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Gene Set: D4 : CTD - Nickel

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Collection	D4 : CTD
Chemical Name	Nickel ( From PubChem : NICKEL )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Not Not Not Not Not Not Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 58.6934 g/mol 0 0 0.0 True
Structure
InChI	InChI=1S/Ni
InChIKey	PXHVJJICTQNCMI-UHFFFAOYSA-N
Links
Gene (189 / 427) ⊖ Less	Source Type Unit Value Gene PMID Assay Other CTD decreases(reaction) ACO1 D009532 CTD increases(activity) ACO1 D009532 CTD increases(activity) ACO1 D009532 CTD affects(binding) ACTA2 D009532 CTD decreases(activity) ACTA2 D009532 CTD decreases(reaction) ACTA2 D009532 CTD increases(expression) ACTA2 D009532 CTD affects(expression) ADK D009532 CTD decreases(reaction) ADK D009532 CTD affects(binding) APP D009532 CTD affects(expression) ARFGEF1 D009532 CTD decreases(reaction) ARFGEF1 D009532 CTD affects(expression) ASCL2 D009532 CTD decreases(reaction) ASCL2 D009532 CTD affects(expression) ASIC5 D009532 CTD decreases(reaction) ASIC5 D009532 CTD increases(response to substance) ATP13A2 D009532 CTD affects(expression) ATP2A3 D009532 CTD decreases(reaction) ATP2A3 D009532 CTD increases(expression) AURKA D009532 CTD affects(cotreatment) BCL2 D009532 CTD decreases(expression) BCL2 D009532 CTD affects(expression) BCL2L11 D009532 CTD decreases(reaction) BCL2L11 D009532 CTD increases(expression) BIRC5 D009532 CTD affects(cotreatment) BIRC5 D009532 CTD decreases(expression) BIRC5 D009532 CTD affects(expression) BRIX1 D009532 CTD decreases(reaction) BRIX1 D009532 CTD increases(expression) BUB1B D009532 CTD decreases(reaction) CACNA1E D009532 CTD increases(transport) CACNA1E D009532 CTD decreases(reaction) CACNA1H D009532 CTD increases(transport) CACNA1H D009532 CTD increases(activity) CASP3 D009532 CTD increases(activity) CASP3 D009532 CTD increases(cleavage) CASP3 D009532 CTD affects(cotreatment) CASP3 D009532 CTD increases(activity) CASP3 D009532 CTD affects(reaction) CASP3 D009532 CTD increases(activity) CASP7 D009532 CTD increases(cleavage) CASP7 D009532 CTD increases(expression) CASP8 D009532 CTD affects(cotreatment) CASP9 D009532 CTD increases(activity) CASP9 D009532 CTD affects(binding) CASR D009532 CTD decreases(activity) CASR D009532 CTD decreases(reaction) CASR D009532 CTD increases(abundance) CASR D009532 CTD increases(expression) CASR D009532 CTD decreases(response to substance) CASR D009532 CTD affects(reaction) CASR D009532 CTD increases(activity) CASR D009532 CTD affects(reaction) CAT D009532 CTD increases(expression) CAT D009532 CTD affects(expression) CCL11 D009532 CTD decreases(reaction) CCL11 D009532 CTD increases(expression) CCNB2 D009532 CTD affects(expression) CCR2 D009532 CTD decreases(reaction) CCR2 D009532 CTD affects(expression) CCR5 D009532 CTD decreases(reaction) CCR5 D009532 CTD decreases(expression) CCR6 D009532 CTD affects(expression) CCR6 D009532 CTD decreases(reaction) CCR6 D009532 CTD affects(expression) CD44 D009532 CTD decreases(reaction) CD44 D009532 CTD affects(expression) CD46 D009532 CTD decreases(reaction) CD46 D009532 CTD increases(expression) CD86 D009532 CTD affects(binding) CDC20 D009532 CTD increases(expression) CDC25B D009532 CTD increases(expression) CDKN1A D009532 CTD affects(reaction) CDKN1A D009532 CTD affects(expression) CDX4 D009532 CTD decreases(reaction) CDX4 D009532 CTD affects(expression) CHL1 D009532 CTD decreases(reaction) CHL1 D009532 CTD decreases(expression) CHPT1 D009532 CTD affects(expression) CHRM4 D009532 CTD decreases(reaction) CHRM4 D009532 CTD increases(expression) CKS2 D009532 CTD affects(expression) CLDN3 D009532 CTD decreases(reaction) CLDN3 D009532 CTD affects(expression) CLDN5 D009532 CTD decreases(reaction) CLDN5 D009532 CTD decreases(expression) CLIP1 D009532 CTD affects(expression) CLU D009532 CTD decreases(reaction) CLU D009532 CTD affects(binding) COL1A1 D009532 CTD decreases(activity) COL1A1 D009532 CTD decreases(reaction) COL1A1 D009532 CTD increases(expression) COL1A1 D009532 CTD affects(expression) CREM D009532 CTD decreases(reaction) CREM D009532 CTD affects(expression) CRKL D009532 CTD decreases(reaction) CRKL D009532 CTD affects(expression) CX3CL1 D009532 CTD decreases(reaction) CX3CL1 D009532 CTD increases(expression) CXCL8 D009532 CTD affects(expression) CYP1B1 D009532 CTD decreases(reaction) CYP1B1 D009532 CTD affects(expression) CYP24A1 D009532 CTD decreases(reaction) CYP24A1 D009532 CTD affects(expression) DCC D009532 CTD decreases(reaction) DCC D009532 CTD affects(expression) DPPA2 D009532 CTD decreases(reaction) DPPA2 D009532 CTD decreases(activity) EHMT2 D009532 CTD decreases(expression) EHMT2 D009532 CTD affects(expression) ELL2 D009532 CTD decreases(reaction) ELL2 D009532 CTD increases(expression) EMB D009532 CTD affects(expression) EMB D009532 CTD decreases(reaction) EMB D009532 CTD affects(expression) EPHA7 D009532 CTD decreases(reaction) EPHA7 D009532 CTD increases(expression) ETS2 D009532 CTD affects(expression) FAHD1 D009532 CTD decreases(reaction) FAHD1 D009532 CTD increases(expression) FOS D009532 CTD affects(expression) FOXB1 D009532 CTD decreases(reaction) FOXB1 D009532 CTD affects(expression) FXYD3 D009532 CTD decreases(reaction) FXYD3 D009532 CTD affects(expression) FZD4 D009532 CTD decreases(reaction) FZD4 D009532 CTD affects(expression) GEM D009532 CTD decreases(reaction) GEM D009532 CTD affects(expression) GNRHR D009532 CTD decreases(reaction) GNRHR D009532 CTD affects(expression) GRIA2 D009532 CTD decreases(reaction) GRIA2 D009532 CTD increases(expression) GSTA1 D009532 CTD affects(expression) GSTM3 D009532 CTD decreases(reaction) GSTM3 D009532 CTD affects(binding) HDAC8 D009532 CTD decreases(reaction) HIF1A D009532 CTD increases(expression) HIF1A D009532 CTD increases(stability) HIF1A D009532 CTD decreases(reaction) HIF1A D009532 CTD increases(stability) HIF1A D009532 CTD decreases(reaction) HIF1A D009532 CTD increases(expression) HIF1A D009532 CTD affects(reaction) HIF1A D009532 CTD increases(expression) HIF1A D009532 CTD increases(expression) HIF1A D009532 CTD increases(reaction) HIF1A D009532 CTD increases(expression) HIF1A D009532 CTD increases(reaction) HIF1A D009532 CTD affects(localization) HIF1A D009532 CTD affects(cotreatment) HIF1A D009532 CTD decreases(expression) HIF1A D009532 CTD decreases(degradation) HIF1A D009532 CTD increases(activity) HIF1A D009532 CTD increases(stability) HIF1A D009532 CTD affects(reaction) HIF1A D009532 CTD decreases(reaction) HIF1A D009532 CTD decreases(ubiquitination) HIST2H2AC D009532 CTD increases(ubiquitination) HIST2H2AC D009532 CTD decreases(methylation) HIST3H2BB D009532 CTD decreases(ubiquitination) HIST3H2BB D009532 CTD increases(methylation) HIST3H2BB D009532 CTD increases(ubiquitination) HIST3H2BB D009532 CTD affects(cotreatment) HIST3H3 D009532 CTD increases(acetylation) HIST3H3 D009532 CTD increases(methylation) HIST3H3 D009532 CTD increases(methylation) HIST3H3 D009532 CTD affects(response to substance) HLA-DRB4 D009532 CTD increases(expression) HMOX1 D009532 CTD increases(reaction) HMOX1 D009532 CTD increases(expression) HMOX1 D009532 CTD affects(expression) HMX1 D009532 CTD decreases(reaction) HMX1 D009532 CTD affects(expression) HNF1B D009532 CTD decreases(reaction) HNF1B D009532 CTD affects(expression) HOXD1 D009532 CTD decreases(reaction) HOXD1 D009532 CTD affects(expression) HSPA1L D009532 CTD decreases(reaction) HSPA1L D009532 CTD affects(expression) IBSP D009532 CTD decreases(reaction) IBSP D009532 CTD affects(binding) ICAM1 D009532 CTD decreases(activity) ICAM1 D009532 CTD decreases(reaction) ICAM1 D009532 CTD increases(expression) ICAM1 D009532 CTD increases(expression) ICAM1 D009532 CTD increases(expression) ICAM1 D009532 CTD affects(expression) IFNG D009532 CTD decreases(reaction) IFNG D009532 CTD affects(expression) IFT27 D009532 CTD decreases(reaction) IFT27 D009532 CTD decreases(response to substance) IGF1 D009532 CTD decreases(response to substance) IGF2 D009532 CTD affects(binding) IL1B D009532 CTD decreases(activity) IL1B D009532 CTD decreases(reaction) IL1B D009532 CTD increases(expression) IL1B D009532 CTD affects(expression) IL2RA D009532 CTD decreases(reaction) IL2RA D009532 CTD affects(expression) IL36RN D009532 CTD decreases(reaction) IL36RN D009532 CTD increases(secretion) IL5 D009532 CTD affects(expression) INHBB D009532 CTD decreases(reaction) INHBB D009532 CTD affects(expression) ITGAL D009532 CTD decreases(reaction) ITGAL D009532 CTD affects(expression) JAG2 D009532 CTD decreases(reaction) JAG2 D009532 CTD affects(expression) JAK2 D009532 CTD decreases(reaction) JAK2 D009532 CTD affects(expression) KCNMA1 D009532 CTD decreases(reaction) KCNMA1 D009532 CTD affects(reaction) KDM3A D009532 CTD increases(expression) KDM3A D009532 CTD increases(phosphorylation) KDM3A D009532 CTD decreases(reaction) KDM3A D009532 CTD increases(expression) KEAP1 D009532 CTD increases(expression) KIF2C D009532 CTD affects(expression) KLRG1 D009532 CTD decreases(reaction) KLRG1 D009532 CTD affects(expression) KRT10 D009532 CTD decreases(reaction) KRT10 D009532 CTD affects(expression) LIPA D009532 CTD decreases(reaction) LIPA D009532 CTD affects(expression) LRRC6 D009532 CTD decreases(reaction) LRRC6 D009532 CTD affects(expression) MAFB D009532 CTD decreases(reaction) MAFB D009532 CTD affects(expression) MAP4K2 D009532 CTD decreases(reaction) MAP4K2 D009532 CTD decreases(reaction) MAPK1 D009532 CTD increases(phosphorylation) MAPK1 D009532 CTD affects(reaction) MAPK1 D009532 CTD increases(phosphorylation) MAPK1 D009532 CTD decreases(reaction) MAPK1 D009532 CTD increases(phosphorylation) MAPK1 D009532 CTD decreases(reaction) MAPK3 D009532 CTD increases(phosphorylation) MAPK3 D009532 CTD affects(reaction) MAPK3 D009532 CTD increases(phosphorylation) MAPK3 D009532 CTD decreases(reaction) MAPK3 D009532 CTD increases(phosphorylation) MAPK3 D009532 CTD affects(expression) MARK1 D009532 CTD decreases(reaction) MARK1 D009532 CTD affects(expression) MCM7 D009532 CTD decreases(reaction) MCM7 D009532 CTD increases(expression) MDM2 D009532 CTD affects(reaction) MDM2 D009532 CTD decreases(expression) MDM4 D009532 CTD affects(expression) MEF2A D009532 CTD decreases(reaction) MEF2A D009532 CTD affects(expression) MGP D009532 CTD decreases(reaction) MGP D009532 CTD affects(expression) MMP12 D009532 CTD decreases(reaction) MMP12 D009532 CTD increases(activity) MMP2 D009532 CTD increases(expression) MMP2 D009532 CTD affects(reaction) MMP2 D009532 CTD decreases(reaction) MMP2 D009532 CTD increases(expression) MMP2 D009532 CTD increases(activity) MMP9 D009532 CTD increases(expression) MMP9 D009532 CTD affects(reaction) MMP9 D009532 CTD decreases(reaction) MMP9 D009532 CTD affects(expression) MS4A2 D009532 CTD decreases(reaction) MS4A2 D009532 CTD decreases(reaction) MT2A D009532 CTD increases(expression) MT2A D009532 CTD increases(expression) MT2A D009532 CTD affects(localization) MTF1 D009532 CTD increases(activity) MTF1 D009532 CTD affects(expression) MTTP D009532 CTD decreases(reaction) MTTP D009532 CTD affects(expression) MX1 D009532 CTD decreases(reaction) MX1 D009532 CTD affects(expression) MYH3 D009532 CTD decreases(reaction) MYH3 D009532 CTD affects(expression) MYT1L D009532 CTD decreases(reaction) MYT1L D009532 CTD affects(expression) NACA D009532 CTD decreases(reaction) NACA D009532 CTD affects(expression) NCOA4 D009532 CTD decreases(reaction) NCOA4 D009532 CTD affects(expression) NCR1 D009532 CTD decreases(reaction) NCR1 D009532 CTD increases(expression) NDRG1 D009532 CTD increases(reaction) NDRG1 D009532 CTD increases(expression) NDRG1 D009532 CTD affects(expression) NDUFB6 D009532 CTD decreases(reaction) NDUFB6 D009532 CTD affects(expression) NDUFC2 D009532 CTD decreases(reaction) NDUFC2 D009532 CTD increases(expression) NEK2 D009532 CTD decreases(expression) NEK4 D009532 CTD affects(reaction) NFATC4 D009532 CTD increases(expression) NFATC4 D009532 CTD affects(expression) NOMO1 D009532 CTD decreases(reaction) NOMO1 D009532 CTD affects(binding) NOS3 D009532 CTD decreases(expression) NOS3 D009532 CTD decreases(reaction) NOS3 D009532 CTD increases(reaction) NOS3 D009532 CTD affects(expression) NPR1 D009532 CTD decreases(reaction) NPR1 D009532 CTD increases(expression) NQO1 D009532 CTD increases(expression) NUSAP1 D009532 CTD increases(expression) PAK3 D009532 CTD increases(expression) PAPD7 D009532 CTD increases(expression) PBK D009532 CTD increases(expression) PLK1 D009532 CTD affects(expression) POLK D009532 CTD decreases(reaction) POLK D009532 CTD increases(expression) PRKCZ D009532 CTD affects(expression) PRKCZ D009532 CTD decreases(reaction) PRKCZ D009532 CTD affects(binding) PRNP D009532 CTD affects(expression) PRPF39 D009532 CTD decreases(reaction) PRPF39 D009532 CTD affects(expression) PRSS2 D009532 CTD decreases(reaction) PRSS2 D009532 CTD affects(reaction) PTGS2 D009532 CTD increases(expression) PTGS2 D009532 CTD affects(expression) PTH D009532 CTD decreases(reaction) PTH D009532 CTD affects(expression) PTPN22 D009532 CTD decreases(reaction) PTPN22 D009532 CTD increases(expression) PTTG1 D009532 CTD affects(expression) PVT1 D009532 CTD decreases(reaction) PVT1 D009532 CTD affects(expression) RNMTL1 D009532 CTD decreases(reaction) RNMTL1 D009532 CTD decreases(expression) RPTN D009532 CTD affects(expression) RPTN D009532 CTD decreases(reaction) RPTN D009532 CTD affects(expression) RRH D009532 CTD decreases(reaction) RRH D009532 CTD affects(expression) SCN1A D009532 CTD decreases(reaction) SCN1A D009532 CTD affects(binding) SCO1 D009532 CTD affects(folding) SCO1 D009532 CTD affects(expression) SEC24B D009532 CTD decreases(reaction) SEC24B D009532 CTD affects(expression) SELP D009532 CTD decreases(reaction) SELP D009532 CTD affects(expression) SEPT5 D009532 CTD decreases(reaction) SEPT5 D009532 CTD increases(expression) SERPINE1 D009532 CTD increases(reaction) SERPINE1 D009532 CTD decreases(reaction) SERPINE1 D009532 CTD affects(expression) SFPQ D009532 CTD decreases(reaction) SFPQ D009532 CTD affects(expression) SLC2A5 D009532 CTD decreases(reaction) SLC2A5 D009532 CTD affects(expression) SLC35A4 D009532 CTD decreases(reaction) SLC35A4 D009532 CTD affects(expression) SLC38A2 D009532 CTD decreases(reaction) SLC38A2 D009532 CTD decreases(reaction) SLC8A1 D009532 CTD increases(uptake) SLC8A1 D009532 CTD increases(reaction) SLC8A1 D009532 CTD increases(expression) SMC4 D009532 CTD affects(expression) SNCG D009532 CTD decreases(reaction) SNCG D009532 CTD increases(activity) SP1 D009532 CTD increases(expression) SPAG5 D009532 CTD affects(expression) SPINT2 D009532 CTD decreases(reaction) SPINT2 D009532 CTD decreases(expression) SPRY2 D009532 CTD affects(reaction) SPRY2 D009532 CTD increases(phosphorylation) SPRY2 D009532 CTD decreases(reaction) SPRY2 D009532 CTD decreases(reaction) SRC D009532 CTD increases(phosphorylation) SRC D009532 CTD affects(reaction) STAT1 D009532 CTD decreases(reaction) STAT1 D009532 CTD increases(expression) STAT1 D009532 CTD increases(stability) STAT1 D009532 CTD affects(expression) TFAP2B D009532 CTD decreases(reaction) TFAP2B D009532 CTD affects(expression) THEG D009532 CTD decreases(reaction) THEG D009532 CTD increases(expression) TIMP1 D009532 CTD affects(binding) TNF D009532 CTD decreases(activity) TNF D009532 CTD decreases(reaction) TNF D009532 CTD increases(expression) TNF D009532 CTD increases(expression) TNF D009532 CTD increases(secretion) TNF D009532 CTD decreases(reaction) TNF D009532 CTD increases(secretion) TNF D009532 CTD increases(expression) TP53 D009532 CTD increases(phosphorylation) TP53 D009532 CTD affects(cotreatment) TP53 D009532 CTD increases(expression) TP53 D009532 CTD affects(reaction) TP53 D009532 CTD increases(activity) TP53 D009532 CTD increases(cleavage) TP53 D009532 CTD increases(expression) TPX2 D009532 CTD affects(expression) TRPC6 D009532 CTD decreases(reaction) TRPC6 D009532 CTD affects(expression) TSC1 D009532 CTD decreases(reaction) TSC1 D009532 CTD affects(expression) TYRO3 D009532 CTD decreases(reaction) TYRO3 D009532 CTD decreases(expression) UBE2A D009532 CTD increases(expression) UBE2E1 D009532 CTD affects(expression) UNC93B1 D009532 CTD decreases(reaction) UNC93B1 D009532 CTD affects(expression) VAMP7 D009532 CTD decreases(reaction) VAMP7 D009532 CTD affects(expression) VDR D009532 CTD decreases(reaction) VDR D009532 CTD decreases(reaction) VEGFA D009532 CTD increases(expression) VEGFA D009532 CTD increases(secretion) VEGFA D009532 CTD decreases(reaction) VEGFA D009532 CTD increases(expression) VEGFA D009532 CTD affects(reaction) VEGFA D009532 CTD affects(expression) VPS35 D009532 CTD decreases(reaction) VPS35 D009532 CTD affects(expression) WBP1 D009532 CTD decreases(reaction) WBP1 D009532 CTD affects(expression) XIST D009532 CTD decreases(reaction) XIST D009532 CTD affects(expression) ZIC3 D009532 CTD decreases(reaction) ZIC3 D009532
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