Tan Lab | DSigDB

Gene Set: D4 : CTD - Niclosamide

Collection

D4 : CTD

Chemical Name

Niclosamide ( From PubChem : NICLOSAMIDE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Approved	Approved	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
327.12 g/mol	2	3	4.4557	True

Structure

InChI

InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)

InChIKey

RJMUSRYZPJIFPJ-UHFFFAOYSA-N

Links

Gene (134 / 263)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(expression)			ACACA		D009534
CTD	decreases(expression)			ACSL1		D009534
CTD	increases(cleavage)			AIFM1		D009534
CTD	decreases(reaction)			AKT1		D009534
CTD	increases(activity)			AKT1		D009534
CTD	decreases(expression)			ALDH1A1		D009534
CTD	increases(expression)			ALDOB		D009534
CTD	decreases(expression)			ALDOC		D009534
CTD	increases(expression)			ATP5A1		D009534
CTD	increases(expression)			ATP5D		D009534
CTD	decreases(expression)			ATP5F1		D009534
CTD	decreases(expression)			ATP5G3		D009534
CTD	decreases(expression)			ATP5J2		D009534
CTD	decreases(expression)			ATP5L		D009534
CTD	decreases(expression)			ATP5S		D009534
CTD	decreases(expression)			ATP6AP1		D009534
CTD	decreases(reaction)			AXIN2		D009534
CTD	increases(expression)			AXIN2		D009534
CTD	decreases(expression)			AXIN2		D009534
CTD	decreases(expression)			AXIN2		D009534
CTD	decreases(reaction)			BCL2		D009534
CTD	increases(expression)			BCL2		D009534
CTD	increases(response to substance)			BCL2		D009534
CTD	decreases(reaction)			BCL2		D009534
CTD	increases(expression)			BCL2		D009534
CTD	decreases(expression)			BCL2		D009534
CTD	decreases(reaction)			BCL2L1		D009534
CTD	increases(expression)			BCL2L1		D009534
CTD	decreases(reaction)			BCL2L2		D009534
CTD	increases(expression)			BCL2L2		D009534
CTD	increases(response to substance)			BCL2L2		D009534
CTD	decreases(expression)			BCL2L2		D009534
CTD	decreases(expression)			BIRC5		D009534
CTD	decreases(expression)			CASP3		D009534
CTD	decreases(reaction)			CCND1		D009534
CTD	increases(expression)			CCND1		D009534
CTD	decreases(expression)			CCND1		D009534
CTD	decreases(expression)			CCND1		D009534
CTD	increases(expression)			CCND2		D009534
CTD	decreases(expression)			CCND3		D009534
CTD	increases(expression)			CREBBP		D009534
CTD	increases(expression)			CSNK1E		D009534
CTD	increases(expression)			CTBP1		D009534
CTD	affects(binding)			CTNNB1		D009534
CTD	decreases(reaction)			CTNNB1		D009534
CTD	affects(localization)			CTNNB1		D009534
CTD	decreases(reaction)			CTNNB1		D009534
CTD	increases(stability)			CTNNB1		D009534
CTD	decreases(expression)			CTNNB1		D009534
CTD	increases(expression)			CTNNB1		D009534
CTD	affects(binding)			CTNNBIP1		D009534
CTD	decreases(reaction)			CTNNBIP1		D009534
CTD	increases(activity)			CYP1A1		D009534
CTD	decreases(activity)			CYP1A2		D009534
CTD	increases(metabolic processing)			CYP2C9		D009534
CTD	increases(reaction)			CYP2C9		D009534
CTD	increases(activity)			CYP2C9		D009534
CTD	decreases(activity)			CYP2D6		D009534
CTD	decreases(activity)			CYP3A4		D009534
CTD	decreases(expression)			DECR1		D009534
CTD	increases(expression)			DVL1		D009534
CTD	decreases(expression)			DVL2		D009534
CTD	increases(expression)			DVL3		D009534
CTD	decreases(expression)			ECHDC1		D009534
CTD	decreases(expression)			ECHS1		D009534
CTD	affects(binding)			EIF4E		D009534
CTD	increases(reaction)			EIF4E		D009534
CTD	decreases(reaction)			EIF4EBP1		D009534
CTD	increases(phosphorylation)			EIF4EBP1		D009534
CTD	affects(binding)			EIF4EBP1		D009534
CTD	increases(reaction)			EIF4EBP1		D009534
CTD	increases(expression)			ENO2		D009534
CTD	decreases(expression)			ENO3		D009534
CTD	increases(expression)			EP300		D009534
CTD	increases(expression)			FOSL1		D009534
CTD	affects(localization)			FZD1		D009534
CTD	decreases(expression)			FZD2		D009534
CTD	increases(expression)			FZD5		D009534
CTD	decreases(expression)			FZD9		D009534
CTD	increases(expression)			GOT2		D009534
CTD	decreases(expression)			GSK3B		D009534
CTD	decreases(expression)			HADH		D009534
CTD	decreases(expression)			HES1		D009534
CTD	increases(expression)			HEY2		D009534
CTD	decreases(reaction)			HEY2		D009534
CTD	increases(expression)			LDHA		D009534
CTD	decreases(expression)			LRP6		D009534
CTD	decreases(phosphorylation)			LRP6		D009534
CTD	decreases(expression)			MCL1		D009534
CTD	decreases(reaction)			MTOR		D009534
CTD	increases(phosphorylation)			MTOR		D009534
CTD	decreases(reaction)			MYC		D009534
CTD	increases(expression)			MYC		D009534
CTD	decreases(expression)			MYC		D009534
CTD	decreases(expression)			MYC		D009534
CTD	decreases(expression)			NDUFA10		D009534
CTD	increases(expression)			NDUFA4L2		D009534
CTD	decreases(expression)			NDUFA7		D009534
CTD	decreases(expression)			NDUFA8		D009534
CTD	decreases(expression)			NDUFB10		D009534
CTD	decreases(expression)			NDUFB6		D009534
CTD	increases(expression)			NDUFC1		D009534
CTD	decreases(expression)			NDUFS2		D009534
CTD	decreases(expression)			NDUFS3		D009534
CTD	decreases(expression)			NDUFS7		D009534
CTD	decreases(expression)			NDUFS8		D009534
CTD	increases(expression)			NDUFV3		D009534
CTD	decreases(reaction)			NFKBIA		D009534
CTD	increases(degradation)			NFKBIA		D009534
CTD	increases(phosphorylation)			NFKBIA		D009534
CTD	decreases(reaction)			NKD1		D009534
CTD	increases(expression)			NKD1		D009534
CTD	increases(expression)			NKD1		D009534
CTD	decreases(activity)			NOTCH1		D009534
CTD	increases(expression)			PC		D009534
CTD	decreases(expression)			PFKM		D009534
CTD	decreases(phosphorylation)			POU5F1		D009534
CTD	increases(expression)			PPARD		D009534
CTD	decreases(expression)			PPP2CB		D009534
CTD	increases(expression)			PPP2R1A		D009534
CTD	decreases(expression)			PPP2R2B		D009534
CTD	decreases(expression)			PPP2R2C		D009534
CTD	increases(expression)			PRKCQ		D009534
CTD	affects(localization)			RELA		D009534
CTD	decreases(reaction)			RELA		D009534
CTD	increases(activity)			RELA		D009534
CTD	decreases(expression)			S100A4		D009534
CTD	decreases(expression)			SLC2A1		D009534
CTD	decreases(expression)			SLC2A3		D009534
CTD	decreases(reaction)			STAT3		D009534
CTD	increases(phosphorylation)			STAT3		D009534
CTD	increases(response to substance)			STAT3		D009534
CTD	decreases(phosphorylation)			STAT3		D009534
CTD	affects(localization)			TNF		D009534
CTD	decreases(reaction)			TNF		D009534
CTD	increases(activity)			TNF		D009534
CTD	increases(degradation)			TNF		D009534
CTD	increases(expression)			TNF		D009534
CTD	increases(phosphorylation)			TNF		D009534
CTD	decreases(activity)			TNF		D009534
CTD	increases(expression)			TP53		D009534
CTD	increases(expression)			TPI1		D009534
CTD	decreases(expression)			WNT2B		D009534
CTD	decreases(expression)			WNT3		D009534
CTD	decreases(reaction)			WNT3A		D009534
CTD	increases(stability)			WNT3A		D009534
CTD	decreases(expression)			WNT3A		D009534
CTD	decreases(expression)			XIAP		D009534
PubChem	AhR Potency (uM)	uM	0.181	AHR	-	GI(Protien) :
PubChem	AhR Potency (uM)	uM	0.193	AHR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.211	AHR	-	GI(Protien) :
PubChem	Potency	uM	1.413	AHR	-	GI(Protien) :
PubChem	Potency	uM	3.981	ATXN2	-	GI(Protien) :
PubChem	None	uM		CFTR	-	GI(Protien) :
PubChem	None	uM		CRHBP	-	GI(Protien) :
PubChem	None	uM		CRHBP	-	GI(Protien) :
PubChem	None	uM		CRHR2	-	GI(Protien) :
PubChem	None	uM		CRHR2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	1.933	CYP19A1	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	0.631	CYP2C9	-	GI(Protien) :
PubChem	Potency	uM	2.512	CYP2C9	-	GI(Protien) :
PubChem	None	uM		CYP2C9	-	GI(Protien) :
PubChem	Potency	uM	31.623	CYP2D6	-	GI(Protien) :
PubChem	None	uM		CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	3.162	CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	15.849	CYP3A4	-	GI(Protien) :
PubChem	None	uM		CYP3A4	-	GI(Protien) :
PubChem	None	uM		DRD1	-	GI(Protien) :
PubChem	Potency	uM	7.943	EHMT2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.841	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	0.944	ESR1	-	GI(Protien) :
PubChem	None	uM		GCK	-	GI(Protien) :
PubChem	Potency	uM	0.316	GMNN	-	GI(Protien) :
PubChem	Potency	uM	3.162	GMNN	-	GI(Protien) :
PubChem	None	uM		HCRTR1	-	GI(Protien) :
PubChem	Potency	uM	2.512	HIF1A	-	GI(Protien) :
PubChem	Potency	uM	0.366	IDH1	-	GI(Protien) :
PubChem	None	uM		IL1B	-	GI(Protien) :
PubChem	Potency	uM	7.080	MAPT	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	None	uM		MITF	-	GI(Protien) :
PubChem	None	uM		MITF	-	GI(Protien) :
PubChem	Potency	uM	1.167	MTOR	-	GI(Protien) :
PubChem	Potency	uM	2.075	MTOR	-	GI(Protien) :
PubChem	Potency	uM	3.064	NFE2L2	-	GI(Protien) :
PubChem	None	uM		NLRP3	-	GI(Protien) :
PubChem	None	uM		NLRP3	-	GI(Protien) :
PubChem	None	uM		NLRP3	-	GI(Protien) :
PubChem	None	uM		NLRP3	-	GI(Protien) :
PubChem	Potency	uM	0.040	NPC1	-	GI(Protien) :
PubChem	Potency	uM	0.065	NPC1	-	GI(Protien) :
PubChem	None	uM		NR0B1	-	GI(Protien) :
PubChem	None	uM		OXTR	-	GI(Protien) :
PubChem	Potency	uM	3.162	PKM	-	GI(Protien) :
PubChem	Potency	uM	0.100	RAB9A	-	GI(Protien) :
PubChem	Potency	uM	2.512	RXRA	-	GI(Protien) :
PubChem	None	uM		SENP6	-	GI(Protien) :
PubChem	None	uM		SENP7	-	GI(Protien) :
PubChem	None	uM		SENP8	-	GI(Protien) :
PubChem	None	uM		SMN1	-	GI(Protien) :
PubChem	Potency	uM	0.126	SMN2	-	GI(Protien) :
PubChem	Potency	uM	25.119	SMN2	-	GI(Protien) :
PubChem	None	uM		STK33	-	GI(Protien) :
PubChem	Potency	uM	0.168	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.581	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.581	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.596	TDP1	-	GI(Protien) :
PubChem	Potency	uM	2.909	TDP1	-	GI(Protien) :
PubChem	Potency	uM	5.805	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.100	THPO	-	GI(Protien) :
PubChem	None	uM		TNFRSF10B	-	GI(Protien) :
PubChem	Potency	uM	0.501	TP53	-	GI(Protien) :
PubChem	Potency	uM	3.981	TP53	-	GI(Protien) :
PubChem	Potency	uM	0.338	TSHR	-	GI(Protien) :
PubChem	Potency	uM	0.501	TSHR	-	GI(Protien) :
PubChem	Potency	uM	1.000	TSHR	-	GI(Protien) :
PubChem	None	uM		TSHR		GI(Protien) :
PubChem	None	uM		TSHR		GI(Protien) :
ChEMBL	AC50	nM	3981.070	CYP1A2	-	Target : CHEMBL3356
ChEMBL	AC50	nM	1258.930	CYP1A2	-	Target : CHEMBL3356
ChEMBL	Potency	nM	631.000	CYP2C9	-	Target : CHEMBL3397
ChEMBL	AC50	nM	2511.890	CYP2C9	-	Target : CHEMBL3397
ChEMBL	Potency	nM	2511.900	CYP2C9	-	Target : CHEMBL3397
ChEMBL	AC50	nM	630.960	CYP2C9	-	Target : CHEMBL3397
ChEMBL	AC50	nM	31622.800	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	31622.800	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	3162.300	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	15848.900	CYP3A4	-	Target : CHEMBL340
ChEMBL	AC50	nM	3162.280	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	7943.300	EHMT2	-	Target : CHEMBL6032
ChEMBL	Activity	-		FZD1	-	Target : CHEMBL2346493
ChEMBL	Potency	nM	316.200	GMNN	-	Target : CHEMBL1293278
ChEMBL	Potency	nM	2511.900	HIF1A	-	Target : CHEMBL4261
ChEMBL	Potency	nM	7079.500	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	1166.800	MTOR	-	Target : CHEMBL2842
ChEMBL	Potency	nM	2074.900	MTOR	-	Target : CHEMBL2842
ChEMBL	Potency	nM	39.800	NPC1	-	Target : CHEMBL1293277
ChEMBL	Potency	nM	65.100	NPC1	-	Target : CHEMBL1293277
ChEMBL	Potency	nM	3162.300	PKM	-	Target : CHEMBL1075189
ChEMBL	Potency	nM	100.000	RAB9A	-	Target : CHEMBL1293294
ChEMBL	Potency	nM	125.900	SMN1; SMN2	-	Target : CHEMBL1293232
ChEMBL	Potency	nM	25118.900	SMN1; SMN2	-	Target : CHEMBL1293232
ChEMBL	Inhibition	-		STAT3	-	Target : CHEMBL4026
ChEMBL	Inhibition	-		STAT3	-	Target : CHEMBL4026
ChEMBL	Inhibition	-		STAT3	-	Target : CHEMBL4026
ChEMBL	Inhibition	-		STAT3	-	Target : CHEMBL4026
ChEMBL	Inhibition	-		STAT3	-	Target : CHEMBL4026
ChEMBL	Inhibition	-		STAT3	-	Target : CHEMBL4026
ChEMBL	Activity	-		STAT3	-	Target : CHEMBL4026
ChEMBL	Inhibition	-		STAT3	-	Target : CHEMBL4026
ChEMBL	Inhibition	-		STAT3	-	Target : CHEMBL4026
ChEMBL	Potency	nM	100.000	THPO	-	Target : CHEMBL1293256
ChEMBL	Potency	nM	501.200	TP53	-	Target : CHEMBL4096
ChEMBL	Potency	nM	3981.100	TP53	-	Target : CHEMBL4096
ChEMBL	Potency	nM	1000.000	TSHR	-	Target : CHEMBL1963
ChEMBL	Potency	nM	501.200	TSHR	-	Target : CHEMBL1963

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