Tan Lab | DSigDB

Gene Set: D4 : CTD - Noscapine

Collection

D4 : CTD

Chemical Name

Noscapine ( From PubChem : NOSCAPINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Approved	Not	Not	Approved	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
413.421 g/mol	0	8	2.8197	True

Structure

InChI

InChI=1S/C22H23NO7/c1-23-8-7-11-9-14-20(29-10-28-14)21(27-4)15(11)17(23)18-12-5-6-13(25-2)19(26-3)16(12)22(24)30-18/h5-6,9,17-18H,7-8,10H2,1-4H3/t17-,18+/m1/s1

InChIKey

AKNNEGZIBPJZJG-MSOLQXFVSA-N

Links

Gene (17 / 43)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(expression)			BAX		D009665
CTD	increases(reaction)			BAX		D009665
CTD	decreases(expression)			BCL2		D009665
CTD	increases(reaction)			BCL2		D009665
CTD	decreases(response to substance)			BIRC5		D009665
CTD	decreases(expression)			BIRC5		D009665
CTD	increases(reaction)			BIRC5		D009665
CTD	increases(expression)			BIRC5		D009665
CTD	affects(cotreatment)			CASP3		D009665
CTD	increases(cleavage)			CASP3		D009665
CTD	increases(expression)			CASP3		D009665
CTD	increases(reaction)			CASP3		D009665
CTD	increases(activity)			CASP3		D009665
CTD	increases(cleavage)			CASP9		D009665
CTD	increases(expression)			CASP9		D009665
CTD	increases(reaction)			CASP9		D009665
CTD	increases(expression)			CDKN1A		D009665
CTD	increases(reaction)			CDKN1A		D009665
CTD	decreases(reaction)			CYP1A1		D009665
CTD	increases(activity)			CYP1A1		D009665
CTD	decreases(activity)			HIF1A		D009665
CTD	decreases(expression)			HIF1A		D009665
CTD	increases(degradation)			HIF1A		D009665
CTD	increases(cleavage)			PARP1		D009665
CTD	decreases(reaction)			SLC22A2		D009665
CTD	increases(uptake)			SLC22A2		D009665
CTD	increases(expression)			TP53		D009665
CTD	increases(reaction)			TP53		D009665
CTD	increases(expression)			TP53		D009665
CTD	increases(phosphorylation)			TP53		D009665
CTD	decreases(secretion)			VEGFA		D009665
PubChem	Potency	uM	0.159	CYP2C19	-	GI(Protien) :
PubChem	None	uM		CYP2C19	-	GI(Protien) :
PubChem	Potency	uM	0.126	CYP2C9	-	GI(Protien) :
PubChem	None	uM		CYP2C9	-	GI(Protien) :
PubChem	Potency	uM	1.995	CYP3A4	-	GI(Protien) :
PubChem	None	uM		PTGER2	-	GI(Protien) :
PubChem	None	uM		SENP8	-	GI(Protien) :
ChEMBL	AC50	nM	158.490	CYP2C19	-	Target : CHEMBL3622
ChEMBL	Potency	nM	158.500	CYP2C19	-	Target : CHEMBL3622
ChEMBL	AC50	nM	125.890	CYP2C9	-	Target : CHEMBL3397
ChEMBL	Potency	nM	125.900	CYP2C9	-	Target : CHEMBL3397
ChEMBL	Potency	nM	1995.300	CYP3A4	-	Target : CHEMBL340

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