Tan Lab | DSigDB

Gene Set: D4 : CTD - Nitrendipine

Collection

D4 : CTD

Chemical Name

Nitrendipine ( From PubChem : NITRENDIPINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Approved	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
360.361 g/mol	1	5	3.4177	True

Structure

InChI

InChI=1S/C18H20N2O6/c1-5-26-18(22)15-11(3)19-10(2)14(17(21)25-4)16(15)12-7-6-8-13(9-12)20(23)24/h6-9,16,19H,5H2,1-4H3/t16-/m1/s1

InChIKey

Links

Gene (12 / 19)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(reaction)			ABCB11		D009568
CTD	increases(transport)			ABCB11		D009568
CTD	decreases(activity)			ABCB11		D009568
CTD	affects(response to substance)			AGTR1		D009568
CTD	affects(metabolic processing)			CYP3A4		D009568
CTD	decreases(reaction)			GAST		D009568
CTD	increases(secretion)			GAST		D009568
CTD	decreases(reaction)			GSTP1		D009568
CTD	increases(metabolic processing)			GSTP1		D009568
CTD	increases(activity)			REN		D009568
PubChem	Ratio Potency (uM)	uM	26.832	AR	-	GI(Protien) :
PubChem	IC50	uM	1.465	GPR55	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM		NR1H4	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :
PubChem	Potency	uM	1.458	PARK2	-	GI(Protien) :
PubChem	Potency	uM	11.886	TDP1	-	GI(Protien) :
PubChem	Potency	uM	14.963	TDP1	-	GI(Protien) :
PubChem	Potency	uM	19.234	TDP1	-	GI(Protien) :
PubChem	Potency	uM	24.214	TDP1	-	GI(Protien) :

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