :
PubChem	AC50_uM	uM	13.940	RAD52	-	GI(Protien) :
PubChem	None	uM		RAD52	-	GI(Protien) :
PubChem	None	uM		RAD52	-	GI(Protien) :
PubChem	Potency	uM	5.805	TDP1	-	GI(Protien) :
PubChem	Potency	uM	20.596	TDP1	-	GI(Protien) :
PubChem	Potency	uM	23.109	TDP1	-	GI(Protien) :
PubChem	Potency	uM	29.093	TDP1	-	GI(Protien) :
PubChem	Potency	uM	15.849	THPO	-	GI(Protien) :
PubChem	Potency	uM	10.000	TP53	-	GI(Protien) :
PubChem	Potency	uM	15.849	TP53	-	GI(Protien) :
PubChem	IC50	uM	13.424	UBE2N	-	GI(Protien) :
PubChem	IC50	uM	16.156	UBE2N	-	GI(Protien) :
PubChem	None	uM		UBE2N	-	GI(Protien) :
PubChem	None	uM		UBE2N	-	GI(Protien) :
ChEMBL	Potency	nM	31622.800	CBX1	-	Target : CHEMBL1741193
ChEMBL	AC50	nM	316.230	CYP1A2	-	Target : CHEMBL3356
ChEMBL	Potency	nM	199.500	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	31.600	CYP2D6	-	Target : CHEMBL289
ChEMBL	AC50	nM	31.620	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	794.300	DRD1	-	Target : CHEMBL2056
ChEMBL	Potency	nM	28183.800	MPHOSPH8	-	Target : CHEMBL1741210
ChEMBL	Potency	nM	7362.100	MTOR	-	Target : CHEMBL2842
ChEMBL	Potency	nM	15848.900	THPO	-	Target : CHEMBL1293256
ChEMBL	Potency	nM	15848.900	TP53	-	Target : CHEMBL4096
ChEMBL	Potency	nM	10000.000	TP53	-	Target : CHEMBL4096
ChEMBL	IC50	nM	16156.000	UBE2N	-	Target : CHEMBL6089
ChEMBL	IC50	nM	13424.000	UBE2N	-	Target : CHEMBL6089

Download gene sets

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