Tan Lab | DSigDB

Gene Set: D4 : CTD - Oxytetracycline

Collection

D4 : CTD

Chemical Name

Oxytetracycline ( From PubChem : OXYTETRACYCLINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
460.434 g/mol	7	11	-0.6999	False(2/4)

Structure

InChI

InChI=1S/C22H24N2O9/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29/h4-6,12-14,17,25-26,28,30,32-33H,1-3H3,(H2,23,31)/t12-,13-,14+,17+,21-,22+/m1/s1

InChIKey

OWFJMIVZYSDULZ-PXOLEDIWSA-N

Links

Gene (50 / 66)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(expression)			CCL2		D010118
CTD	decreases(expression)			CCL3		D010118
CTD	decreases(expression)			CCL4		D010118
CTD	decreases(expression)			CCL5		D010118
CTD	decreases(expression)			CXCL8		D010118
CTD	decreases(expression)			IL6R		D010118
CTD	decreases(reaction)			SLC22A6		D010118
CTD	increases(uptake)			SLC22A6		D010118
CTD	decreases(reaction)			SLC22A7		D010118
CTD	increases(uptake)			SLC22A7		D010118
CTD	decreases(expression)			VEGFA		D010118
PubChem	None	uM		ABL1	-	GI(Protien) :
PubChem	None	uM		ARNT	-	GI(Protien) :
PubChem	Potency	uM	2.818	BAZ2B	-	GI(Protien) :
PubChem	None	uM		BCL2L1	-	GI(Protien) :
PubChem	None	uM		CACNA1H	-	GI(Protien) :
PubChem	Potency	uM	3.981	CBX1	-	GI(Protien) :
PubChem	None	uM		CTDSP1	-	GI(Protien) :
PubChem	None	uM		DNMT1	-	GI(Protien) :
PubChem	Potency	uM	11.220	EHMT2	-	GI(Protien) :
PubChem	None	uM		EIF4G1	-	GI(Protien) :
PubChem	IC50	uM		EIF4H	-	GI(Protien) :
PubChem	Potency	uM	11.220	FEN1	-	GI(Protien) :
PubChem	Potency	uM	7.080	GLS	-	GI(Protien) :
PubChem	None	uM		GSTO1	-	GI(Protien) :
PubChem	Potency	uM	7.943	HIF1A	-	GI(Protien) :
PubChem	Potency	uM	28.184	KAT2A	-	GI(Protien) :
PubChem	Potency	uM	6.310	MAPT	-	GI(Protien) :
PubChem	Potency	uM	11.220	MAPT	-	GI(Protien) :
PubChem	None	uM		MCL1	-	GI(Protien) :
PubChem	None	uM		MCL1	-	GI(Protien) :
PubChem	None	uM		MCL1	-	GI(Protien) :
PubChem	IC50	uM		MPI	-	GI(Protien) :
PubChem	IC50	uM		PABPC1	-	GI(Protien) :
PubChem	None	uM		PAFAH1B2	-	GI(Protien) :
PubChem	None	uM		PAFAH1B3	-	GI(Protien) :
PubChem	None	uM		PAFAH2	-	GI(Protien) :
PubChem	None	uM		PLA2G7	-	GI(Protien) :
PubChem	Potency	uM	5.323	PLK1	-	GI(Protien) :
PubChem	Potency	uM	2.818	POLB	-	GI(Protien) :
PubChem	Potency	uM	3.981	POLH	-	GI(Protien) :
PubChem	Potency	uM	2.818	POLK	-	GI(Protien) :
PubChem	None	uM		PPP1CA	-	GI(Protien) :
PubChem	None	uM		PPP1CA	-	GI(Protien) :
PubChem	None	uM		RIN1	-	GI(Protien) :
PubChem	None	uM		SUMO1	-	GI(Protien) :
PubChem	None	uM		TACC3	-	GI(Protien) :
PubChem	Potency	uM	15.849	THRB	-	GI(Protien) :
PubChem	None	uM		TNNC1	-	GI(Protien) :
PubChem	None	uM		TNNI3	-	GI(Protien) :
PubChem	None	uM		TNNT2	-	GI(Protien) :
PubChem	None	uM		VCP	-	GI(Protien) :
PubChem	None	uM		VCP	-	GI(Protien) :
PubChem	Potency	uM	19.953	WRN	-	GI(Protien) :
ChEMBL	Potency	nM	2818.400	BAZ2B	-	Target : CHEMBL1741220
ChEMBL	Potency	nM	11220.200	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	7943.300	HIF1A	-	Target : CHEMBL4261
ChEMBL	Potency	nM	28183.800	KAT2A	-	Target : CHEMBL5501
ChEMBL	Potency	nM	1412.500	KDM4A	-	Target : CHEMBL5896
ChEMBL	Potency	nM	11220.200	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	6309.600	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	2818.400	POLB	-	Target : CHEMBL2392
ChEMBL	Potency	nM	11220.200	RECQL	-	Target : CHEMBL1293236
ChEMBL	Activity	-		SOD1	-	Target : CHEMBL2354
ChEMBL	Activity	-		SOD1	-	Target : CHEMBL2354
ChEMBL	Potency	nM	15848.900	THRB	-	Target : CHEMBL1947

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