Tan Lab | DSigDB

Gene Set: D4 : CTD - Pentachlorophenol

Collection

D4 : CTD

Chemical Name

Pentachlorophenol ( From PubChem : PENTACHLOROPHENOL )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
266.337 g/mol	1	1	4.6592	True

Structure

InChI

InChI=1S/C6HCl5O/c7-1-2(8)4(10)6(12)5(11)3(1)9/h12H

InChIKey

IZUPBVBPLAPZRR-UHFFFAOYSA-N

Links

Gene (56 / 91)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(reaction)			ADH1C		D010416
CTD	increases(metabolic processing)			ADH1C		D010416
CTD	decreases(reaction)			ADH4		D010416
CTD	increases(metabolic processing)			ADH4		D010416
CTD	decreases(reaction)			ADH5		D010416
CTD	increases(metabolic processing)			ADH5		D010416
CTD	decreases(reaction)			ADH7		D010416
CTD	increases(metabolic processing)			ADH7		D010416
CTD	decreases(activity)			CASP3		D010416
CTD	increases(expression)			CCL3		D010416
CTD	decreases(expression)			CCR5		D010416
CTD	decreases(expression)			CSE1L		D010416
CTD	decreases(expression)			CYP11A1		D010416
CTD	decreases(expression)			CYP17A1		D010416
CTD	decreases(expression)			CYP19A1		D010416
CTD	increases(activity)			CYP1A1		D010416
CTD	increases(expression)			CYP1A1		D010416
CTD	increases(expression)			CYP2B6		D010416
CTD	increases(oxidation)			CYP2E1		D010416
CTD	increases(expression)			CYP3A4		D010416
CTD	increases(expression)			CYP3A7		D010416
CTD	increases(expression)			DNAJB4		D010416
CTD	increases(expression)			ERCC3		D010416
CTD	increases(expression)			ERCC4		D010416
CTD	affects(binding)			ESR1		D010416
CTD	decreases(activity)			ESR1		D010416
CTD	affects(binding)			ESR1		D010416
CTD	decreases(reaction)			ESR1		D010416
CTD	affects(expression)			FOS		D010416
CTD	decreases(expression)			HSD17B4		D010416
CTD	decreases(expression)			HSD3B1		D010416
CTD	increases(expression)			HSP90AA1		D010416
CTD	increases(expression)			IL21		D010416
CTD	increases(expression)			LTBR		D010416
CTD	decreases(reaction)			NAT1		D010416
CTD	increases(acetylation)			NAT1		D010416
CTD	decreases(activity)			PGR		D010416
CTD	increases(expression)			POR		D010416
CTD	increases(expression)			RAD23A		D010416
CTD	affects(binding)			SHBG		D010416
CTD	decreases(reaction)			SHBG		D010416
CTD	decreases(expression)			STAR		D010416
CTD	affects(cotreatment)			SULT1A1		D010416
CTD	decreases(reaction)			SULT1A1		D010416
CTD	increases(activity)			SULT1A1		D010416
CTD	affects(expression)			TP53		D010416
CTD	increases(expression)			TRADD		D010416
CTD	increases(expression)			UGT1A10		D010416
CTD	decreases(expression)			XCL2		D010416
CTD	increases(expression)			XRCC4		D010416
PubChem	Potency-Replicate_1	uM	3.368	AHR	-	GI(Protien) :
PubChem	AhR Potency (uM)	uM	12.903	AHR	-	GI(Protien) :
PubChem	AhR Potency (uM)	uM	30.567	AHR	-	GI(Protien) :
PubChem	Potency	uM	39.811	AHR	-	GI(Protien) :
PubChem	Potency	uM	44.668	AHR	-	GI(Protien) :
PubChem	None	uM		AHR	-	GI(Protien) :
PubChem	Potency	uM	17.783	ALDH1A1	-	GI(Protien) :
PubChem	None	uM		CRHBP	-	GI(Protien) :
PubChem	None	uM		CRHR2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	8.535	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	10.745	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	27.243	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	31.763	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	59.889	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	59.889	ESR1	-	GI(Protien) :
PubChem	Potency	uM	8.200	GMNN	-	GI(Protien) :
PubChem	Potency	uM	14.125	HPGD	-	GI(Protien) :
PubChem	None	uM		LYPLA2	-	GI(Protien) :
PubChem	None	uM		LYPLA2	-	GI(Protien) :
PubChem	None	uM		MCL1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	4.757	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	23.109	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	24.337	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	26.603	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	25.119	NR1H4	-	GI(Protien) :
PubChem	None	uM		NR2E3	-	GI(Protien) :
PubChem	None	uM		NR2E3	-	GI(Protien) :
PubChem	Potency	uM	26.680	PLK1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	3.398	PPARG	-	GI(Protien) :
PubChem	None	uM		PPARG	-	GI(Protien) :
PubChem	Potency	uM	20.596	TDP1	-	GI(Protien) :
PubChem	Potency	uM	23.109	TDP1	-	GI(Protien) :
PubChem	Potency	uM	31.623	TSHR	-	GI(Protien) :
PubChem	Potency	uM	79.433	USP1	-	GI(Protien) :
PubChem	Potency	uM	39.811	VDR	-	GI(Protien) :
PubChem	Potency	uM	89.125	VDR	-	GI(Protien) :
ChEMBL	Potency	nM	17782.800	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	14125.400	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	56234.100	KDM4A	-	Target : CHEMBL5896
ChEMBL	Potency	nM	23109.300	NFE2L2	-	Target : CHEMBL1075094
ChEMBL	Potency	nM	31622.800	TSHR	-	Target : CHEMBL1963

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