Tan Lab | DSigDB

Gene Set: D4 : CTD - Norepinephrine

Collection

D4 : CTD

Chemical Name

Norepinephrine ( From PubChem : NOREPINEPHRINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Approved	Not	Approved	Approved	Not	Approved	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
169.178 g/mol	4	4	0.7902	True

Structure

InChI

InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1

InChIKey

SFLSHLFXELFNJZ-QMMMGPOBSA-N

Links

Gene (52 / 173)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(binding)			ADRA1A		D009638
CTD	affects(binding)			ADRA1A		D009638
CTD	increases(activity)			ADRA1A		D009638
CTD	increases(abundance)			ADRA1A		D009638
CTD	decreases(reaction)			ADRA1A		D009638
CTD	affects(binding)			ADRA1B		D009638
CTD	increases(activity)			ADRA1B		D009638
CTD	increases(abundance)			ADRA1B		D009638
CTD	decreases(reaction)			ADRA1B		D009638
CTD	affects(binding)			ADRA1D		D009638
CTD	affects(binding)			ADRA1D		D009638
CTD	increases(activity)			ADRA1D		D009638
CTD	increases(abundance)			ADRA1D		D009638
CTD	decreases(reaction)			ADRA1D		D009638
CTD	affects(binding)			ADRA2A		D009638
CTD	decreases(reaction)			ADRA2A		D009638
CTD	increases(activity)			ADRA2A		D009638
CTD	affects(binding)			ADRA2A		D009638
CTD	increases(activity)			ADRA2A		D009638
CTD	affects(binding)			ADRA2A		D009638
CTD	increases(abundance)			ADRA2A		D009638
CTD	increases(activity)			ADRA2A		D009638
CTD	decreases(reaction)			ADRA2A		D009638
CTD	affects(binding)			ADRA2B		D009638
CTD	increases(activity)			ADRA2B		D009638
CTD	increases(abundance)			ADRA2B		D009638
CTD	decreases(reaction)			ADRA2B		D009638
CTD	affects(binding)			ADRA2C		D009638
CTD	increases(activity)			ADRA2C		D009638
CTD	increases(abundance)			ADRA2C		D009638
CTD	decreases(reaction)			ADRA2C		D009638
CTD	affects(binding)			ADRB1		D009638
CTD	increases(activity)			ADRB1		D009638
CTD	affects(binding)			ADRB1		D009638
CTD	increases(abundance)			ADRB1		D009638
CTD	increases(activity)			ADRB1		D009638
CTD	affects(binding)			ADRB1		D009638
CTD	decreases(reaction)			ADRB1		D009638
CTD	affects(binding)			ADRB1		D009638
CTD	decreases(reaction)			ADRB1		D009638
CTD	increases(activity)			ADRB1		D009638
CTD	increases(reaction)			ADRB1		D009638
CTD	affects(binding)			ADRB1		D009638
CTD	decreases(reaction)			ADRB1		D009638
CTD	affects(binding)			ADRB1		D009638
CTD	decreases(reaction)			ADRB1		D009638
CTD	affects(binding)			ADRB2		D009638
CTD	increases(activity)			ADRB2		D009638
CTD	affects(binding)			ADRB2		D009638
CTD	increases(abundance)			ADRB2		D009638
CTD	increases(activity)			ADRB2		D009638
CTD	decreases(reaction)			ADRB2		D009638
CTD	affects(binding)			ADRB2		D009638
CTD	decreases(reaction)			ADRB2		D009638
CTD	affects(binding)			ADRB3		D009638
CTD	increases(activity)			ADRB3		D009638
CTD	affects(binding)			ADRB3		D009638
CTD	increases(abundance)			ADRB3		D009638
CTD	increases(activity)			ADRB3		D009638
CTD	decreases(reaction)			ADRB3		D009638
CTD	affects(binding)			ADRB3		D009638
CTD	decreases(reaction)			ADRB3		D009638
CTD	decreases(reaction)			CASP3		D009638
CTD	increases(activity)			CASP3		D009638
CTD	increases(cleavage)			CASP3		D009638
CTD	decreases(reaction)			CASP7		D009638
CTD	increases(activity)			CASP7		D009638
CTD	increases(cleavage)			CASP7		D009638
CTD	increases(secretion)			CCL5		D009638
CTD	decreases(reaction)			CCL5		D009638
CTD	increases(methylation)			COMT		D009638
CTD	decreases(activity)			COMT		D009638
CTD	increases(abundance)			COMT		D009638
CTD	decreases(reaction)			CXCL8		D009638
CTD	increases(secretion)			CXCL8		D009638
CTD	affects(binding)			DRD2		D009638
CTD	decreases(transport)			DRD2		D009638
CTD	increases(activity)			DRD2		D009638
CTD	decreases(reaction)			DRD2		D009638
CTD	affects(cotreatment)			FN1		D009638
CTD	decreases(expression)			FN1		D009638
CTD	increases(expression)			FN1		D009638
CTD	increases(activity)			GNAS		D009638
CTD	increases(reaction)			GNAS		D009638
CTD	increases(expression)			IL6		D009638
CTD	increases(secretion)			IL6		D009638
CTD	decreases(reaction)			IL6		D009638
CTD	increases(metabolic processing)			MAOA		D009638
CTD	decreases(phosphorylation)			MAPK1		D009638
CTD	decreases(reaction)			MAPK1		D009638
CTD	decreases(phosphorylation)			MAPK3		D009638
CTD	decreases(reaction)			MAPK3		D009638
CTD	affects(binding)			NFKB1		D009638
CTD	affects(localization)			NFKB1		D009638
CTD	increases(activity)			NFKB1		D009638
CTD	affects(abundance)			NPPB		D009638
CTD	decreases(abundance)			NPPB		D009638
CTD	affects(response to substance)			NPY		D009638
CTD	affects(binding)			RELA		D009638
CTD	affects(localization)			RELA		D009638
CTD	increases(activity)			RELA		D009638
CTD	increases(expression)			S100A8		D009638
CTD	increases(expression)			S100A9		D009638
CTD	increases(expression)			S100B		D009638
CTD	affects(response to substance)			S100B		D009638
CTD	decreases(reaction)			SLC18A1		D009638
CTD	increases(uptake)			SLC18A1		D009638
CTD	affects(binding)			SLC18A2		D009638
CTD	decreases(activity)			SLC18A2		D009638
CTD	affects(binding)			SLC6A2		D009638
CTD	decreases(reaction)			SLC6A2		D009638
CTD	decreases(activity)			SLC6A2		D009638
CTD	decreases(expression)			SLC6A2		D009638
CTD	decreases(uptake)			SLC6A2		D009638
CTD	increases(activity)			SLC6A2		D009638
CTD	increases(reaction)			SLC6A2		D009638
CTD	increases(activity)			SLC6A3		D009638
CTD	increases(reaction)			SLC6A3		D009638
CTD	increases(uptake)			SLC6A3		D009638
CTD	increases(activity)			SLC6A4		D009638
CTD	increases(reaction)			SLC6A4		D009638
CTD	increases(sulfation)			SULT1A3		D009638
CTD	increases(activity)			TAAR1		D009638
CTD	increases(reaction)			TAAR1		D009638
CTD	increases(metabolic processing)			USF1		D009638
CTD	increases(reaction)			USF1		D009638
CTD	affects(reaction)			USF1		D009638
PubChem	Potency	uM	3.548	BLM	-	GI(Protien) :
PubChem	Potency	uM	0.291	DRD1	-	GI(Protien) :
PubChem	Potency	uM	1.995	DRD1	-	GI(Protien) :
PubChem	Potency	uM	2.239	DRD1	-	GI(Protien) :
PubChem	Potency	uM	3.981	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	9.466	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	10.000	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	2.119	FEN1	-	GI(Protien) :
PubChem	Potency	uM	2.119	FEN1	-	GI(Protien) :
PubChem	Potency	uM	33.808	FEN1	-	GI(Protien) :
PubChem	None	uM		GAPDH	-	GI(Protien) :
PubChem	Potency	uM	3.162	MAPT	-	GI(Protien) :
PubChem	Potency	uM	3.981	MAPT	-	GI(Protien) :
PubChem	Potency	uM	5.623	MAPT	-	GI(Protien) :
PubChem	Potency	uM	6.310	MAPT	-	GI(Protien) :
PubChem	None	uM		MAPT	-	GI(Protien) :
PubChem	None	uM		MAPT	-	GI(Protien) :
PubChem	Potency	uM	6.506	MBNL1	-	GI(Protien) :
PubChem	Potency	uM	1.901	POLH	-	GI(Protien) :
PubChem	Potency	uM	1.500	POLI	-	GI(Protien) :
PubChem	Potency	uM	0.708	POLK	-	GI(Protien) :
PubChem	Potency	uM	8.912	POLK	-	GI(Protien) :
PubChem	None	uM		PTGER2	-	GI(Protien) :
PubChem	Potency	uM	19.953	VDR	-	GI(Protien) :
ChEMBL	Activity	-		ADRA2A	-	Target : CHEMBL1867
ChEMBL	Activity	-		ADRA2A	-	Target : CHEMBL1867
ChEMBL	Selectivity	-		ADRB1	-	Target : CHEMBL213
ChEMBL	Selectivity	-		ADRB2	-	Target : CHEMBL210
ChEMBL	Potency	nM	794.300	APEX1	-	Target : CHEMBL5619
ChEMBL	Potency	nM	3548.100	BLM	-	Target : CHEMBL1293237
ChEMBL	Potency	nM	2238.700	DRD1	-	Target : CHEMBL2056
ChEMBL	Potency	nM	1995.300	DRD1	-	Target : CHEMBL2056
ChEMBL	Potency	nM	9466.200	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	10000.000	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	3981.100	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	2119.200	FEN1	-	Target : CHEMBL5027
ChEMBL	Potency	nM	7943.300	KDM4A	-	Target : CHEMBL5896
ChEMBL	Potency	nM	5623.400	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	6309.600	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	3981.100	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	3162.300	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	6506.400	MBNL1	-	Target : CHEMBL1293317
ChEMBL	Potency	nM	25118.900	RECQL	-	Target : CHEMBL1293236
ChEMBL	Potency	nM	2238.700	RECQL	-	Target : CHEMBL1293236
ChEMBL	Potency	nM	3548.100	RECQL	-	Target : CHEMBL1293236
ChEMBL	Potency	nM	2238.700	TDP1	-	Target : CHEMBL1075138

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