Tan Lab | DSigDB

Gene Set: D4 : CTD - mevastatin

Collection

D4 : CTD

Chemical Name

mevastatin ( From PubChem : MEVASTATIN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
390.513 g/mol	1	5	3.9495	True

Structure

InChI

InChI=1S/C23H34O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3/t14-,15-,17+,18+,19-,20-,22-/m0/s1

InChIKey

AJLFOPYRIVGYMJ-INTXDZFKSA-N

Links

Gene (16 / 28)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(expression)			BMP2		C012258
CTD	increases(activity)			CYP3A4		C012258
CTD	increases(expression)			CYP3A4		C012258
CTD	increases(expression)			CYP3A4		C012258
CTD	increases(expression)			CYP3A4		C012258
CTD	increases(reaction)			CYP3A4		C012258
CTD	increases(expression)			IL1B		C012258
CTD	increases(reaction)			IL1B		C012258
CTD	increases(activity)			NR1I2		C012258
CTD	increases(expression)			NR1I2		C012258
CTD	increases(expression)			NR1I2		C012258
CTD	increases(reaction)			NR1I2		C012258
CTD	increases(expression)			SELE		C012258
CTD	increases(reaction)			SELE		C012258
CTD	increases(expression)			TNF		C012258
CTD	increases(reaction)			TNF		C012258
PubChem	Ratio Potency (uM)	uM	11.986	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	15.089	AR	-	GI(Protien) :
PubChem	None	uM		CYP19A1	-	GI(Protien) :
PubChem	None	uM		DRD2	-	GI(Protien) :
PubChem	Potency	uM	4.109	IDH1	-	GI(Protien) :
PubChem	None	uM		JAK2	-	GI(Protien) :
PubChem	Potency	uM	15.849	NPSR1	-	GI(Protien) :
PubChem	None	uM		NR0B1	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :
PubChem	None	uM		SMARCA2	-	GI(Protien) :
PubChem	Potency	uM	14.581	TDP1	-	GI(Protien) :
ChEMBL	Potency	nM	15848.900	NPSR1	-	Target : CHEMBL5162

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